Granulocyte Colony–Stimulating Factor Mobilizes CD34+ Cells and Improves Survival of Patients With Acute-on-Chronic Liver Failure

Garg, Vishal; Garg, Hitendra; Khan, Arshi; Trehanpati, Nirupama; Kumar, Ashish; Sharma, Barjesh Chander; Sakhuja, Puja; Sarin, Shiv Kumar

doi:10.1053/j.gastro.2011.11.027

Cited by 342 publications

(343 citation statements)

References 36 publications

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“…Liver biopsy is an important mode of understanding and validating the results of clinical trials exploring various therapeutic options, e.g., mobilization of bone marrowderived stem cells with granulocyte colony-stimulating factor (GCSF) [57].…”

Section: Role Of Liver Histology In Aclfmentioning

confidence: 99%

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Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014

et al. 2014

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The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. Due to the rapid advancements in the knowledge and available information, a consortium of members from countries across Asia Pacific, ''APASL ACLF Research Consortium (AARC),'' was formed in 2012. A large cohort of retrospective and prospective data of ACLF patients was collated and followed up in this data base. The current ACLF definition was reassessed based on the new AARC data base. These initiatives were concluded on a 2-day meeting in February 2014 at New Delhi and led to the development of the final AARC consensus. Only those statements which were based on the evidence and were unanimously recommended were accepted. These statements were circulated again to all the experts and subsequently presented at the annual conference of the APASL at Brisbane, on March 14, 2014. The suggestions from the delegates were analyzed by the expert panel, and the modifications in the consensus were made. The final consensus and guidelines document was prepared. After detailed deliberations and data analysis, the

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Section: Role Of Liver Histology In Aclfmentioning

confidence: 99%

“…There have been promising results of the use of growth factors in such patients. Garg et al [57] have shown that granulocyte colony-stimulating factor (GCSF) can help in hepatic regeneration by mobilizing bone marrow-derived CD34 ? cells.…”

Section: Liver Transplantationmentioning

confidence: 99%

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014

et al. 2014

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“…The mechanism is thought to be mobilisation of hematopoietic stem cells to the liver leading to an increased number of CD34 positive progenitor cells stimulating the regeneration process. This was demonstrated in the study of Garg et al [12] leading to a significant survival benefit. Duan et al…”

Section: Editorialmentioning

confidence: 77%

Liver transplantation in acute-on-chronic liver failure

Williams¹

2017

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“…In a recent study, Garg et al tested the possibility that mobilization of bone marrow-derived stem cells with granulocyte colony-stimulating factor could promote hepatic regeneration. 115 Treatment with this cytokine resulted in a significantly higher survival and improvement of liver function parameters. These intriguing results await confirmation from different groups and different geographical areas.…”

Section: Cell-based Therapiesmentioning

confidence: 97%