Granulocyte-colony stimulating factor-producing esophageal carcinoma: serum level as a marker for monitoring the effects of treatment

Matsumoto, Gaku; Ise, Hideo; Kimura, Yoshizo; Inoue, Hirofumi; Suzuki, Naohiro; Ohtani, Haruo; Ogawa, Hitoshi; Fukushima, Kouhei; Matsuno, Seiki

doi:10.1007/pl00012058

Cited by 11 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a PubMed search, 14 case reports (13-26) and 6 cited publications (11,(27)(28)(29)(30)(31) regarding G-CSF-producing upper gastrointestinal tract cancers, including esophageal cancer (12 cases), EGJ cancer (1 case), and gastric cancer (7 cases), were retrieved from the English-language literature. Demographic and clinical characteristics for all of the described cases of such cancers, including the present case, are summarized in Table I.…”

Section: Discussionmentioning

confidence: 99%

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

et al. 2018

View full text Add to dashboard Cite

Abstract. The current study presents the case of a 72-year-old woman with a rapidly enlarged liver metastasis from esophagogastric junction (EGJ) cancer, accompanied by progressive leukocytosis (47,680/µl) and elevated serum granulocyte colony-stimulating factor (G-CSF; 779 pg/ml). The patient underwent right hemihepatectomy 26 months after a total gastrectomy. On the seventh post-operative day the patient's leukocyte count and serum G-CSF level decreased to 4,280/µl and ≤19.5 pg/ml, respectively. Histologically, the lesion was a well to moderately differentiated adenocarcinoma similar to the primary lesion. Therefore, this tumor was clinically diagnosed as a G-CSF-producing liver metastasis from EGJ cancer, although immunohistochemical staining for G-CSF was negative. A right pulmonary nodule detected simultaneously with the hepatic mass was resected four months following the hepatectomy and was diagnosed as a pulmonary metastasis. The patient's leukocyte count was normal at the time of her initial surgery for EGJ cancer, and her clinical course varied for different metastatic sites. The liver metastasis was accompanied by progressive leukocytosis and elevated serum G-CSF and demonstrated rapid tumor growth during a six-month period, whereas the non-G-CSF-producing pulmonary metastasis grew slowly during the same period. In addition 21 reported cases of G-CSF-producing upper gastrointestinal tract cancer were reviewed to elucidate the clinicopathological features of this disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

et al. 2018

View full text Add to dashboard Cite

show abstract

“…G-CSF-producing tumors of esophageal SCC are extremely rare, with only ten such cases, including ours, reported in the English literature [1][2][3][4][5][6][7][8][9] (Table 2). Age at onset ranged from 30 to 81 years (mean 63 years), and the male:female ratio was 9:1.…”

Section: Discussionmentioning

confidence: 96%

“…The number of reports of gastrointestinal tumors that produce G-CSF has recently increased, however, only nine previous cases of G-CSF-producing esophageal squamous cell carcinoma (SCC) have been reported [1][2][3][4][5][6][7][8][9]. Moreover, there have been no reports of patients with gastric metastasis from G-CSF-producing esophageal SCCs.…”

Section: Introductionmentioning

confidence: 99%

Gastric metastasis from esophageal squamous cell carcinoma producing granulocyte colony-stimulating factor: report of a case and literature review

et al. 2015

View full text Add to dashboard Cite

We report an extremely rare case of gastric metastasis from a granulocyte colony-stimulating factor (G-CSF)-producing carcinoma of the esophagus. A 63-year-old Japanese man presented with an aggressive esophageal and gastric tumor and concomitant severe leukocytosis (21,700/mm 3 ) with pyrexia. The serum level of G-CSF was markedly elevated to 253 pg/ml (normal \ 9.8 pg/ml). Histological examination of the surgical specimen showed a moderately differentiated squamous cell carcinoma (SCC) of the esophagus and stomach, with tumor cells immunohistochemically positive for G-CSF. The leukocyte count and G-CSF concentration decreased after surgery. The patient was diagnosed with G-CSFproducing esophageal SCC with gastric metastasis. This is the first case of G-CSF-producing esophageal SCC with gastric metastasis.

show abstract

“…Therefore, we diagnosed the patient with G-CSF-producing ESCC. To the best of our knowledge, G-CSF-producing ESCCs are rare, with only 12 cases reported in English literature, including this report [8][9][10][11][12][13][14][15][16][17][18]. In particular, this report is the first case of G-CSF-producing ESCC with choroidal metastasis.…”

Section: Discussionmentioning

confidence: 97%

Choroidal metastasis from granulocyte colony‐stimulating factor‐producing esophageal squamous cell carcinoma: a case report

Fukuda

Fujiwara

Mishima

et al. 2017

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Granulocyte-colony stimulating factor-producing esophageal carcinoma: serum level as a marker for monitoring the effects of treatment

Cited by 11 publications

References 20 publications

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

Gastric metastasis from esophageal squamous cell carcinoma producing granulocyte colony-stimulating factor: report of a case and literature review

Choroidal metastasis from granulocyte colony‐stimulating factor‐producing esophageal squamous cell carcinoma: a case report

Contact Info

Product

Resources

About