Granulocyte Macrophage Colony–Stimulating Factor Expression in Human Herpetic Stromal Keratitis: Implications for the Role of Neutrophils in HSK

Duan, Rui; Remeijer, Lies; Dun, Jessica M. van; Osterhaus, Albert D. M. E.; Verjans, Georges M. G. M.

doi:10.1167/iovs.06-0053

Cited by 33 publications

(22 citation statements)

References 42 publications

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“…Neutrophils are non-specific cytotoxic immunocytes that exclude infecting organisms. Recently, it has been reported that neutrophils also have antitumor effects mediated through ADCC via phagocytosis, elastase, or superoxide (27)(28)(29). ADCC is triggered by tumorspecific antibodies and Fc receptor-expressing cytolytic cells such as NK cells, neutrophils, eosinophils, and monocytes/ macrophages (30).…”

Section: Discussionmentioning

confidence: 99%

Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer

Hoshi

Sawada

Uchida³

et al. 2011

Int J Oncol

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Abstract. MUC5AC, a high molecular weight glycoprotein, is overexpressed in the ductal region of human pancreatic cancer but is not detectable in the normal pancreas, suggesting its association with disease development. In the present study, we investigated the in vitro and in vivo effects of MUC5AC knockdown by short interfering RNA (siRNA) in the MUC5AC-overexpressing SW1990 and BxPC3 human pancreatic cancer cell lines in order to clarify its function. Significant decreases in the expression levels of MUC5AC mRNA and protein were observed in SW1990 and BxPC3 cells that had been stably transfected with a MUC5AC siRNA expression vector (SW1990/si-MUC5AC and BxPC3/si-MUC5AC cells) compared to those in cells transfected with an si-mock vector (SW1990/si-mock and BxPC3/si-mock cells). In in vitro studies, neither type of MUC5AC-knockdown cell showed any difference in cell survival, proliferation, or morphology from the si-mock cells or parental cells. However, in vivo xenograft studies demonstrated that MUC5AC knockdown significantly reduced the tumorigenicity and suppressed the tumor growth of si-MUC5AC cells compared to those of the si-mock cells. Immunohistochemical analysis revealed that CD45R/B220 + and Gr-1 + cells had infiltrated into the tumor tissue of the SW1990/si-MUC5AC cells. Furthermore, cancer-associated antigen specific antibodies were detected at high levels in the sera from the SW1990/si-MUC5AC cell-bearing mice. These results suggest that tumorassociated MUC5AC expressed on the surface of pancreatic cancer cells supports the escape of pancreatic cancer cells from immunosurveillance. The present findings highlight a new dimension of MUC5AC as a functional immunosuppressive agent and its important role in pancreatic cancer progression.

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Section: Discussionmentioning

confidence: 99%

Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer

Hoshi

Sawada

Uchida³

et al. 2011

Int J Oncol

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“…Interleukin 17 (IL-17) and granulocyte macrophage colony stimulatory factor (GM-CSF) have a critical role in this process [7].…”

Section: Discussionmentioning

confidence: 99%

Anti-VEGF monoclonal antibody-induced regression of corneal neovascularization and inflammation in a rabbit model of herpetic stromal keratitis

Saravia

Zapata

Ferraiolo

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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“…It has been shown that plant sterols have antiinflammatory properties and immune modulating effects on subsets of CD4+ T cells and a notable pharmacological activity against rheumatoid arthritis, which shares pathogenic mechanisms and cell types involved with HSK [18,19].…”

Section: Discussionmentioning

confidence: 99%

The in vitro immunomodulatory activity of a synthetic brassinosteroid analogue would account for the improvement of herpetic stromal keratitis in mice

Michelini

Berra

Alché

2008

The Journal of Steroid Biochemistry and Molecular Biology

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Granulocyte Macrophage Colony–Stimulating Factor Expression in Human Herpetic Stromal Keratitis: Implications for the Role of Neutrophils in HSK

Abstract: The data suggest that GM-CSF, expressed by cornea-resident cells such as HCFs and HCE cells, may play a role in the immunopathogenesis of HSK by prolonging the survival and modulating the effector function of corneal infiltrating neutrophils.

Cited by 33 publications

References 42 publications

Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer

Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer

Anti-VEGF monoclonal antibody-induced regression of corneal neovascularization and inflammation in a rabbit model of herpetic stromal keratitis

The in vitro immunomodulatory activity of a synthetic brassinosteroid analogue would account for the improvement of herpetic stromal keratitis in mice

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