Granulocyte collection using a novel apheresis system eases the procedure and provides concentrates of high quality

Leitner, Gerda; Kolovratova, Vera; Horvath, Michaela; Worel, Nina

doi:10.1111/trf.12928

Cited by 8 publications

(5 citation statements)

References 18 publications

(26 reference statements)

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“…The CD34-positive cell collection efficiency of Spectra Optia was found to be comparable to or better than that of COBE Spectra [24][25][26][27]. GC efficiency has also been compared between COBE Spectra and Spectra Optia systems [7,28]. However, in these studies HES was used.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of two apheresis systems for granulocyte collection without hydroxyethyl starch

Hosoi,

Nakajima,

Tsujimoto

et al. 2023

Vox Sanguinis

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Background and ObjectivesGranulocyte transfusion (GTX) is a treatment option for severe infections in patients with neutropenia. In previous studies, hydroxyethyl starch (HES) was used to enhance red blood cell sedimentation for granulocyte collection (GC). However, there are safety concerns about HES, and HES is not readily available in some countries. Therefore, we compared the granulocyte counts and GC efficiency achieved by two apheresis systems without HES.Materials and MethodsAll consecutive GC procedures performed between July 2011 and March 2018 at our hospital were analysed. COBE Spectra was used until 5 February 2016, and Spectra Optia was used afterwards. HES was not used.ResultsTwenty‐six GC procedures were performed, including 18 performed using COBE Spectra and 8 using Spectra Optia. When Spectra Optia was used, >1 × 1010 neutrophils were collected from seven of the eight (88%) procedures. Although there was no significant difference in the granulocyte yield between COBE Spectra‐based and Spectra Optia‐based GC procedures, the collection efficiency of Spectra Optia was significantly higher than that of COBE Spectra (p = 0.021). Furthermore, the granulocyte yields of Spectra Optia‐based GC tended to be more strongly correlated with the peripheral blood neutrophil count on the day of apheresis than those of COBE Spectra‐based GC.ConclusionOur results suggest that Spectra Optia achieves greater GC efficiency than COBE Spectra, even without HES. GTX may be a therapeutic option for severe neutropenia, even in places where HES is not available.

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Section: Discussionmentioning

confidence: 99%

“…In addition, HES is not available in some countries, and it is not approved as a drug in Japan. A cell separator system, Spectra Optia, which is the successor of COBE Spectra, has been reported to increase the yield of granulocyte collection (GC) [6,7]. In these studies, HES was used during GC.…”

Section: Introductionmentioning

confidence: 99%

Comparison of two apheresis systems for granulocyte collection without hydroxyethyl starch

Hosoi,

Nakajima,

Tsujimoto

et al. 2023

Vox Sanguinis

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“…The target process volume of whole blood was set at 7 L; however, the collections were completed when 500 ml of HES was consumed in the HES group. The PMN collection program of Optia has an automated interface monitoring system placed in the chamber, which performs real‐time interface monitoring, interpretation, and adjustment for flexible procedural control 18 . However, collection preference needs to be optimised in the non‐HES group because the clear interface is not formed in the absence of HES.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, several studies have shown that a novel cell separator (Spectra Optia) could provide greater granulocyte yields than an earlier system (COBE Spectra), which was used in our previous study 18,19 . We hypothesized that the use of a newer device would spare the need for using HES.…”

Section: Introductionmentioning

confidence: 93%

Impact of the use of hydroxyethyl starch in granulocyte apheresis using Spectra Optia

Yoshihara

Ikemoto

Onomoto

et al. 2021

Transfusion Medicine

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Objectives To determine the impact of the use of hydroxyethyl starch (HES) in granulocyte apheresis using Spectra Optia. Background Granulocyte transfusion (GT) is a therapeutic option for neutropenic patients with severe bacterial or fungal infections. Recent studies in emergency medicine have shown the potential risk of using HES, which is routinely used in granulocyte apheresis to increase yield by sedimenting red blood cells. We hypothesized that the use of a newer device (Spectra Optia) would spare the need for HES. Methods We retrospectively compared granulocyte apheresis with HES (HES group, n = 89) and without HES (non‐HES group, n = 36) using Spectra Optia. Results The granulocyte yield was significantly higher in the HES group (7.3 × 1010 vs. 2.0 × 10, p < 0.01) and was attributed to the difference in collection efficiency (36% vs. 7.7%, p < 0.01). The absolute neutrophil count on the following morning of GT was significantly higher in the HES group than in the non‐HES group (2460/μl vs. 505/μl, p < 0.01). There were no significant differences in the occurrence of adverse events between the HES and non‐HES groups. The renal function was unchanged in both groups after apheresis. Conclusions We demonstrated that the advantage of using HES remained unchanged in granulocyte apheresis using Spectra Optia.

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“…The Optia device has also been used to collect granulocytes from healthy blood donors and family donors mobilized with prednisolone or G-CSF. [ 29 ]. One study showed that the Optia ® device is not inferior to the COBE Spectra forerunner and produces high-quality granulocyte concentrates with greater absolute neutrophil yields.…”

Section: Granulocyte Collection and Storagementioning

confidence: 99%

Granulocyte transfusions in children and adults with hematological malignancies: benefits and controversies

et al. 2015

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Bacterial and fungal infections continue to pose a major clinical challenge in patients with prolonged severe neutropenia after chemotherapy or hematopoietic stem cell transplantation (HSCT). With the advent of granulocyte colony-stimulating factor (G-CSF) to mobilize neutrophils in healthy donors, granulocyte transfusions have been broadly used to prevent and/or treat life-threatening infections in patients with severe febrile neutropenia and/or neutrophil dysfunction. Although the results of randomized controlled trials are inconclusive, there are suggestions from pilot and retrospective studies that granulocyte transfusions may benefit selected categories of patients. We will critically appraise the evidence related to the use of therapeutic granulocyte transfusions in children and adults, highlighting current controversies in the field and discussing complementary approaches to modulate phagocyte function in the host.

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Granulocyte collection using a novel apheresis system eases the procedure and provides concentrates of high quality

Abstract: GC with the fully automated Optia device is safe for donors, is not inferior to its forerunner Cobe Spectra, produces GTX of a high quality, and requires less manpower than the Cobe Spectra.

Cited by 8 publications

References 18 publications

Comparison of two apheresis systems for granulocyte collection without hydroxyethyl starch

Comparison of two apheresis systems for granulocyte collection without hydroxyethyl starch

Impact of the use of hydroxyethyl starch in granulocyte apheresis using Spectra Optia

Granulocyte transfusions in children and adults with hematological malignancies: benefits and controversies

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