Granulocytic sarcoma presenting as a large mediastinal mass with acute spinal cord compression in a non‐leukemic child

Howell, Della L.; Abramowsky, Carlos R.

doi:10.1002/pbc.20293

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…Nineteen of the spinal myeloid sarcomas were correctly diagnosed by immunohistochemical staining, including the two cases presented in this article [5,[7][8][9][10][12][13][14][17][18][19][20]25,26] . The correct and prompt diagnosis of MS was important for adequate therapy, which was often delayed because of a high misdiagnosis rate [31] .…”

Section: Discussionmentioning

confidence: 99%

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Different outcome of myeloid sarcoma with spinal cord compression preceding acute myeloid leukemia: Report of two cases and review of literatures

Yin

Zhou

Chen

et al. 2010

Chin. J. Cancer Res.

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Myeloid sarcomas (MS) preceding acute myeloid leukemia (AML) are rare, which presenting as acute spinal cord compression is even rare. Here we report two new cases of myeloid sarcoma patients, whose outcomes were different. Twenty-seven patients with spinal MS preceding AML have been reported to date, including the two cases presented in this article. Surgical decompression was performed in 25 of the 27 patients, and 23 of these received additional anti-AML therapy. Considering our patients and the published cases in the literature we suggest that immunohistochemical study plays an essential role in arriving at a correct diagnosis of MS, and that emergency surgery to resect spinal MS is an available treatment to make neural function recovery, and that the disease must be treated with intensive chemotherapy similar to that used to treat AML as soon as possible after resection or irradiation of the tumor.

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Section: Discussionmentioning

confidence: 99%

“…Surgical decompression was performed in 25 of the 27 patients, including the two cases presented [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][24][25][26][27] . MS is a malignant tumor, and its growth speed is fast.…”

Section: Discussionmentioning

confidence: 99%

Different outcome of myeloid sarcoma with spinal cord compression preceding acute myeloid leukemia: Report of two cases and review of literatures

Yin

Zhou

Chen

et al. 2010

Chin. J. Cancer Res.

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“…7,8,12,13,16,21,[23][24][25] Nine of the 10 patients were males, and the mean age was 11 years. The male predominance might be associated with the higher incidence of AML in males.…”

Section: Discussionmentioning

confidence: 99%

Spinal Epidural Granulocytic Sarcoma in a Child Precedent to Clinical Manifestation of Acute Myeloid Lymphoma -Case Report-

Takeda

Yamaguchi

Eguchi

et al. 2009

Neurol. Med. Chir.(Tokyo)

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A 13-year-old boy presented with an epidural thoracic granulocytic sarcoma manifesting as rapidly progressive paraplegia preceding clinical manifestation of acute myeloid leukemia (AML). Magnetic resonance imaging revealed a thoracic epidural tumor. He underwent emergent laminectomy and the tumor was totally resected. The initial histological diagnosis was malignant lymphoma. The correct diagnosis of epidural granulocytic sarcoma and AML was established based on cell-surface markers and a chromosomal study of the bone marrow cells. A combination of chemotherapy and bone marrow transfusion achieved complete remission of leukemia. No evidence of AML has emerged over the 18-month follow-up period. Granulocytic sarcoma should be considered in the differential diagnosis of an epidural mass in pediatric patients with or without acute leukemia. Immediate diagnosis and appropriate treatment are recommended to prevent leukemic transformation.

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“…2,[5][6][7][9][10][11][12]14,[16][17][18][19][20][21][22][23][24][25][26][27][28]30) The male predominance could be associated with the higher incidence of acute myeloid leukemia in men. 4) The affected sites included two cases at cervical, 17 at thoracic, 10 at lumbar, and three at sacral spinal levels.…”

Section: Discussionmentioning

confidence: 99%

“…13) Granulocytic sarcoma most commonly occurs in the soft tissues of the head and neck, bone, and skin, 9) and less often in the central nervous system and spinal cord. 2,[5][6][7][9][10][11][12][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]30) Granulocytic sarcoma seldom manifests before the identification of leukemia in the peripheral blood or bone marrow. 2,[5][6][7][9][10][11][12][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]30) The finding of granulocytic sarcoma in p...…”

Section: Introductionmentioning

confidence: 99%

Spinal Granulocytic Sarcoma Manifesting as Radiculopathy in a Nonleukemic Patient -Case Report-

Inoue

Takahashi

Shimizu

et al. 2008

Neurol. Med. Chir.(Tokyo)

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A 26-year-old nonleukemic woman presented with lumbosacral granulocytic sarcoma manifesting as progressive low back pain and numbness of her left lower leg persisting for 3 months. Physical examination revealed hypesthesia within the left S1 area of the sensory dermatome, decreased Achilles tendon reflex in the left lower extremity, and walking impairment due to severe pain in her left hip and leg. Magnetic resonance imaging confirmed an extradural mass in the spinal canal at the L5-S2 levels with invasion to the pelvis from the left sacral foramen. Positron emission tomography with [ 18 F]fluorodeoxyglucose (FDG-PET) showed hyperaccumulation indicating malignant tumor. Baseline laboratory data were normal. Decompressive laminectomy and tumor removal were performed. Histological examination identified granulocytic sarcoma. Bone marrow involvement was absent. She underwent adjuvant chemotherapy and radiotherapy, resulting in reduced residual lesion and neurological improvement. Immediate diagnosis and adequate systematic treatment are recommended for spinal granulocytic sarcoma in nonleukemic patients to prevent or delay progression to leukemia. The importance of immunohistochemical staining in the differential diagnosis from other types of spinal tumor, and the efficacy of FDG-PET for evaluation of the treatment are also emphasized.

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Granulocytic sarcoma presenting as a large mediastinal mass with acute spinal cord compression in a non‐leukemic child

Cited by 8 publications

References 6 publications

Different outcome of myeloid sarcoma with spinal cord compression preceding acute myeloid leukemia: Report of two cases and review of literatures

Different outcome of myeloid sarcoma with spinal cord compression preceding acute myeloid leukemia: Report of two cases and review of literatures

Spinal Epidural Granulocytic Sarcoma in a Child Precedent to Clinical Manifestation of Acute Myeloid Lymphoma -Case Report-

Spinal Granulocytic Sarcoma Manifesting as Radiculopathy in a Nonleukemic Patient -Case Report-

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