Granulocyte Colony-Stimulating Factor Induces Neutrophils to Secrete Macrophage Colony-Stimulating Factor

Santiago, E; Mora, Lucy; Bautista, M.; Jj, Montesinos; Martı́nez, Ignacio; Ramos, G; Ir, Zambrano; Manrique, B; Weiss‐Steider, Benny

doi:10.1006/cyto.2001.0937

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…The capacity of neutrophils to produce large amounts of CSF1 is consistent with the neutrophil RNA profile reported by the ImmGen consortium (http://www.immgen.org). Moreover, neutrophil production of CSF1 has been noted in another context, specifically during activation of neutrophils by sodium caseinate, which is used in a mouse experimental model of peritoneal inflammation . The demonstration that neutrophils are an important source of CSF1 illustrates a mechanism through which neutrophils promote their subsequent replacement with mononuclear phagocytes during skin inflammation.…”

Section: Discussionmentioning

confidence: 99%

Nonredundant roles of keratinocyte‐derived IL‐34 and neutrophil‐derived CSF1 in Langerhans cell renewal in the steady state and during inflammation

et al. 2015

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IL-34 and colony stimulating factor 1 (CSF1) are two alternative ligands for the CSF1 receptor that play non-redundant roles in the development, survival and function of tissue macrophages and Langerhans cells (LCs). In this study, we investigated the spatio-temporal production of IL-34 and its impact on skin LCs in the developing embryo and adult mice in the steady state and during inflammation using Il34LacZ reporter mice and newly generated inducible Il34-knockout mice. We found that IL-34 is produced in the developing skin epidermis of the embryo, where it promotes the final differentiation of LC precursors. In adult life, LCs required IL-34 to continually self-renew in the steady-state. However, during UV-induced skin damage, LCs regeneration depended on neutrophils infiltrating the skin, which produced large amounts of CSF1. We conclude that LCs require IL-34 when residing in fully differentiated and anatomically intact skin epidermis, but rely on neutrophil-derived CSF1 during inflammation. Our demonstration that neutrophils are an important source of CSF1 during skin inflammation may exemplify the mechanism through which neutrophils promote their subsequent replacement with mononuclear phagocytes.

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Section: Discussionmentioning

confidence: 99%

Nonredundant roles of keratinocyte‐derived IL‐34 and neutrophil‐derived CSF1 in Langerhans cell renewal in the steady state and during inflammation

et al. 2015

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“…Li Volti et al 7 investigated the effect of HO-1 expression on cell cycle progression in endothelial cells (EC) and smooth muscle cells (SMC) and found that HO-1 regulated the cell cycle in a cell-specific manner; it increased EC but decreased the SMC cycle progression. Mayer 1 and Santiago et al 2 found that an inverse relationship exists between circulating bilirubin concentrations and risk of CAD, but studies on the relationship between HO-1 and CHD were rarely conducted. While the majority of evidence supports a cytoprotective role for HO-1, this is not a universal finding.…”

Section: Fpo Only 4 Colormentioning

confidence: 99%

“…These products have important physiologic effects: bilirubin is a potent antioxidant that can act against ischemia/reperfusion injury; there is a negative correlation between the content of HO-1 and the incidence of coronary heart disease (CHD). 1,2 Carbon monoxide was previously regarded as a poisonous gas; however, recent studies have shown carbon monoxide to be a factor acting as a potent vasodilator within its physiologic concentration; CO activates soluble guanylate cyclase and elevates the level of cyclic guanosine monophosphate (cGMP) in target tissues, which dilates blood vessels, and also does this by directly activating potassium channels in vascular smooth muscle cells. In addition, CO inhibits platelet aggregation and proliferation of vascular smooth muscle cells, inhibits apoptosis, and stimulates angiogenesis for regulation of cardiovascular function.…”

Section: Introductionmentioning

confidence: 99%

Study on changes of heme oxygenase‐1 expression in patients with coronary heart disease

Chen

Wang

2005

Clinical Cardiology

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SummaryBackground: Heme oxygenase (HO) is a rate-limiting enzyme of endogenetic carbon monoxide (CO) that degrades heme into carbon monoxide, bilirubin, and iron. These products have important physiologic effects: bilirubin is a potent antioxidant that can act against ischemia/reperfusion injury; there is a negative correlation between the content of HO-1 and the incidence of coronary heart disease (CHD).Hypothesis: This study was undertaken to investigate the changes of HO-1 in patients with CHD.Methods: Thirty-five patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP, diagnosed by coronary angiography), and 30 patients with stable angina pectoris (AP, diagnosed by coronary angiography) were selected for the study; another 30 patients with normal coronary artery (diagnosed by coronary angiography) were selected as controls. The levels of HO-1 protein expression in monocyte and lymphocyte in the subjects were tested by immunohistochemistry and western blot. Computer picture analyzing systems were also used to measure the levels of HO-1 protein expression.Results: Heme oxygenase-1 protein is located in cell plasma. The levels of HO-1 protein expression in patients with CHD were significantly higher than in those without CHD (p < 0.01). There were significant differences of HO-1 expression among the three groups of patients with CHD. The group

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“…Given that granulocyte-band neutrophils can secrete M-CSF (Santiago et al 2001) and that intraperitoneal CasNa inoculation induces strong granulocyte accumulation Sachs 1983, 1985), in this work we evaluated whether M-CSF was secreted from granulocytes treated with CasNa.…”

Section: Introductionmentioning

confidence: 99%

Sodium caseinate induces secretion of macrophage colony-stimulating factor from neutrophils

Santiago‐Osorio¹,

Mora²,

Bautista³

et al. 2010

Immunobiology

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Granulocyte Colony-Stimulating Factor Induces Neutrophils to Secrete Macrophage Colony-Stimulating Factor

Cited by 7 publications

References 19 publications

Nonredundant roles of keratinocyte‐derived IL‐34 and neutrophil‐derived CSF1 in Langerhans cell renewal in the steady state and during inflammation

Nonredundant roles of keratinocyte‐derived IL‐34 and neutrophil‐derived CSF1 in Langerhans cell renewal in the steady state and during inflammation

Study on changes of heme oxygenase‐1 expression in patients with coronary heart disease

Sodium caseinate induces secretion of macrophage colony-stimulating factor from neutrophils

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