Granulocyte colony‐stimulating factor has a sex‐dependent positive effect in the maternal immune activation‐induced autism model

Durankuş, Ferit; Albayrak, Yakup; Erdoğan, Fırat; Albayrak, Neslihan; Erdoğan, Mümin Alper; Erbaş, Oytun

doi:10.1002/jdn.10221

Cited by 9 publications

(7 citation statements)

References 50 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings support the relationship between vitamin D and autism inflammation ( 32 ). Durankus demonstrated the beneficial effect of granulocyte colony-stimulating factor (G-CSF) in improving the core symptoms of ASD without serious side effects ( 33 ). Alizadeh reported that miRNAs might regulate targets of ASD-related pathways, such as neuroactive ligand-receptor interactions, 5-hydroxytryptaminergic synapses, calcium signaling, cAMP signaling, and PI3K-Akt signaling pathways ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of genomic and immune infiltration patterns in autism spectrum disorder

Wei¹,

Guo²,

Wu³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background: Autism spectrum disorder (ASD) is a specific type of pervasive developmental disorder, and most studies suggest that the onset of autism may be related to genetic and immune factors. The etiology of autism and the underlying molecular events need to be further addressed. Methods:The ASD-related dataset GSE18123 was downloaded from the Gene Expression Omnibus (GEO) database. Gene set enrichment analysis (GSEA) was used to screen for Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that may be associated with autism. The top 5,000 genes with an absolute median difference were obtained, and a co-expression network was constructed using weighted correlation network analysis (WGCNA). In addition, GO and KEGG enrichment analyses were performed for genes in the modules most closely related to ASD. Hub genes were found in the significant modules, and the expression values and receiver operating characteristic (ROC) curves of the hub genes were analyzed and validated. Immune cell infiltration in ASD was calculated using the CIBERSORT algorithm, and the relationship between hub genes and immune cells was analyzed. Finally, GSEA was used to explore the potential pathways of hub genes affecting ASD. Results:The 5,000 DEGs were divided into eight significant modules by WGCNA. The green module was most significantly associated with ASD, and two hub genes [fatty acid-binding protein 2 (FABP2) and Janus kinase 2 (JAK2)] were found. Immune cell infiltration showed that resting dendritic cells and monocytes differed significantly in ASD and healthy individuals. FABP2 was significantly associated with memory B cells and CD8 T cells. JAK2 was significantly associated with monocytes, CD4 activated memory T cells, CD4 resting memory T cells, activated dendritic cells, gamma delta T cells, regulatory T cells (Tregs), CD8 T cells, and naïve CD4 T cells. FABP2 and JAK2 were found to affect multiple pathways of immunity.Conclusions: FABP2 and JAK2 may influence the immune microenvironment of ASD by regulating immune cells and immune-related pathways and are candidate molecular markers for the development of ASD.

show abstract

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of genomic and immune infiltration patterns in autism spectrum disorder

Wei¹,

Guo²,

Wu³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…The histopathological examinations were performed according to previous descriptions. 32 GFAP immunohistochemistry was performed by primary antibodies against GFAP (Abcam, Inc., Mass, USA; 1/1000) for 24 hours. Olympus BX51 microscope was used for obtaining the histopathological images.…”

Section: Methodsmentioning

confidence: 99%

Torasemide Improves the Propionic Acid-Induced Autism in Rats: A Histopathological and Imaging Study

