Granulocytic maturation in cultures of acute myeloid leukemia is not always accompanied by increased apoptosis

Garattini, Enrico; Terao, Mineko

doi:10.1016/j.leukres.2005.09.011

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…The apoptotic percentage in ATRA-treated cells increased to approximately 7.5 %. Retinoic acid has been reported to induce extrinsic apoptosis mediated by TRAIL induction and subsequent caspase-3 activation [28,29]. In addition, caspase-independent apoptosis mediated by calpain was also reported in human neutrophil [30].…”

Section: Upr-requirement For Cell Survival During Neutrophil Differenmentioning

confidence: 99%

Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation

Tanimura

Miyoshi

Horiguchi

et al. 2018

Cell Physiol Biochem

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Background/Aims: Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) are involved in hematopoietic differentiation. However, the mechanistic linkage between ER stress/UPR and hematopoietic differentiation remains unclear. Methods: We used bipotent HL-60 cells as an in vitro hematopoietic differentiation system to investigate the role of ER stress and UPR activity in neutrophil and macrophage differentiation. Results: The in vitro differentiation analysis revealed that ER stress decreased during both neutrophil and macrophage differentiations, and the activities of PERK and ATF6 were decreased and that of IRE1α was increased during neutrophil differentiation in a stage-specific manner. By contrast, the activities of ATF6 and ATF4 decreased during macrophage differentiation. When the cells were treated with oligomycin, the expression of CD11b, a myelocytic differentiation marker, and morphological differentiation were suppressed, and XBP-1 activation was inhibited during neutrophil differentiation, whereas CD11b expression was maintained, and morphological differentiation was not obviously affected during macrophage differentiation. Conclusion: In this study, we demonstrated that neutrophil differentiation is regulated by ER stress/UPR that is supported by mitochondrial ATP supply, in which IRE1α-XBP1 activation is essential. Our findings provide the evidence that mitochondrial energy metabolism may play a critical role in neutrophil differentiation.

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Section: Upr-requirement For Cell Survival During Neutrophil Differenmentioning

confidence: 99%

Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation

Tanimura

Miyoshi

Horiguchi

et al. 2018

Cell Physiol Biochem

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“…CCL3 and CCL4 are implicated in neutrophil recruitment [49]. CCL4, GM-CSF, hypoxia inducible factor 1, CFLAR [50] and an MIF act as neutrophil survival factors [51]. In a different study, RANTES and IP-10 (CXCL10) enhanced the ability of DC to recruit T cells thereby inducing effective mycobacterial killing [52].…”

Section: Innate Immune Responsementioning

confidence: 99%

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Beisiegel¹,

Mollenkopf²,

Hahnke³

et al. 2009

Eur J Immunol

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Progression and outcome of tuberculosis is governed by extensive crosstalk between pathogen and host. Analyses of global changes in gene expression during immune response to infection with Mycobacterium tuberculosis (M.tb) can help identify molecular markers of disease state and progression. Global distribution of M.tb strains with different degrees of virulence and drug resistance, especially for the immunocompromised host, make closer analyses of host responses more pressing than ever. Here, we describe global transcriptional responses of inducible nitric oxide synthase-deficient (iNOS -/-) and WT mice infected with two related M.tb strains of markedly different virulence, namely the M.tb laboratory strains H37Rv and H37Ra. Both hosts exhibited highly similar resistance to infection with H37Ra. In contrast, iNOS -/-mice rapidly succumbed to H37Rv, whereas WT mice developed chronic course of disease. By differential analyses, virulence-specific changes in global host gene expression were analyzed to identify molecular markers characteristic for chronic versus acute infection. We identified several markers unique for different stages of disease progression and not previously associated with virulencespecific host responses in tuberculosis.

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Retinoids

Dawson¹

2010

Burger's Medicinal Chemistry and Drug Discovery

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Retinoid drugs find major applications in the topical treatment of cutaneous proliferative disorders such as acne, psoriasis, and photoaging and cutaneous cancers such as cutaneous T‐cell lymphoma (CTCL) and Kaposi's sarcoma. Oral retinoids are successfully used to treat nodular/cystic acne, systemic CTCL, and acute promyelocytic leukemia. This overview of available retinoid drugs and those in the preclinical or clinical pipeline covers their development, indications, clinical trial results, adverse effects, and pharmacology/metabolism. Retinoids have been described historically and functionally in the context of interaction with their nuclear receptors—retinoic acid receptors (RARs) and retinoid X receptors (RXRs)—in inducing gene transcription. RAR‐selective retinoids or their prodrugs include first‐generation all‐ trans ‐retinoic acid (tretinoin) and its 13‐ cis isomer (isotretinoin), and second‐generation acitretin and its ethyl ester (etretinate), both having an aromatic 2,3,6‐trimethyl‐4‐methoxyphenyl terminus. Third‐generation more aromatic analogs include ethyl ester tazarotene (Tazorac®) and adapalene (Differin®), both selective for RAR subtypes β and γ, and RARα‐selective pipeline candidates Am80 and NRX 195183, which are in clinical trials. RAR and RXR transcriptional panagonist 9‐ cis ‐retinoic acid is next and is followed by RXR‐selective bexarotene (Targretin™) and two RXR‐selective clinical trial candidates, 9cUAB and NRX 194204. The fourth generation includes three compounds that may have applications in the treatment or prevention of cancer. While originally considered as retinoids, such as N ‐(4‐hydroxyphenyl) retinamide, or as retinoid‐related or derived, such as ST1926 (AHPC) and SHetA2, they subsequently were found to function independently of the RARs and RXRs in inhibiting cancer cell proliferation and inducing apoptosis.

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Granulocytic maturation in cultures of acute myeloid leukemia is not always accompanied by increased apoptosis

Cited by 3 publications

References 14 publications

Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation

Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Retinoids

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