Granular cell variant of dermatofibrosarcoma protuberans

Banerjee, Shiladitya; Harris, Martin; Eyden, Brian P; Hamid, Bushra

doi:10.1111/j.1365-2559.1990.tb00745.x

Cited by 79 publications

(36 citation statements)

References 3 publications

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“…Granular cells have been described in a number of skin tumours [9,10,11,12,13,14,15,16,17,18,19,20] (table 1) and they are thought to result from degenerative processes that can occur in tumours of neural, smooth muscle, vascular, melanocytic and epithelial differentiation.…”

Section: Discussionmentioning

confidence: 99%

Fibrous Papule of the Face with Granular Cells

2007

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Fibrous papule of the face is a common benign lesion located most often on the nose. It presents usually as a single small, firm, skin-coloured papule and is often misdiagnosed as melanocytic naevus, wart or small nodular basal cell carcinoma. Histopathologically, the lesions are characterized by involvement of the upper dermis by a fibrovascular proliferation and scattered triangular or stellate, often multinucleated cells. Uncommon histopathologic variants of fibrous papule of the face include hypercellular, clear-cell, pleomorphic, pigmented, inflammatory and granular-cell types. We present here a patient with the syndrome of familial cancer and fibrous papule of the face with granular cells. The granules stained strongly with PAS stain, as well as with CD68 and NKI/C3 immunostains, whereas S-100 protein resulted negative. In our patient the mutations in the 2 most often affected DNA mismatch repair genes of Muir-Torre syndrome were not found, therefore the origin of the familial cancer syndrome remains unknown. Probably the occurrence of the granular-cell fibrous papule of the face was coincidental.

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Section: Discussionmentioning

confidence: 99%

Fibrous Papule of the Face with Granular Cells

2007

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“…The differential diagnosis of the lesion examined includes many cutaneous neoplasms with granular cell changes, such as leiomyoma, leiomyosarcoma, angiosarcoma, basal cell carcinoma, schwannoma, dermatofibrosarcoma protuberans and dermatofibroma (5)(6)(7)(8)(9)(10)(11)(12)(13). It is particularly important that the neoplasm presented should be differentiated from a granular cell dermatofibroma due to simularities of architecture.…”

Section: Discussionmentioning

confidence: 99%

Dermatofibroma‐like Atypical Granular Cell Tumour

Hong¹,

Yang²,

Lee³

et al. 2005

Acta Dermato-Venereologica

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Sir, Granular cell tumours (GCTs) are uncommon tumours that occur at a wide range of sites (1) and are characterized by granular, acidophilic cytoplasm that contains abundant lysosomes upon ultrastructural examination (2). Although they vary considerably in cellular and nuclear morphology, tumour cells tend to cluster into aggregates, with some situated between bands of collagen. The nuclei are small, round and centrally located, with no mitoses. GCTs are shown to express S-100 protein upon immunohistochemical examination and to contain numerous pleomorphic secondary lysosomes, including occasional angulate forms upon ultrastructural examination. We describe an atypical GCT with a histological architecture resembling that of a dermatofibroma. CASE REPORTA 48-year-old man presented with a solitary, round, dome-shaped hard nodule, 1.061.0 cm in size, and slightly yellow in colour in the pubic area which had grown over a period of 4 years (Fig. 1). The nodule was slow-growing, fixed and painful when subjected to pressure. Examination of haematoxylin and eosinstained sections revealed that the tumour was situated in the reticular dermis with extension into the papillary dermis and associated with mild hyperplasia of the overlying epidermis with elongation of the rete ridges and hyperpigmentation of the basal layer (Fig. 2 top). The tumour was made up of sheets of cells arranged singly and in nests or lobules separated by thin delicate collagen bundles. At the periphery of the lesion, tumour cells were arranged in a whorled pattern, and appeared to be infiltrating the surrounding tissue. The tumour cells were oval, polygonal to spindle-shaped with distinct cellular borders. The majority of cells had abundant eosinophilic granular cytoplasm and small, bland, eccentrically placed nuclei, and considerable variation in cellular and nuclear size was noted. The tumour cell nuclei showed prominent nucleoli, pleomorphism and nuclear contour irregularities (Fig. 2 bottom); however, no mitosis or necrosis was seen. Immunohistochemical staining revealed that tumour cells showed immunoreactivity for S-100, vimentin, neuron-specific enolase and CD68. No immunopositivity for desmin, smooth muscle actin, CD34, CD57, alpha-1-antitrypsin, MAC387, factor VIII and factor XIIIa was observed. Electron microscopy revealed that the tumour was composed of Fig. 2. (top) Hyperplasia of the overlying epidermis and hyperpigmentation of the basal layer (haematoxylin and eosin, original magnification 640). (bottom) Tumour cells show nuclear pleomorphism and prominent nucleoli (6200).Fig. 1. A dome-shaped, hard nodule in the pubic area. Acta Derm Venereol 85 Letters to the Editor

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“…These peculiar cytoplasmic changes are typical and constant features of granular cell tumors. However, cellular granularity can be observed focally or extensively in numerous cutaneous and noncutaneous benign and malignant neoplasms of diverse histogenesis (table 1) [16, 17, 18, 19, 20, 21, 22, 23, 24]. Cytoplasmic granules are due to an increased number of secondary lysosomes and do not indicate a specific cellular lineage [21].…”

Section: Discussionmentioning

confidence: 99%

Dermatofibroma with Granular Cells: A Report of Two Cases

Aloi

Albertazzi²,

Pippione³

1999

Dermatology

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We describe two examples of an unusual variant of dermatofibroma (DF) in which areas of granular cells were a prominent feature. The diagnosis of DF was confirmed by immunohistochemistry and by ultrastructural studies. Granular cell changes can be observed in numerous benign and malignant cutaneous tumors of different cellular lineage. Cellular granularity is a nonspecific phenomenon characterized by intracytoplasmic accumulation of lysosomes and may cause diagnostic difficulties. Traumatic factors may be involved in the pathogenesis of cellular granularity.

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Granular cell variant of dermatofibrosarcoma protuberans

Cited by 79 publications

References 3 publications

Fibrous Papule of the Face with Granular Cells

Fibrous Papule of the Face with Granular Cells

Dermatofibroma‐like Atypical Granular Cell Tumour

Dermatofibroma with Granular Cells: A Report of Two Cases

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