Granuloma faciale: A clinicopathologic study of 66 patients

Recalcitrant granuloma faciale with 14-year follow-up

“…Treatment is challenging, as GF is usually resistant to various modalities [1]. Diagnosis of GF is confirmed by its characteristic clinical appearance and histologic evaluation of the lesion.…”

“…Evidence of vasculitis is often present. Direct immunofluorescence may demonstrate the presence of IgG, IgM, IgA and C3 in the basement membrane zone and around the walls of blood vessels [1,5]. This disease is often characterized by chronicity, recurrence, and the onset of new lesions.…”

“…Granuloma faciale (GF) is an uncommon inflammatory dermatosis that is characterized by one or several asymptomatic brown red nodules or plaques on the face and polymorphous dense dermal infiltrates with vascular damage [1,2]. GF is known to be extremely resistant to treatment, although some cases may resolve spontaneously.…”

Dermoscopy of granuloma faciale

“…Dilated follicular openings have also been described as a common feature that may be useful in differentiating GF from BCC, sarcoidosis and cutaneous lymphoma. 3 The brown dots/globules, detected under dermoscopy, could possibly correspond to hemosiderin deposition which is known to be part of the pathophysiological process of GF. 3 …”

“…3 The brown dots/globules, detected under dermoscopy, could possibly correspond to hemosiderin deposition which is known to be part of the pathophysiological process of GF. 3 …”