Granulocytic sarcoma of the rectum: Report of one case that presented with rectal bleeding

Abstract

Granulocytic sarcoma is an uncommon and localized extramedullary tumor composed of immature granulocytic cells. It may present in association with acute myeloid leukaemia, myelodysplastic syndrome and chronic myelogenous leukaemia. Granulocytic sarcoma may occur in any anatomical site but involvement of the gastrointestinal tract is rare, especially in the rectum. We report on the case of a 17 year old female who presented with rectal bleeding, abdominal pain and weight loss one mo prior to admission. Rectosigmoidoscopy revealed a rectal polypoid and ulcerated mass. The histological examination of the mass showed granulocytic sarcoma. Bone marrow examination was compatible with acute promyelocytic leukaemia (FAB type M3). This case report is a reminder of this peculiar sign of tumoral syndrome in acute myeloid leukaemia. We also discuss diagnostic methods and analyze the disease course.

Leukemia in gastrointestinal organs as cause of treatment failure: 378 cases analyzed

“…An additional patient with small bowel tumor had relapse in both marrow and organ sites and was well 2 years after salvage chemotherapy and autologous transplant . Of the 52 patients who did not undergo local treatment, 9 were reportedly surviving with response after chemotherapy alone for 2 to 10 years . Three of the long survivors had also had stem cell transplants: one after pancreatic tumor, one after duodenal tumor, and one after retroperitoneal tumor that compressed duodenum .…”

Granulocytic sarcoma: An uncommon cause of systemic inflammatory response syndrome

“…Gastrointestinal GS usually involves the small intestine presenting with abdominal pain and obstruction and has been managed successfully using both laparoscopic‐assisted and open surgical approaches . Other rare presentations include GS presenting as a rectal mass and GS causing spinal cord compression . Biliary manifestations GS have been reported on 4 occasions in the literature with extramedullary myeloid tumor (EMMT) of the gallbladder and 2 cases of GS of the pancreas and GS of the porta hepatis causing obstructive jaundice demonstrated on autopsy .…”

“…It may present in association with acute myeloid leukemia, myelodysplastic syndrome, and chronic myelogenous leukemia. 1 With the presentation of this rare case, we review relevant literature and discuss the importance of early diagnosis and management of GS.…”

A rare cause of mechanical obstruction: Intestinal myeloid sarcoma

“…Miyeloid sarkom (MS) agresif seyirli nadir görülen bir tümördür (1). Ekstramedüller immatür miyeloid hücrelerden kaynaklanır (1,2).…”

“…Ekstramedüller immatür miyeloid hücrelerden kaynaklanır (1,2). İlk olarak Burns tarafından 1811'de tanımlandı ve daha sonra King tarafından miyeloperoksidaz ile yeşil boyandığı için kloroma olarak isimlendirildi (3,4).…”