Granulocytopenia Due to Clindamycin

Fleming, Gini F.; Crowe, Gillian

doi:10.5694/j.1326-5377.1976.tb140446.x

Cited by 4 publications

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“…Our literature review produced only three reports of clindamycin-induced neutropenia. [3][4][5] In one report, a 44-year-old man received clindamycin for 6 days to treat an infected finger; 13 days later he was neutropenic, with an absolute neutrophil count of 50 cells/mm 3 . 3 His neutropenia resolved over the next 8 days.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] In one report, a 44-year-old man received clindamycin for 6 days to treat an infected finger; 13 days later he was neutropenic, with an absolute neutrophil count of 50 cells/mm 3 . 3 His neutropenia resolved over the next 8 days. In the second report, one patient in a series of 30 patients given clindamycin for treatment of anaerobic pneumonia experienced transient neutropenia after 2 weeks of therapy.…”

Section: Discussionmentioning

confidence: 99%

“…1, 2 A review of the literature surprisingly produced only three published reports of this reaction; only one provided the duration of the event. [3][4][5]…”

Section: (Pharmacotherapy 2003;23(1):101-103)mentioning

confidence: 99%

“…No significant changes were noted in his hemoglobin level, and his platelet count, although decreased, never fell below 100 x 10 3 /mm 3 . However, his absolute neutrophil count fell to 945 cells/mm 3 (Table 1). No changes had been made in his drug regimen for the previous 5 weeks, and he was not taking any herbal or nutritional supplements.…”

Section: Case Reportmentioning

confidence: 99%

“…single dose of clindamycin before having a tooth extracted. He was neutropenic 6 days later, with an absolute neutrophil count of 945 cells/mm 3 . His neutrophil count returned to normal within 2 weeks.…”

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confidence: 99%

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Neutropenia After Single‐Dose Clindamycin for Dental Prophylaxis

2003

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A 68-year-old man with stable chronic myelogenous leukemia received a single dose of clindamycin before having a tooth extracted. He was neutropenic 6 days later, with an absolute neutrophil count of 945 cells/mm3. His neutrophil count returned to normal within 2 weeks. Clindamycin has been implicated in drug-induced neutropenia; however, a review of the literature produced only three reports of this reaction. Only one provided the duration of the neutropenia. To our knowledge, this case report is only the second that provides the duration of the clindamycin-induced neutropenia. Clinicians should be made aware of this potential adverse event.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…1, 2 A review of the literature surprisingly produced only three published reports of this reaction; only one provided the duration of the event. [3][4][5]…”

Section: (Pharmacotherapy 2003;23(1):101-103)mentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

mentioning

confidence: 99%

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Neutropenia After Single‐Dose Clindamycin for Dental Prophylaxis

2003

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Clindamycin

LeFrock¹,

Molavi²,

Prince³

1982

Medical Clinics of North America

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Topical Acne Drugs

Akhavan

Bershad

2003

American Journal of Clinical Dermatology

152

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This review examines the commonly available topical acne agents and factors that determine their percutaneous absorption. Reported and theoretical adverse effects from systemic exposure are detailed. The topical retinoid class, which includes tretinoin, adapalene and tazarotene, and the topical antibacterials, clindamycin and erythromycin, are regulated by prescription in most countries. Used appropriately, the above-mentioned drugs deliver, at most, miniscule amounts of active ingredient into the circulation. Clear-cut links to systemic toxicity in humans are practically nonexistent, except in the case of topical clindamycin, which has been associated with diarrhea rarely, and there have been 2 cases of pseudomembranous colitis reported. Birth defects have occurred in two patients treated with tretinoin and one patient treated with adapalene, but causation was not proven. Another prescription drug, 20% azelaic acid, is associated with relatively high systemic exposure, which is presumed innocuous because it is a normal dietary constituent whose endogenous levels are not altered by topical use. Benzoyl peroxide, salicylic acid, sulfur, and sodium sulfacetamide are available in concentrations of 2% or more in over-the-counter acne treatments and some prescription products. All of these agents are known to exhibit some degree of percutaneous absorption. They remain largely unregulated because, other than skin irritation, only local allergic contact dermatitis from benzoyl peroxide in about 2.5% of patients and rare local and systemic hypersensitivity reactions from sodium sulfacetamide have been reported. Salicylism has occurred using methyl salicylate ointments and high concentrations of salicylic acid on widespread areas of hyperkeratotic skin, but there are no known cases resulting from salicylic acid acne products. Caution is advised in special circumstances, such as during childhood, pregnancy, lactation and concomitant therapy with other drugs, because relevant studies are lacking. Animal data support avoidance of many topical agents, particularly known teratogens such as retinoids and salicylic acid, in pregnant women. Salicylate avoidance is advised during lactation, because aspirin use carries the risk of bleeding disorders in nursing infants.

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Granulocytopenia Due to Clindamycin

Cited by 4 publications

References 0 publications

Neutropenia After Single‐Dose Clindamycin for Dental Prophylaxis

Neutropenia After Single‐Dose Clindamycin for Dental Prophylaxis

Clindamycin

Topical Acne Drugs

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