Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: A new mechanism of action for SHP-2

Richard, Manon; Thibault, Nathalie; Veilleux, Patricia; Gareau-Pagé, Geneviève; Beaulieu, André

doi:10.1016/j.molimm.2005.10.006

Cited by 52 publications

(45 citation statements)

References 25 publications

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“…15,40 Previous observations in neutrophils had shown the tyrosine-phosphorylated ITIM of DCIR to bind to SHP-1 and SHP-2. 16 Our results suggest that ligation of DCIR by HIV-1 also leads to SHP-1 and SHP-2 activation, because blocking them either with an inhibitor or with antisense oligonucleotides causes a significant diminution in HIV-1 binding/entry and virus infection. It is noteworthy that SHP-1 can be a substrate of PKC-␣.…”

Section: Discussionmentioning

confidence: 70%

“…16 We thus next assessed whether Src, Tec, and Syk TKs were responsible for this process. The possible involvement of Src TKs was assessed using the specific inhibitor PP2.…”

Section: Src and Syk Family Members Are Involved In The Hiv-1-mediatementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…15 In the case of DCIR, one study has demonstrated that, when phosphorylated, it recruits both SHP-1 and SHP-2. 16 Nevertheless, there is still no evidence of the possible recruitment of phosphatases and/or tyrosine kinases (TKs) after engagement of DCIR by HIV-1.Although a previous work demonstrated that DCIR is involved in the interaction between HIV-1 and DCs, 10 nothing is known on the precise contribution of DCIR-mediated intracellular signal transducers in virus capture, infection, and eventual transfer. The possible interaction between its ITIM with non-receptor TKs (NRTKs) and protein tyrosine phosphatases (PTPs) in this process also deserves some attention.…”

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confidence: 99%

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DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway

Lambert

Barabé

Gilbert

et al. 2011

Blood

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Dendritic cell immunoreceptor (DCIR) is IntroductionIt is known that cell-free virions do not efficiently cross genital epithelial cells. Instead HIV-1 uses primarily dendritic cells (DCs) to penetrate the mucosal epithelium. 1,2 The virus is then transferred and disseminated from this entry site to T-cell zones in secondary lymphoid organs, where it can productively infect residing CD4 ϩ T cells. The infection process causes a marked depletion of CD4 ϩ T cells, 3 progressive impairment of the immune system, as well as chronic hyperactivation of both CD4 ϩ and CD8 ϩ T cells. 4 The initial attachment step of HIV-1 to DCs may occur through several complex interactions between the virus and the target cell surface (reviewed in Clapham and McKnight 5 and in Ugolini et al 6 ) such as the association between the oligosaccharides found on the external envelope glycoprotein gp120 and the mannose receptor (CD206), langerin (CD207), or 8 This will result in virus capture and transmission to CD4 ϩ T cells in an effective trans mode 9 (ie, transfer of virions bound onto DCs and/or localized in endosomes). Another lectin receptor, that is, the dendritic cell immunoreceptor (DCIR), can behave as an HIV-1 attachment factor for HIV-1 to participate actively in trans infection of CD4 ϩ T cells. 10 DCIR also contributes to cis-infection events, that is, infection of surrounding CD4 ϩ T cells by virions produced by DCs productively infected with HIV-1. 10 DCIR is a member of a recently described family of C-type lectin receptors (CLRs), which includes DCAR, dectin-2, BDCA-2, MCL, and MINCLE. These receptors carry a single carbohydrate recognition domain (CRD) at the COOH terminal and generally lack consensus signaling motifs in their cytoplasmic region. 11 Several members of the family, however, possess a positively charged residue in their transmembrane region, via which they associate with immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules, such as the Fc receptor ␥ chains. Importantly, DCIR is the only family member harboring an immunoreceptor tyrosine-based inhibitory motif (ITIM), which is involved in modulation of cellular responses. 12 DCIR is expressed on the surface of most antigen-presenting cells (ie DCs, monocytes, macrophages, and B cells), as well as on granulocytes, and it is differentially expressed depending on the DC maturation status. 13 Lipopolysaccharide, IL-4, and TNF-␣ down-regulate DCIR expression on neutrophils. 14 The ITIM domain of DCIR contains the consensus sequence S/I/V/LxYxxI/V/L, including a tyrosine residue at position 7 (ie, ITYAEV). 13 Generally, when ITIM-containing receptors are engaged, they become tyrosine-phosphorylated and then transmit signals by binding and activating Src homology-2 domain (SH2)-containing tyrosine phosphatases (eg, SHP-1 and SHP-2) and/or the SH2-containing tyrosine inositol phosphate (SHIP). 15 In the case of DCIR, one study has demonstrated that, when phosphorylated, it recruits both SHP-1 and SHP-2. 16 Nevertheless, there is still no e...

