Granulocyte Colony‐stimulating Factor Suppresses Autologous Tumor Killing Activity of the Peripheral Blood Lymphocytes in the Patients with Ovarian Carcinoma

Ohta, Yoshiaki; Hayakawa, Satoshi; Karasaki‐Suzuki, Miki; Sakai, Kenji; Komine, Shihoko; Chishima, Fumihisa; Hatta, Yoshihiro; Horie, Takashi; Seo, Naohiro; Sheikh, Aleemuzzaman; Nemoto, Norimichi; Yamamoto, Tatsuo

doi:10.1111/j.1600-0897.2004.00191.x

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…IL‐12 is mainly produced by antigen presentation cells and is considered to be one of the most important cytokines for promoting Th1 reaction. As reported by us and others, a combination of IL‐2 and IL‐12 strongly enhances lymphokine‐activated killer activities 12–15 . Hence, we treated DMNC with IL‐2 and IL‐12 with/without LPS.…”

Section: Resultsmentioning

confidence: 83%

Lipopolysaccharide (LPS)-induced Interferon (IFN)-gamma Production by Decidual Mononuclear Cells (DMNC) is Interleukin (IL)-2 and IL-12 Dependent

Negishi

Izumi

Sheikh

et al. 2010

American Journal of Reproductive Immunology

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Section: Resultsmentioning

confidence: 83%

Lipopolysaccharide (LPS)-induced Interferon (IFN)-gamma Production by Decidual Mononuclear Cells (DMNC) is Interleukin (IL)-2 and IL-12 Dependent

Negishi

Izumi

Sheikh

et al. 2010

American Journal of Reproductive Immunology

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“…In conclusion, this manuscript does not exclude the use of rhG-CSF in severe neutropenic pretenn newborns (where it might be mandatory) (21), but underlines the necessity to find the right criteria to safely administer this drug, as also reported for neutropenic cancer patients (48). Further studies are therefore necessary to establish suitable guidelines.…”

Section: Discussionmentioning

confidence: 95%

Increased Levels of IGF-1 and Beta2-Microglobulin in Epithelial Lining Fluid of Preterm Newborns Developing Chronic Lung Disease: Effects of rhG-CSF

Capoluongo

Vento

Ameglio³

et al. 2006

Int J Immunopathol Pharmacol

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Insulin-like growth factor-I (IGF-I) is involved in regulating the TH-lITH-2 balance, favoring the development of the TH-2 compartment which enhances fibrosis, one of the main characteristics of Chronic Lung Disease (CLD) in premature newborns. Limited data is available concerning a possible association between early epithelial lining fluid (ELF) concentrations ofIGF-I (total and free forms), IGF-binding protein-3 (IGFBP-3), b2-microglobulin (B2M) and subsequent development of CLD in preterm neonates. If neutropenic, preterm neonates are frequently treated with recombinant human Granulocyte Colony Stimulating Factor (rhG-CSF). The objective of the study was to correlate ELF concentrations of IGF-I and B2M during the first week of life both in non-neutropenic and in rhG-CSF-treated neutropenic preterm neonates, with subsequent development in CLD. Thirty preterm neonates with Respiratory Distress Syndrome (6 with neutropenia) were studied. Eleven out of 24 non-neutropenic preterm infants (46%) and all of the six neutropenic subjects (IOOo/~) developed CLD. With the exception of first day values, there was a clear similarity in the behaviors of assayed molecules between non-neutropenic and neutropenic patients developing CLD. Non-neutropenic patients without CLD showed significantly lower values of free IGF-I and B2M both on days 1 and 3. Total IGF-I and cell counts were different only on the 3rd day. Conclusions: I) the mechanisms leading to CLD might be mediated by high levels of IGF-family molecules soon after birth 2) B2M could be a marker of increased bronchoalveolar lavage fluid cellularity with potential inflammatory properties 3) G-CSF treatment induces an increased synthesis of IGF-I moleculesby cells recruited in the lung, with possible enhancement of the fibrogenic mechanisms. Chronic lung disease (CLD) in very low birth weight infants is a major health concern facing neonatologists because of its morbidity and high mortality risk (1-2). The pathogenesis of CLD is still unclear, although several risk factors have been described (3-6). Great importance has recently been attributedto pulmonary inflammation(1-3) and several pro-inflammatory and anti-inflammatory/fibrogenic cytokines in bronchoalveolar lavage fluid (BALF) have been indicated as possible triggers of pulmonary fibrosis (1-3, 5), one of the main characteristics of CLD (I). In adult lung fibrosis, an

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“…Of interest, the requirement of IL-12 for IFN-c production by TLR stimulation has been reported [5,9]. We and others have reported indispensable roles for IL-2 and IL-12 in the stimulation of lymphokineactivated killer (LAK) cells against choriocarcinoma and autologous tumor cells [10][11][12]. Therefore, we asked whether the presence of IL-2 and IL-12 would affect TLR3 expression and subsequent TLR3-mediated NK cell activation.…”

Section: Introductionmentioning

confidence: 97%

Synergistic induction of interferon-γ by interleukin-2, interleukin-12 and poly(I:C) in a human natural killer cell line

Majima-Horiuchi

Komine‐Aizawa

Karasaki‐Suzuki

et al. 2018

Immunological Medicine

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Natural killer (NK) cells express various Toll-like receptors (TLRs). Little is known about the role of TLRs in direct NK cell activation. To clarify possible synergistic roles of cytokine and TLR signaling, human NK cell line KHYG-1 was stimulated with agonists for TLR1-9. IFN-c production was not significantly induced following stimulation with single TLR agonists. Of the nine TLR agonists tested, only poly(I:C) strongly upregulated IFN-c production by synergistic interleukin-2 (IL-2) and IL-12 stimulation. The role of TLR3 signaling was also examined. An inhibitor of Toll-IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) blocked this synergistic action. However, TLR3 expression was unchanged in the presence of IL-2 and IL-12. Our findings suggest a possible role for type 1 cytokines in NK cell IFN-c production against viral infections. ARTICLE HISTORY

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Granulocyte Colony‐stimulating Factor Suppresses Autologous Tumor Killing Activity of the Peripheral Blood Lymphocytes in the Patients with Ovarian Carcinoma

Abstract: The G-CSF appears to be a suppressor of antitumor immunity. Routine administration of G-CSF to cancer patients may not be recommended, except for febrile neutropenia.

Cited by 7 publications

References 24 publications

Lipopolysaccharide (LPS)-induced Interferon (IFN)-gamma Production by Decidual Mononuclear Cells (DMNC) is Interleukin (IL)-2 and IL-12 Dependent

Lipopolysaccharide (LPS)-induced Interferon (IFN)-gamma Production by Decidual Mononuclear Cells (DMNC) is Interleukin (IL)-2 and IL-12 Dependent

Increased Levels of IGF-1 and Beta2-Microglobulin in Epithelial Lining Fluid of Preterm Newborns Developing Chronic Lung Disease: Effects of rhG-CSF

Synergistic induction of interferon-γ by interleukin-2, interleukin-12 and poly(I:C) in a human natural killer cell line

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