Granulocyte colony stimulating factor (GCSF) protected in ovarian tissues against ischemia-reperfusion injury

Aktaş, Ayfer; Aşır, Fırat; Başaran, Süreyya Özdemir; Kaplan, Özge; Ermiş, Işılay Sezen; Deveci, Engin

doi:10.22270/jddt.v12i4.5538

Cited by 8 publications

(6 citation statements)

References 12 publications

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“…Ovarian ischemia reperfusion causes many pathologies in ovarian tissues, as well as remote organs such fallopian tubes, uterine and cervix. Aktaş et al studied ovarian IR and found intense fibrosis, vascular dilatation and congestion, stromal inflammation in ovarian tissues after IR 12 . Peker et al investigated IR injury in ovarian tissues and revealed that IR caused edema, inflammation, congestion, degenerated follicles, and cells with pyknotic nuclei 13 .…”

Section: Discussionmentioning

confidence: 99%

E-cadherin and NF-κB expression in the vagina after ovarian ischemia and reperfusion

Yurci,

Zaman,

Sarı

et al. 2024

Acta Cir. Bras.

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Purpose: To investigate inflammation and cell adhesion molecules in the vagina after ovarian ischemia-reperfusion (IR) injury. Methods: 20 Wistar albino female rats were divided into two groups: control, and IR groups. In IR group, blood flow was restricted for 2 hours for ovarian ischemia. Then, tissues were re-blood 2 hours for reperfusion. Vagina tissues were excised and processed for histopathological analysis. Histopathological and biochemical follow-ups were performed. Results: Both malondialdehyde and myeloperoxidase values were increased in IR group compared to control group. Glutathione content was decreased in IR group compared to control group. Epithelial degeneration, inflammation, dilatation, and nuclear factor-κB (NF-κB) expression were increased in IR group compared to control group. E-cadherin expression was significantly decreased in IR group. In the IR group, E-cadherin showed a positive reaction in adenomas, gland-like cryptic structures, cellular junctions with clustered inflammatory cells. In the IR group, NF-κB expression was increased in basement membrane, inflammatory cells, in blood vessels. Conclusions: Ovarian ischemia caused degeneration of epithelial cells in the vaginal region and disruptions in the cell junction complex, which leads to activation of E-cadherin and NF-κB signaling pathway and alterations in reproductive and embryonal development in the vaginal region.

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Section: Discussionmentioning

confidence: 99%

E-cadherin and NF-κB expression in the vagina after ovarian ischemia and reperfusion

Yurci,

Zaman,

Sarı

et al. 2024

Acta Cir. Bras.

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“…The harmful effects of free oxygen radicals (ROS) formed as a result of ischemia increase with the reperfusion into the tissues during the reperfusion phase. 18 . The brain is one of the most important organs to be affected by ischemia reperfusion.…”

Section: Discussionmentioning

confidence: 99%

Effect of Biochanin-A on The Cerebellum in Cerebral Ischemia Reperfusion Injury

AVINCA,

KAPLAN,

AŞIR

2024

J Cukurova Anesth Surg

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Objective: To examine the protective effect of Biochanin A (BCA) on the cerebellum in cerebral ischemia reperfusion injury. Material and Metodhs: 24 Wistar albino female rats were divided into 3 groups. Control, Ischemia reperfusion (IR), IR +BCA (20 mg/kg intraperitoneal) group. A micro bulldog clamp was placed on the left common carotid artery of the rats and cerebral ischemia was applied for 2 hours. After cerebral ischemia, the clamp was removed and reperfusion was performed for 24 hours. After 7 days, all rats were decapitated and the protective effects of Biochanin A on the cerebellum were evaluated by immunohistochemically analyses. Results: In the IR group; S100 expression was also observed positive in neurons and neuroglia in the pia mater, molecular layer, Purkinje cells in the ganglionic layer and granule cells in the granular layer, and neuroglia in the white matter. In the IR+ Biochanin A group, it was observed that the immune activity in the granule cells and Purkinje cells in the granular layer was reduced compared to the IR group. Conclusion: We suggest that Biochanin A treatment has a potential therapeutic role in alleviating inflammation in the cerebellum after cerebral ischemia reperfusion.

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“…Both ischemia and reperfusion can cause damage to tissues separately. The harmful effects of free oxygen radicals (ROS) formed as a result of ischemia are increased by reperfusion into the tissues 15 . Intestinal ischemia, whose mortality varies between 60-80%, is one of the most important abdominal emergencies 16 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Gallic Acid on Distant Organ Stomach in Intestinal Ischemia Reperfusion Injury

Başaran

Kaplan

Aşır

2023

J. Drug Delivery Ther.

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Aim: To examine the effects of gallic acid (GA) in the stomach in rats undergoing intestinal ischemia/reperfusion (IR) with Beclin -1 immunostaining. Material-Metod: 24 male Wistar albino rats were divided into control, IR and IR+GA groups. For the IR protocol, 60 minutes of ischemia and reperfusion were applied. The small intestines of the rats in the control group were removed by laparotomy and the abdomen was closed without applying anything else. Ischemia and reperfusion was applied to the superior mesenteric artery (SMA) for 60 minutes with a clamp in rats in the IR group. The blood flow was stopped with a clamp on the SMA of the rats in the IR+GA group and ischemia was applied for 60 minutes. 50 mg/kg gallic acid was given intraperitoneally to the animals, 60 minutes of reperfusion was performed, and the abdomen was closed. The stomach tissues were placed in paraffin blocks after routine histological follow-ups. Five micrometer-thick sections were taken from the paraffin blocks and stained with Hematoxylin-eosin and Beclin-1 immunostaining. Results: In the IR group, degeneration of gastric folds, apoptosis of epithelial cells and degeneration of lamina muscularis were observed. In the IR + GA group, gastric folds improved, but cell infiltration in the lamina propria and degeneration in the muscular layer were observed. Beclin-1 expression was positively observed in the surface epithelial cells and gastric glands in the control group. In the IR group, it was observed that the gastric folds were positive on the surface cells and negative in the submucosa, while in the IR + GA group, it was intensely expressed in the gastric epithelium and gastric glands. Conclusion: By increasing the expression of beclin-1, GA treatment induced autophagy in gastric mucosal cells, triggered the destruction of damaged cells and provided restoration of the mucosal layer. Keywords: Beclin-1, gallic acid, apoptosis

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Granulocyte colony stimulating factor (GCSF) protected in ovarian tissues against ischemia-reperfusion injury

Cited by 8 publications

References 12 publications

E-cadherin and NF-κB expression in the vagina after ovarian ischemia and reperfusion

E-cadherin and NF-κB expression in the vagina after ovarian ischemia and reperfusion

Effect of Biochanin-A on The Cerebellum in Cerebral Ischemia Reperfusion Injury

Effect of Gallic Acid on Distant Organ Stomach in Intestinal Ischemia Reperfusion Injury

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