Granular‐cell tumours of the skin do not express carcino‐embryonic antigen

Abstract

Granular-cell tumour (GCT) of the skin is an uncommon tumour of disputed histogenesis, that has been subjected to several immunohistochemical studies. The controversy existing in the literature concerning the expression of carcinoembryonic antigen (CEA) by GCT prompted us to study a series of 17 cases of cutaneous GCT by using an avidin-biotin-immunoperoxidase technique on routinely-processed tissue sections. No CEA activity was detected in any of the tumours screened. The reasons for this controversy are discussed.

Metastatic breast carcinoma mimicking granular cell tumor

“…While we did not perform staining for carcino-embryonic antigen (GEA), it would have been useful. None of 17 granular cell tumors stained positive for GEA, white breast carcinomas are frequently positive (13).…”

Ultrastructural pathology in man. French contributions

“…With electron microscopy combined with immunochemistry, the group confirmed the thymus-derived origin of Sezary's cells, and also studied samples from diverse clinical forms of histiocytosis (HX) [43]. In this respect, a monoclonal antibody produced from histiocytosis X cells was identified to react with the CD1 a molecule of human epidermal Langerhans cells as well as with the Langerhans cells of HX lesions [17].…”

“…In the dermis, the study of the histogenesis of Stewart-Treves' syndrome demonstrated the endothelial rather than the epithelial nature of the tumor cells [43].…”