“…In contrast, the corresponding chymase locus in mice has undergone extensive expansion, and encompasses several different MC chymase genes, including one α-chymase (mMCP-5) but also several β-chymases: MC protease (Mcpt)1, Mcpt2, Mcpt4, Mcpt9 , and Mcpt10 (Hellman & Thorpe, 2014; Pejler et al, 2007) (the corresponding proteins are denoted mMCP-1, -2, -4, -5, -9, and -10, respectively). Based on amino acid sequence similarities, mMCP-5 may be regarded as the homologue to human chymase, which would suggest that Mcpt5 −/− animals might represent the most relevant model for studies of human chymase function.…”