Granulibacter bethesdensis isolated in a child patient with chronic granulomatous disease

RecurrentGranulibacter bethesdensisInfections and Chronic Granulomatous Disease

“…In contrast to most other CGD pathogens, most disseminated G. bethesdensis infections were chronic but not fatal. Although none of the 5 patients reported here died from their G. bethesdensis infections, a child from Spain died from infection with a G. bethesdensis isolate that was slightly different in its 16S rDNA sequence from the reference strain ( 10 ). Similar to our experience with humans, infection with G. bethesdensis in mice with CGD leads to a chronic persistent infection with a paucity of symptoms ( 7 ).…”

“…This finding indicated that these isolates are all appropriately designated G. bethesdensis sensu stricto. The isolate reported by Lopez et al ( 10 ) from Spain showed only a 99.7% match for the 16S rDNA sequence, which suggested regional variability or another Granulibacter sp.…”

“…The recurrent infections observed in patients with CGD, even when caused by the same species of organism, are the result of reinfection rather than relapse ( 3 , 6 ). Granulibacter bethesdensis is a recently described gram-negative bacterium in the family Acetobacteraceae ; it has been isolated from 6 patients with CGD from North and Central America and Spain ( 7 – 10 ). The initial case was in an adult who had prolonged fever, necrotizing lymphadenitis, and multiple disease recurrences culminating in cure 2 years after seeking treatment.…”

Fulminant Sepsis Due to Granulibacter bethesdensis in a 4-Year-Old Boy With X-Linked Chronic Granulomatous Disease

“…2 G. bethesdensis has since been described as having in-vitro resistance to multiple antibiotics, including quinolones, colistin and beta-lactams. 3 This bacterium is also able to resist and even multiply in oxygen-dependent and oxygen-independent systems inside the lysosomes of human macrophages despite their acidic environment. 4 …”

“…His clinical course deteriorated over several weeks until he developed multiple organ failure and died. 3 The second fatal case was a 16-year-old boy from Portugal, who presented fever, cough and altered mental status. He was found to have bilateral pneumonia and multiple intraparenchymal brain abscesses.…”