Granulocytic Sarcoma in a Patient With Blast Crisis Mimicking a Chronic Subdural Hematoma

O’Brien, Caitlin E.; Saratsis, Amanda; Voyadzis, Jean Marc

doi:10.1200/jco.2010.33.1272

Cited by 14 publications

(4 citation statements)

References 21 publications

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“…We found only three other reports of MS presenting acutely as an extra-axial lesion, only two of which involved the subdural space [5][6][7]. Common to all cases was a history negative for trauma and prior or ongoing leukemia.…”

Section: Discussionmentioning

confidence: 86%

Wolf in Sheep’s Clothing: Acute Chloroma Disguised as a Subdural Hematoma

et al. 2011

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Section: Discussionmentioning

confidence: 86%

Wolf in Sheep’s Clothing: Acute Chloroma Disguised as a Subdural Hematoma

et al. 2011

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“…Patients presenting with metastatic granulomatous tumors usually present with typical symptoms of myeloproliferative disease along with Local pain (78%), tumor nodules (65%), and sensory disturbances (52%) [ 5 ]. The occurrence of spinal cord compression has also been explained most commonly seen in thoracic spine causing back and radicular leg pain [ 6 , 7 ]. Granulocytic sarcomas of leukemic origin usually tend to invade the periosteum through the Haversian canals and then spread to the dura mater [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Chloroma – A Rare Case of Metastatic Tumor to Dorsal Spine in Patient of Chronic Myeloid Leukemia Causing Acute Paraparesis

Nair¹,

Kundnani²,

Shetty³

et al. 2023

JOCR

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Introduction: Chloromas are defined as metastatic granulocytic solid tumors of myeloid origin occurring at an extramedullary site. In this case report, we present an uncommon case of chronic myeloid leukemia (CML) presenting with metastatic sarcoma to the dorsal spine causing acute paraparesis. Case Report: A 36-year-old male presented in the OPD with complaints of progressive upper back pain and acute paraparesis since a 1 week. The patient is a previously diagnosed case of CML on treatment for the same. MRI of the dorsal spine indicated extradural soft-tissue lesions in D5-D9 extending to the right side of the spinal canal displacing the cord to the left. Considering the acute paraparesis that the patient developed, he was taken for an emergency decompression of the tumor. Microscopy showed infiltration of fibrocartilaginous tissue of polymorphous origin mixed with atypical myeloid precursor cells. Immunohistochemistry reports show atypical cells diffusely expressing myeloperoxidase, focally expressing CD34 and CD117. Conclusion: Rare case reports like this are the only literature available on remission in CML cases with sarcomas. The acute paraparesis in our patient was prevented from increasing to a paraplegia by surgical means. Immediate decompression of the spinal cord in patients with paraparesis and associated radiotherapy and chemotherapy should be considered in all patients with myeloid sarcomas of CML origin. While examining patients of CML, the possibility of a granulocytic sarcoma should always be kept in mind. Keywords: Chronic myeloid leukemia, chloroma, spinal metastasis.

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“…There are reports in the literature of GS mimicking intracranial hematoma. [13][14][15] O'Brien et al 15 describe a case of a 34-year-old presenting with acute altered mental status for 1 day found to have a subdural collection. The collection was biopsied and found to be consistent with GS.…”

Section: Discussionmentioning

confidence: 99%

Granulocytic Sarcoma of the Orbit Presenting as a Fulminant Orbitopathy in an Adult With Acute Myeloid Leukemia

O’Neill¹,

Harrison²,

Cameron³

et al. 2017

Ophthalmic Plastic &Amp; Reconstructive Surgery

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A 64-year-old woman with relapsed acute myelogenous leukemia (AML) undergoing salvage chemotherapy developed rapid onset of right-sided ophthalmoplegia, proptosis, optic neuropathy, and vision loss from 20/30 to hand motions over a 3-hour period on day 4 of her treatment. CT scan of her orbits revealed a superolateral orbital mass and periocular edema. She underwent immediate canthotomy and cantholysis, and lateral orbitotomy with debulking of the mass later the same day. The histopathology was consistent with aggregates of myeloid blasts. Her vision recovered to 20/20 on postoperative day 1. Orbital granulocytic sarcoma is a rare condition often concurrent with AML, typically in the pediatric population and rarely in adults. Presentation as a fulminant orbitopathy with rapidly progressive optic neuropathy and vision loss over several hours has not been previously reported.

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Granulocytic Sarcoma in a Patient With Blast Crisis Mimicking a Chronic Subdural Hematoma

Cited by 14 publications

References 21 publications

Wolf in Sheep’s Clothing: Acute Chloroma Disguised as a Subdural Hematoma

Wolf in Sheep’s Clothing: Acute Chloroma Disguised as a Subdural Hematoma

Chloroma – A Rare Case of Metastatic Tumor to Dorsal Spine in Patient of Chronic Myeloid Leukemia Causing Acute Paraparesis

Granulocytic Sarcoma of the Orbit Presenting as a Fulminant Orbitopathy in an Adult With Acute Myeloid Leukemia

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