2016
DOI: 10.1016/j.bbmt.2015.12.015
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Granulocyte Colony-Stimulating Factor–Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease

Abstract: We defined associations among immune cell subsets in granulocyte colony-stimulating factor (G-CSF)-mobilized allografts and clinical outcomes after allogeneic hematopoietic cell transplantation (alloHCT). Fresh peripheral blood stem cell (PBSC) aliquots from 238 G-CSF-mobilized allografts were extensively characterized by immunophenotype. Subset-specific transplanted cells were correlated with acute graft-versus-host disease (aGVHD), chronic GVHD (cGVHD), malignant disease relapse, nonrelapse mortality, and ov… Show more

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Cited by 20 publications
(19 citation statements)
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References 34 publications
(41 reference statements)
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“…Additionally, peripheral blood stem cell collection through G-CSF mobilization has been shown to be associated with different T-cell subsets than bone marrow grafts. Different allograft T-cell subset contents have been associated with risk of acute and chronic GVHD as well as risk of relapse 41 . It is possible that allografts with a higher dose of allo-reactive activated T-cells favor the development of CRS syndrome, while those with a higher number of regulatory T-cells are less likely to develop CRS.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, peripheral blood stem cell collection through G-CSF mobilization has been shown to be associated with different T-cell subsets than bone marrow grafts. Different allograft T-cell subset contents have been associated with risk of acute and chronic GVHD as well as risk of relapse 41 . It is possible that allografts with a higher dose of allo-reactive activated T-cells favor the development of CRS syndrome, while those with a higher number of regulatory T-cells are less likely to develop CRS.…”
Section: Discussionmentioning
confidence: 99%
“…There are only a few recent publications (11, 26, 32, 33) describing systematically variation in the levels of immune cell populations in clinical HSCT grafts. Many studies have concentrated on the effects of stem cell mobilizing regimens on immune cell levels.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast to G‐CSF, CoPP does not increase the number of T cells. This could be clinically relevant, as T cells may cause GVHD (Zhang et al , ; Vasu et al , ; MacDonald et al , ) and impair engraftment of HSC upon transplantation (Müller et al , ). Finally, transplantation of PBMC from CoPP‐treated donors resulted in a higher long‐term blood chimerism, even upon secondary transplantation.…”
Section: Discussionmentioning
confidence: 99%