Granuloma annulare on the palms

Muse, Mikel E.; Prohaska, Joseph R.; Shah, Muneeb; White, W. E.; Appel, James Z.

doi:10.5070/d3274053163

Cited by 2 publications

(1 citation statement)

References 7 publications

(12 reference statements)

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“…Additionally, granulomatous inflammation is a known reaction to occur with SCC, and the hallmark histopathologic features of GA may have previously gone unnoticed [11]. With the assistance of clinical correlation, GA can be distinguished from granulomatous inflammation on histopathology by containing focal areas of necrobiosis surrounded by palisades of histiocytes in the dermis with characteristic mucin deposition [12]. Additionally, GA can be distinguished from actinic granuloma by lack of significant elastophagocytosis.…”

Section: Discussionmentioning

confidence: 99%

A Unique Case of Squamous Cell Carcinoma Presenting Within a Lesion of Granuloma Annulare

Zabel¹,

Evans²,

Sutton³

et al. 2022

Cureus

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Granuloma annulare (GA) is a common benign granulomatous inflammatory disorder of the dermis or subcutis with classic morphologic and histologic presentation. Common clinical subtypes of granuloma annulare include localized, generalized, subcutaneous, perforating, and patch types. A biopsy is critical in cases of granuloma annulare with atypical features. We present a case of a 58-year-old male who presented with an annular scaly erythematous plaque on the right dorsal hand. Shave biopsy demonstrated irregular nests of mildly atypical squamous epithelium present within the superficial dermis, with abundant histiocytes and multinucleated giant cells arranged in palisades peripherally. These findings were consistent with invasive well-differentiated squamous cell carcinoma (SCC) with surrounding granuloma annulare. This case highlights a unique presentation in which clinicopathologic correlation is critical prior to arriving at a correct diagnosis.

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Section: Discussionmentioning

confidence: 99%

A Unique Case of Squamous Cell Carcinoma Presenting Within a Lesion of Granuloma Annulare

Zabel¹,

Evans²,

Sutton³

et al. 2022

Cureus

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Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

Joshi

Duvic

2021

Am J Clin Dermatol

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Granuloma annulare (GA) is an inflammatory granulomatous skin disease that can be localized (localized GA) or disseminated (generalized GA), with patch, perforating, and subcutaneous subtypes being less common variants of this benign condition. Recently, new research has emerged that further elucidates GA epidemiology and etiopathogenesis; importantly, new therapeutic options for GA have also been described, although there remains a paucity of randomized controlled studies. In this review, we summarize recent updates on GA epidemiology and etiopathogenesis and offer an updated review of the therapeutic options for GA currently reported in the literature. We hope that the current review galvanizes randomized controlled studies that will in turn help lead to the recommendation of evidence-based treatments for GA.

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Granuloma annulare on the palms

Cited by 2 publications

References 7 publications

A Unique Case of Squamous Cell Carcinoma Presenting Within a Lesion of Granuloma Annulare

A Unique Case of Squamous Cell Carcinoma Presenting Within a Lesion of Granuloma Annulare

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

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