Granulocytic Sarcoma of Parotid Gland in a 4-Year-Old Child with Subleukemic AML: A Diagnostic Challenge!

Ingale, Yashwant; Patil, Tushar; Chaudhari, Priyanka; Routray, Samapika; Agrawal, Manoj Kumar

doi:10.1155/2013/321289

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…The involvement of MS in the salivary gland is extremely rare, and we identified 17 cases in 13 published reports, including 10 case reports [11–20] and three retrospective reviews [21–23], including this case. Table 1 summarizes the clinical features of MS involving the salivary gland.…”

Section: Resultsmentioning

confidence: 99%

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Shim

Kim

et al. 2019

BioMed Research International

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Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. A 62-year-old man was initially diagnosed with carcinoma that arose in a sebaceous lymphadenoma in the parotid gland, through a total parotidectomy with neck dissection. After an extensive histopathological review that included immunohistochemistry, a pathologic diagnosis of MS with infiltration into the sebaceous lymphadenoma with concurrent BM involvement was confirmed. MS is difficult to diagnose accurately; herein, we analyzed the clinical presentations and effectiveness of the various diagnostic methods with a review of the literature. There are 17 cases, including our case, reported in 13 studies. Of the cases in which the salivary glands were affected, 10 involved the parotid gland, six involved the submandibular gland, and one involved both. Isolated invasion of the salivary gland was found in one case of parotid gland invasion and three cases of submandibular gland invasion. In 13 cases, the salivary glands were affected by various other lesions. Although there were no incidences of isolated MS, six patients were diagnosed with secondary MS and eight patients with MS with BM involvement, including this case. The diagnosis of MS is difficult given its rarity, and a high index of suspicion and integrated radiologic and careful histopathologic evaluation are required. Most cases of MS infiltrating the salivary gland might be indicated by the possibility of BM involvement. MS with BM involvement predicts poor prognosis and the need for intensive systemic treatment.

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Section: Resultsmentioning

confidence: 99%

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Shim

Kim

et al. 2019

BioMed Research International

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“…2 Our literature search on PubMed with the following key-words "myeloid sarcoma," "granulocytic sarcoma," "chloroma," "extramedullary myeloid tumor," "salivary gland," and "parotid gland," revealed only 18 cases mentioned in 11 case reports and three retrospective reviews (Table 2). [2][3][4][5][6][7][8][9][10][11][12][13][14][15] Our search was limited to English language reports. Any report of GS originating from a lymph node without salivary gland involvement was excluded.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Granulocytic Sarcoma of the Parotid in Chronic Myeloid Leukemia: A Case Report and Literature review

Chatterjee,

Hiwale,

Vagha

2024

F1000Res

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Granulocytic sarcomas are infrequent, extramedullary malignant occurrences, generally seen with or secondary to acute myeloid leukemia (AML). Their association with chronic myeloid leukemia (CML) is rare and their appearance in parotid gland is sparsely reported in the literature, as per our literature search. In this report, we present an unusual and rare case of imatinib resistant BCR-ABL1 positive secondary granulocytic sarcoma to CML in chronic phase. The rarity of this clinical presentation presents a diagnostic dilemma, which required the pathologist and the clinician to combine a strong clinical suspicion with cytopathological features to diagnose this case, in order to ensure timely therapeutic modifications (shift from imatinib to second-generation tyrosine kinase inhibitor), considering the improvements in prognosis of imatinib resistant granulocytic sarcomas.

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“…9 Ingale et al in 2013 described the peripheral blood smear findings in subleukemic leukemia which revealed an increase number of blast cells primarily monoblast and myeloblast in myeloperoxidase staining. 17 Shingade et al in 2016 did bone marrow evaluation in leukemic patients and observed 2 cases of subleukemic leukemia, with incidence of 3.17 percent. All their cases were of AML M2 type.…”

Section: Discussionmentioning

confidence: 99%

“…It is advised to administer along with corticosteroids to prevent depression, malaise and appetite loss associated with cytarabine medication. 17 Prompt supportive care with medicines is advisable to stop and prevent infection. Chemotherapy is frequently used to reduce the amount of aberrant blood cells or to promote the growth of normal cell lines.…”

Section: Discussionmentioning

confidence: 99%

Subleukemic leukemia presenting as pancytopenia in an elderly female with mild constitutional symptoms: A rare case report

Akhtar¹,

Fahim

Hasan³

et al. 2022

JDPO

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Subleukemic leukemia is characterized by the presence of atypical or abnormal white blood cells in peripheral blood with total leukocyte count in within normal range. The clinical features are nonspecific and include fever, fatigue, and weight loss, vague bone pain, bruising or bleeding. We present a rare case of subleukemic leukemia presenting as pancytopenia in a 55 years female, who presented with mild constitutional symptoms of generalized weakness, easy fatiguability and loss of appetite for the past 3 months. We should be aware of this rare finding of subleukemic leukemia in patients with mild constitutional symptoms and keep it in the differentials of a case of pancytopenia, for prompt diagnosis and early initiation of treatment, with better outcome.

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Granulocytic Sarcoma of Parotid Gland in a 4-Year-Old Child with Subleukemic AML: A Diagnostic Challenge!

Cited by 4 publications

References 4 publications

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Case Report: Granulocytic Sarcoma of the Parotid in Chronic Myeloid Leukemia: A Case Report and Literature review

Subleukemic leukemia presenting as pancytopenia in an elderly female with mild constitutional symptoms: A rare case report

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