Granulocyte and monocyte adsorption apheresis for Behçet's disease in a pregnant woman

Higashi, Yuko; Shimokawa, Mitsuyoshi; Kawai, Kazuhiro; Kanekura, Takuro

doi:10.1111/1346-8138.12296

Cited by 10 publications

(9 citation statements)

References 16 publications

(34 reference statements)

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“…GCAP was initially approved for the treatment of UC . Later, it was shown to be effective on various skin conditions, such as generalised pustular psoriasis, psoriatic arthritis, systemic lupus erythematosus skin rash, Behcet's disease and PG .…”

Section: Discussionmentioning

confidence: 99%

“…GCAP was initially approved for the treatment of UC (5-7). Later, it was shown to be effective on various skin conditions, such as generalised pustular psoriasis, psoriatic arthritis, systemic lupus erythematosus skin rash, Behcet's disease and PG (8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The efficacy of GCAP has been reported in some patients with both PG and an inflammatory bowel disease (either UC or CD) (13,18,19), but only seven patients with PG have been successfully treated with this apheretic technique (14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

“…It has been initially approved for the treatment of UC because of activated granulocytes . GCAP has also been reported to be effective for other disorders attributable to activated neutrophils, including PG . Here, we report a case of refractory PG successfully treated by GCAP.…”

Section: Introductionmentioning

confidence: 90%

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Successful treatment of pyoderma gangrenosum with granulocyte and monocyte adsorption apheresis

Russo

Miotto

Colpo

et al. 2016

International Wound Journal

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Pyoderma gangrenosum is a neutrophilic dermatosis clinically characterised by the presence of painful skin ulcerations with erythematous and undetermined borders and histologically by the presence of neutrophilic infiltrates in the dermis. Granulocyte and monocyte adsorption apheresis, also called granulocytapheresis, is a therapeutic strategy for extracorporeal immunomodulation that selectively removes activated granulocytes and monocytes/macrophages from the peripheral blood. Here, we report a case of a 73-year-old patient affected by a severe form of pyoderma gangrenosum presenting with multiple painful ulcers and pustules on his trunk and extremities. The disease was resistant to high doses of methylprednisolone and methotrexate and successfully treated by granulocyte and monocyte adsorption apheresis. To the best of our knowledge, this is the first report on the efficacy of granulocyte and monocyte adsorption apheresis in pyoderma gangrenosum in Europe.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Successful treatment of pyoderma gangrenosum with granulocyte and monocyte adsorption apheresis

Russo

Miotto

Colpo

et al. 2016

International Wound Journal

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“…In pregnant women, these systemic agents raise fetal risks such as teratogenicity, stillbirth and spontaneous abortion ( 68 ). GMA could be a valid treatment option in BD, since neutrophils are involved in its etiopathogenesis, as shown in Table IV ( 28 , 71 , 72 ). In their case series, Sakanoue et al ( 28 ) performed GMA five times, once a week, for the majority of patients.…”

Section: Application Of Gma In Neutrophilic Dermatosesmentioning

confidence: 99%

Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)

2022

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Adsorptive granulocyte and monocyte apheresis (GMA) is an extracorporeal treatment that selectively removes activated myeloid lineage leukocytes from peripheral blood. This technique consists of a column with cellulose acetate beads as absorptive leukocytapheresis carriers, and was initially used to treat ulcerative colitis. A literature search was conducted to extract recently published studies about the clinical efficacy of GMA in patients with different skin disorders, reporting information on demographics, clinical symptoms, treatment and clinical course. Dermatological diseases, in which GMA has been performed, include generalized pustular psoriasis, pyoderma gangrenosum, palmoplantar pustular psoriasis, Behcet's disease, Sweet's syndrome, adult-onset Still's disease, impetigo herpetiformis, reactive arthritis, acne and hidradenitis suppurativa syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus. In most patients, GMA was started after the failure of conventional therapeutic options and it was helpful in the majority of cases. Based on the information summarized, GMA could be considered a valid non-pharmacological treatment option for patients with several dermatological conditions, which are difficult to treat with other pharmacological preparations.

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“…Very little is known about the influence of BD and pregnancy to date. In few anecdotal case reports and retrospective small sample studies, both remissions and flares during pregnancy have been reported, and the effect of the disease on pregnancy remained unclear [1][2][3][4][13][14][15][16][17][18][19][20][21][22]. Based on previous studies, it can be concluded that disease activity usually regresses during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Behçet’s Disease and Pregnancy

Kurmuş¹,

Koç²

2020

Different Aspects of Behçet's Disease

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Behçet's disease (BD) is a rare, chronic, multisystemic, vasculitic disease of unknown etiology. BD is characterized by recurrent oral and genital ulcers and ocular inflammation. This systemic vasculitis may also involve the joints, skin, vascular, gastrointestinal, urogenital, and central nervous system and is associated with hypercoagulability. Disease onset is commonly around the third decade of life and has a higher prevalence along the ancient "silk route." Because the disease is often diagnosed in women of childbearing age, disease activity during pregnancy and any adverse effect on obstetric and neonatal outcomes deserve special attention. Previous retrospective studies have demonstrated that BD activity usually regresses in pregnancy because of the immunomodulatory effects of both estrogen and progesterone. Furthermore, previous reports from different countries indicate that the disease course of BD during pregnancy may vary from patient to patient and even during different pregnancies in the same woman. In this chapter, we emphasize the course of the BD and pregnancy outcomes.

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Granulocyte and monocyte adsorption apheresis for Behçet's disease in a pregnant woman

Abstract: We present a 39-year-old pregnant woman with Behçet's disease who was treated successfully with granulocyte and monocyte adsorption apheresis (GMA). There were no complications or adverse effects during her pregnancy and delivery. The neonate manifested no abnormalities.

Cited by 10 publications

References 16 publications

Successful treatment of pyoderma gangrenosum with granulocyte and monocyte adsorption apheresis

Successful treatment of pyoderma gangrenosum with granulocyte and monocyte adsorption apheresis

Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)

Behçet’s Disease and Pregnancy

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