show abstract

Section: Discussionmentioning

confidence: 70%

“…16 We thus next assessed whether Src, Tec, and Syk TKs were responsible for this process. The possible involvement of Src TKs was assessed using the specific inhibitor PP2.…”

Section: Src and Syk Family Members Are Involved In The Hiv-1-mediatementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway

Lambert

Barabé

Gilbert

et al. 2011

Blood

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“…This motif directly associates with deactivating phosphatases in its cytoplasmic part, suggesting an inhibitory signalling function. [1][2][3] Evidence from three different species suggests that DCIR is an important etiological factor in arthritis. First, both arthritis and autoimmunity in the rat associates with a gene complex encoding C-type lectin-like receptors, including several copies of rat DCIR.…”

Section: Introductionmentioning

confidence: 99%

Differential expression of transcripts for the autoimmunity-related human dendritic cell immunoreceptor

et al. 2008

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Dendritic cell immunoreceptor (DCIR) deficiency is related to development of autoimmune disorders and DCIR gene polymorphisms are associated with rheumatoid arthritis (RA). We analyzed the mRNA expression from the four known transcripts of DCIR in IFN-g-treated human leukocytes together with fine mapping across the locus. RA patients and healthy controls were genotyped for several single nucleotide polymorphisms (SNPs) in DCIR and flanking regions. mRNA expression in peripheral blood mononuclear cells (PBMCs), stimulated with gamma-interferon (IFN-g) in vitro, was determined by transcript-specific PCR. Our data reveal that IFN-g significantly downregulates the average expression of transcripts DCIR_v1, DCIR_v2, DCIR_v3 and DCIR_v4 (Po0.0001 for v1, Po0.02 for v2, Po0.0001 for v3, Po0.001 for _v4, patients and controls, Wilcoxon signed-rank). The expression of DCIR showed significant association with variations in the gene. Cells with the RAassociated allele rs2024301 exhibit a significant increase in the expression of DCIR_v4. We also present a new fifth isoform lacking exons 2, 3 and 4. This data illustrate that common genetic variations may influence DCIR mRNA expression. We also show that the expression is regulated by the inflammatory mediator IFN-g, affecting all four transcripts and that this was independent of genotype.

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Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice

et al. 2017

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Upon injection of D-galactosamine and lipopolysaccharide, Dcir1 -/-mice showed decreased mortality rates and serum levels of alanine aminotransferase (ALT). In early onset hepatitis, serum levels of TNF-α, which primarily cause inflammation and hepatocyte apoptosis, were significantly lower in Dcir1 -/-mice than in wild type (WT) mice. In the liver of Dcir1 -/-mice, influx of neutrophils and other leukocytes decreased.Consistently, the levels of neutrophil-chemoattractant chemokine CXCL1/KC, but not CXCL2/MIP-2, were lower in Dcir1 -/-mice than in WT mice. However, chemotaxis of Ishiguro and Fukawa et.al.3

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Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: A new mechanism of action for SHP-2

Cited by 52 publications

References 25 publications

DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway

DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway

Differential expression of transcripts for the autoimmunity-related human dendritic cell immunoreceptor

Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice

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