Granuloma Faciale With Lesions on the Face and Hand

Okun, Milton R.; Bauman, Louis; Minor, Dwane B.

doi:10.1001/archderm.1965.01600130084017

Cited by 23 publications

(5 citation statements)

References 4 publications

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“…To our knowledge there have been 32 previously reported cases of extrafacial GF (Table 1) [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25]. In these cases the average age of the patients was 51 years, with 68.5% being male.…”

Section: Discussionmentioning

confidence: 99%

Extrafacial Granuloma Faciale: A Case Report and Brief Review

2017

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Granuloma faciale (GF) is a rare, inflammatory, cutaneous disorder of unknown aetiology. It presents clinically as one or several well-circumscribed violaceous papules, plaques, and nodules almost exclusively confined to the facial region. Rarely, extrafacial lesions can occur, most often on sun-exposed sites. We report a case of extrafacial GF in a 63-year-old male with indolent lymphoma, who presented with plaques involving the right preauricular region and left posterior axilla. The clinical and histopathological findings were consistent with GF. Our case highlights the importance of performing skin biopsies in patients with persistent erythematous plaques and nodules, particularly to exclude important malignant and granulomatous differential diagnoses.

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Section: Discussionmentioning

confidence: 99%

Extrafacial Granuloma Faciale: A Case Report and Brief Review

2017

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“…There are several reports of extrafacial involvement in GF 5–10 . Overall, the nose is the most commonly affected area, followed by the malar prominences, the forehead, and the preauricular and postauricular areas, chin, forearms, trunk and least often the lower extremities 11 .…”

Section: Discussionmentioning

confidence: 99%

Disseminated granuloma faciale

Zargari

2004

Int J Dermatology

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A 40-year-old man presented in January 2001 with multiple purple plaques and nodules, which had been present on the back for approximately 3 years. The lesions had gradually extended over the face, trunk and proximal extremities. He had no symptoms except occasional mild pruritus. The patient was in good health and was on no medications. Physical examination revealed multiple violaceous to brown, indurated, 5-50-mm, round to oval plaques on the face, arms, shoulders, and back (Fig. 1), as well as a solitary lesion on the right thigh. Surface telangiectases were noted, especially on the shoulder lesions. There was no scaling or ulceration. Routine laboratory tests were unremarkable. In April 1999, another medical center performed a biopsy of what they thought was sarcoidosis. The results were reported as "possible angiolymphoid hyperplasia with eosinophilia." With the possibility of granuoma faciale (GF) in mind, another skin biopsy was obtained from a facial lesion. This revealed a diffuse, relatively dense infiltrate of neutrophils, eosinophils and mononuclear inflammatory cells in dermis with an obvious Grenz zone (Fig. 2). Pilar units were intact, and endothelial cell swelling was present (Fig. 3). Retrospective evaluation of the initial biopsy, taken from the back, revealed the same changes, and helped confirm the diagnosis of GF. The patient was treated with liquid nitrogen for 20 s followed immediately by intralesional triamcinolone acetonide (5 mg/ml). This treatment was repeated every 4 weeks for three courses, resulting in partial resolution of the lesions.

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“…Eventualmente toda a derme pode ser invadida pelo infiltrado, que pode atingir até o tecido subcutâneo [2]. Separando o infiltrado da epiderme, existe uma faixa de tecido conectivo normal, colágeno, muito característica, chamada zona Grenz [1,3,9,18]. Dois estágios podem ser diferenciados na evolução do infiltrado: um inicial, leucocitário, e outro tardio, fibrótico.…”

Section: Histopatologiaunclassified

“…Freqüentemente ocorre leucocitoclasia e acúmulo de material acidófilo ao redor dos capilares. O padrão histológico é, portan to, de uma vasculite leucocitoclássica, com necrose das paredes vasculares e hemorragia [8,9]. Os histiócitos podem mostrar atividade fagocítica, com presença Incidência ' O granuloma facial incide principalmente em indiví duos brancos, mas pode ocorrer em outras raças [5,14,15,18].…”

Section: Histopatologiaunclassified