Granular Data: A Rare Submucosal Tumor of the Colon—Case Report and Review of the Literature

Pagano, Nico; Impellizzeri, Giovanna; Simone, Massimo Pierluigi Di; Rottoli, Matteo; Pirini, Maria Giulia; Lauro, Augusto; Pallio, Socrate; Poggioli, Gilberto

doi:10.1007/s10620-020-06753-x

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…The colon and rectum serve as uncommon locations, with an estimated presence in merely up to 8.5% of instances. [1][2][3][4] The histopathological examination of GCTs reveals nonencapsulated clusters of spindle-shaped cells characterized by dense eosinophilic granular cytoplasm, from which their nomenclature originates. Research has unveiled these cytoplasmic granules to be lysosomes, akin to those found in Schwann cells that have engulfed myelin.…”

Section: Discussionmentioning

confidence: 99%

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Granular Cell Tumor of the Anal Canal: Case Report and Literature Review

Prats,

P.,

et al. 2024

Journal of Coloproctology

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Granular cell tumors (GCTs) are rare benign neoplasms that can occur anywhere in the body but are most commonly found in the head and neck region. These tumors are often asymptomatic and are incidentally discovered during routine rectal examination. In some cases, symptoms may include bleeding, pain, and a palpable mass. Imaging studies such as colonoscopy, ultrasound, magnetic resonance imaging (MRI), or computed tomography can be used to characterize and measure the tumor. Treatment typically involves local resection, with or without adjuvant radiotherapy, depending on the size, location, and pathological characteristics of the tumor. The prognosis for GCTs of the anal canal is generally good, with few cases of recurrence or metastasis reported, but long-term follow-up is recommended due to the potential for late recurrence or malignant transformation. The present study reports a 39-year-old female patient who presented with anal itching associated with protrusion of a perianal mass and who underwent treatment between November 2022 and December 2023. The MRI scan revealed a nodular image in its caudal aspect with involvement of the internal sphincter between 12 and 5 o'clock, which was successfully resected. Histopathology was compatible with GCT, and the patient had a satisfactory recovery and was discharged. In conclusion, GCTs of the anal canal are rare and extremely unusual tumors that can be difficult to diagnose and manage, requiring a multidisciplinary approach for optimal management.

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Section: Discussionmentioning

confidence: 99%

“…The colon and rectum serve as uncommon locations, with an estimated presence in merely up to 8.5% of instances. 1 2 3 4…”

Section: Discussionmentioning

confidence: 99%

Granular Cell Tumor of the Anal Canal: Case Report and Literature Review

Prats,

P.,

et al. 2024

Journal of Coloproctology

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“…Although their histological behavior is usually benign, 1-2% are malignant, and a larger size and growing rate can be malignancy predictors. They can occasionally grow during follow-up and show an invasion into the muscularis propria, or be associated with dysphagia, and, in these cases, an endoscopic resection can be considered [49,50].…”

Section: Esophageal Subepithelial Lesionsmentioning

confidence: 99%

Diagnostic Endoscopic Ultrasound (EUS) of the Luminal Gastrointestinal Tract

Impellizzeri,

Donato,

De Angelis

et al. 2024

Diagnostics

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The purpose of this review is to focus on the diagnostic endoscopic ultrasound of the gastrointestinal tract. In the last decades, EUS has gained a central role in the staging of epithelial and sub-epithelial lesions of the gastrointestinal tract. With the evolution of imaging, the position of EUS in the diagnostic work-up and the staging flow-chart has continuously changed with two extreme positions: some gastroenterologists think that EUS is absolutely indispensable, and some think it is utterly useless. The truth is, as always, somewhere in between the two extremes. Analyzing the most up-to-date and strong evidence, we will try to give EUS the correct position in our daily practice.

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Affinity of Colonic Granular Cell Tumor Within the Right Colon: Case Report and Review of Literature

Aggarwal,

Joshi,

Bhullar

2023

OAS

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Granular cell tumors (GCTs) are uncommon neoplasms that occur in various organs, including the integumentary system, respiratory tract, and gastrointestinal tract. Colonic granular cell tumors are rare and account for less than 0.5% of soft tissue tumors. The gross endoscopic diagnosis of colonic tumors can be challenging due to their submucosal predominance, and advanced endoscopic techniques are necessary for diagnosis and management. We present a rightsided granular cell tumor resected en bloc during colonoscopy and hypothesize that colonic granular cell tumors have a higher affinity for the right colon. The aim of this paper is to review the literature on granular cell tumors of the colon and assess the clinical and pathological characteristics, diagnosis, and management of granular cell tumors of the colon.

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Granular Data: A Rare Submucosal Tumor of the Colon—Case Report and Review of the Literature

Cited by 3 publications

References 40 publications

Granular Cell Tumor of the Anal Canal: Case Report and Literature Review

Granular Cell Tumor of the Anal Canal: Case Report and Literature Review

Diagnostic Endoscopic Ultrasound (EUS) of the Luminal Gastrointestinal Tract

Affinity of Colonic Granular Cell Tumor Within the Right Colon: Case Report and Review of Literature

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