Doğan¹,

Albayrak²,

Erbas³

2023

ALPHA PSYCHIATRY

View full text Add to dashboard Cite

Objective: Autism spectrum disorder is a neurodevelopmental disease in which impaired social behaviors, impaired sociality, and restricted and repetitive behaviors are seen. Bumetanide is a loop diuretic that inhibits Na + –K + –2Cl − cotransporter 1 and it is currently used in clinical phase studies in patients with autism spectrum disorder. In present research, it is purposed to demonstrate the beneficial effects of torasemide which is another Na + –K + –2Cl − cotransporter 1 inhibitor on an experimental autism model induced with propionic acid by providing imaging and brain tissue investigations. Methods: Male Wistar rats were used in the present study (n = 30). Propionic acid of 250 mg/kg/day was administrated intraperitoneally in rats to induce autism for 5 days. Three groups were created for present study as follows: group 1, normal control (n = 10); group 2, propionic acid and saline given group (n = 10); group 3, propionic acid + tora-semide-administrated group (n = 10). Results: Torasemide group scored higher on behavioral tests compared to saline group. The brain levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-2, interleukin-17, and Nuclear Factor kappa B (NF-κB), Glial fibrillary acidic protein (GFAP) were remarkably higher in propionic acid + saline group. In histopathology assessments, torasemide group had higher neuronal count of Cornu Ammonis 1, neuronal count of Cornu Ammonis 2 in hippocampus, and Purkinje cells in cerebellum. GFAP immunostaining index (Cornu Ammonis 1) and cerebellum were lower in torasemide group. Magnetic resonance spectroscopy revealed that mean lactate value was higher in propionic acid + saline group compared to torasemide group. Conclusion: Our experimental results showed that torasemide might enhance gamma-aminobutyric acid activity. Torasemide can be considered another promising Na + –K + –2Cl − cotransporter 1 inhibitor in the treatment of autism with a longer half-life and less side effects after further studies.

show abstract

“…Recent research has demonstrated the neuroprotective impact of G-CSF treatment, which is due to its high antioxidant, anti-inflammatory, and antiapoptotic properties [10,11]. In a number of ischemic rodent models, G-CSF has been demonstrated to provide long-term neuroprotection by encouraging somatic growth and improving sensorimotor and neurocognitive skills [70,71].…”

Section: Neuroprotective Properties Of Granulocyte Colony-stimulating...mentioning

confidence: 99%

“…In a number of ischemic rodent models, G-CSF has been demonstrated to provide long-term neuroprotection by encouraging somatic growth and improving sensorimotor and neurocognitive skills [70,71]. The neuro-regenerative and neuroprotective properties of G-CSF have also been demonstrated in preclinical studies in a number of neurodevelopmental disorders, including autism, spinal cord injury, cerebral ischemia, PD, and AD [5,10,[72][73][74]. To investigate the possibility of using G-CSF for AD treatment, two different Aβ protein aggregate-induced AD mice models were used.…”

Section: Neuroprotective Properties Of Granulocyte Colony-stimulating...mentioning

confidence: 99%

“…This prompted researchers to investigate alternative therapeutic applications, such as peptides as neuroprotective agents [1][2][3][4][5]. Notably, several peptides have been applied in clinical settings, including erythropoietin (EPO), glucagon-like peptide-1 (GLP-1), granulocyte colony-stimulating factor (G-CSF), and oxytocin (OXT) [6][7][8][9][10][11][12]. Figure 1 shows the synergistic neuroprotective effects of G-CSF, GLP-1, and EPO.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroprotective Properties of Peptides

Erbaş¹,

Altuntaş²,

Nesil³

et al. 2023

Rare Neurodegenerative Disorders - New Insights [Working Title]

View full text Add to dashboard Cite

The development of a treatment strategy for neurodegenerative disorders is a serious issue for the healthcare world and a crucial subject of discussion. In the past two decades, a lot of focus has been placed on identifying the pathophysiological processes involved in neuronal death linked to neurodegenerative disorders and developing a variety of treatment options for neuroprotection. Numerous research teams have studied the use of peptides as neuroprotective treatments for different types of neurodegenerative disorders for a long time. The review aims to provide details about the roles of erythropoietin (EPO), glucagon-like peptide-1 (GLP-1), granulocyte colony-stimulating factor (G-CSF), and oxytocin (OXT) in neurodegenerative disorders as well as what cellular and molecular mechanisms they trigger to elicit the neuroprotective action, with a focus on neurodegenerative disorders.

show abstract

Granulocyte colony‐stimulating factor has a sex‐dependent positive effect in the maternal immune activation‐induced autism model

Cited by 9 publications

References 50 publications

Bioinformatics analysis of genomic and immune infiltration patterns in autism spectrum disorder

Bioinformatics analysis of genomic and immune infiltration patterns in autism spectrum disorder

Torasemide Improves the Propionic Acid-Induced Autism in Rats: A Histopathological and Imaging Study

Neuroprotective Properties of Peptides

Contact Info

Product

Resources

About