Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer

As new research reveals, granulocyte colony-stimulating factor (G-CSF) plays an effective role in pregnancy success, considering that it not only affects the embryo implantation and ovarian function but also it promotes endometrial thickening and improves the pathophysiology of endometriosis, which all fundamentally lead to reducing pregnancy loss. In this review, we focus on the role of G-CSF in human reproduction. We summarized its role in ovulation, luteinized unruptured follicle syndrome, poor responders, improving repeated in vitro fertilization failure, endometrial receptivity and treatment of thin endometrium, and recurrent spontaneous abortion.

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“…Improving endometrial thickness after administering of G-CSF will probably increase the chance of pregnancy. [ 36 ]…”

Section: Role Of Granulocyte Colony-stimulating Factor In Endometrialmentioning

confidence: 99%

Role of granulocyte colony-stimulating factor in human reproduction

2018

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“…Other studies have also reported results that are aligned with the current investigation in some aspects (improved endometrial thickness) and not in others (pregnancy rate). Kunicki et al . reported an improvement in endometrium thickness but not any improvement in the rates of clinical pregnancy or live births after infusion with G‐CSF.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic role of granulocyte macrophage colony‐stimulating factor (GM‐CSF) in patients with persistent thin endometrium: A prospective and randomized study

Mao

Zhang

Cai

et al. 2020

Intl J Gynecology & Obste

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Objective To assess the effect of granulocyte macrophage colony‐stimulating factor (GM‐CSF) on unresponsive thin (<7 mm) endometrium in women undergoing frozen‐thawed embryo transfer. Methods A single‐center, randomized, prospective study enrolled 304 women with thin unresponsive endometrium from Shanghai Ninth People's Hospital between March 2017 and May 2018. Of them, 161 patients received an intrauterine infusion of GM‐CSF and 143 patients served as controls. After hysteroscopy, a gel with or without GM‐CSF was administered to fill the uterine cavity completely or up to 5 mL only. The primary outcome was confirmed pregnancy and secondary outcomes included endometrial thickness and implantation rate. Results Patients who were administered GM‐CSF had a significantly higher chemical pregnancy rate (35.3% vs 20.0%; P=0.009) and clinical pregnancy rate (28.6% vs 13.3%; P=0.005) compared with patients in the control group. Patients treated with GM‐CSF had significantly higher endometrial thickness compared with controls (7.83 ± 1.45 mm vs 7.37 ± 0.70 mm, P=0.003). Conclusion GM‐CSF therapy can effectively increase endometrial thickness and improve the clinical pregnancy rate in patients with persistent thin endometrium. The therapeutic role of GM‐CSF for infertile women under in vitro fertilization and embryo transfer (IVF‐ET) treatment can be further explored. Chinese Clinical Trial Register ChiCTR‐IPR‐17011242

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“…The increase in pregnancy rate was not significant. Kunicki [2] stimulation can increase the thickness of endometrium in patients with thin endometrial infertility and increase the pregnancy rate. Our study found that the vascular smooth muscle technology combined with estrogen treatment significantly thickened the endometrium, and the endometrial changes did not change after estrogen treatment alone, obvious or almost no change; 13 cases of successful pregnancy and childbirth in the study group, 5 cases of biochemical pregnancy; 50 patients in the control group did not reach the embryo transfer standard due to endometrial thickness after treatment, neither of them were transplanted, and the pregnancy rate in the study group was obvious improve.…”

Section: Discussionmentioning

confidence: 99%

“…At present, the clinical treatment methods of thin endometrium are mainly drug treatment and surgical treatment. High-dose estrogen treatment is the most common clinically used drug treatment, but the therapeutic effect is still controversial, some patients still have no obvious curative effect, the treatment method showed a lack of response [2] , and was eventually informed that there might be no fertility opportunities. Finding new and effective treatments is an urgent task for patients, family members and medical workers.…”

Section: Introductionmentioning

confidence: 99%

Discussion on the Efficacy of Vascular Smooth Muscle Technology in the Treatment of Thin Endometrial Infertility

sun¹,

wang²

2020

Preprint

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Objective: To clarify the efficacy of vascular smooth muscle technology in the treatment of thin endometrial infertility, and to provide a theoretical basis for the further diagnosis and treatment of thin endometrial infertility. Methods: In accordance with the inclusion and exclusion criteria, 2015.01-2020.01 selected thin endometrial infertility patients undergoing freeze-thaw embryo transfer at the Female Pelvic Floor Urinary Reconstructive Center in Dalian Municipal Women and Children’s Medical Center were selected according to different treatment methods. For the two groups, pure estrogen therapy was used as the control group, and vascular smooth muscle technology combined with estrogen therapy was used as the study group. All patients' endometrial thickness and pregnancy and delivery were recorded before and after treatment. Results: 1. The endometrial thickness of the study group was significantly larger than that of the control group after treatment, the difference was statistically significant ( P <0.05); 2. 80 patients in the study group, 13 cases of successful pregnancy and delivery, 5 cases of biochemical pregnancy; the endometrial changes of the 50 patients in the control group was not obvious after treatment, none of the endometrial thicknesses reached the embryo transfer standard, and none were transplanted. Conclusion: Vascular smooth muscle technology can effectively increase the thickness of endometrium, with the aim of assisting to improve the pregnancy success rate of thin endometrial infertility through vascular smooth muscle technology.

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Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer

Abstract: G-CSF: granulocyte colony-stimulating factor; M-CSF: macrophagecolony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; FET: frozen embryo transfer; IVF: in vitro fertilization.

Cited by 38 publications

References 38 publications

Role of granulocyte colony-stimulating factor in human reproduction

Role of granulocyte colony-stimulating factor in human reproduction

Therapeutic role of granulocyte macrophage colony‐stimulating factor (GM‐CSF) in patients with persistent thin endometrium: A prospective and randomized study

Discussion on the Efficacy of Vascular Smooth Muscle Technology in the Treatment of Thin Endometrial Infertility

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