Granular cell tumours of the orbit

McNab, Alan A.; Daniel, Susan E.

doi:10.1111/j.1442-9071.1991.tb00317.x

Cited by 12 publications

(6 citation statements)

References 25 publications

(2 reference statements)

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“…Consistent with a previous report, 27 we witnessed no recurrence following complete surgical removal. While McNab et al 14 once reported that many tumours with incomplete excision also exhibited no recurrence, in our cases (and in our review of the literature) 37.5% of benign GCTs with subtotal resection demonstrated tumour recurrence. Because two of the three tumours were S-100 negative, we cannot determine whether the recurrence was completely due to subtotal resection or due to the tumours' particular pathogenesis.…”

Section: Treatment and Prognosissupporting

confidence: 45%

Orbital granular cell tumours: clinical and pathologic characteristics of six cases and literature review

Qian

et al. 2016

Eye

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Objective To retrospectively assess the clinicopathological characteristics of orbital granular cell tumours (GCTs). Methods A non-comparative review of the clinical characteristics, imaging, histopathological features, management, and prognosis of five cases of benign GCT and one case of malignant GCT (MGCT) was conducted, along with a review of the English language literature. Results Among the six cases, four tumours were adherent to the extraocular muscle (EOM), and three tumours to the optic nerve (ON). Morphologic examinations revealed polygonal cells containing periodic-acid-Schiff-positive eosinophilic granules. All tumours (100%) were positive for VIM and NSE, five (83.3%) tumours were positive for S-100, and three (50%) tumours were positive for CD68. The follow-up examination of the MGCT witnessed recurrence and brain metastasis despite several thorough resections, but the patient remained alive; the follow-up examination of the four benign GCTs that had received incomplete excision revealed recurrence in one patient and dramatic shrinkage of the residual tumour in another; there was no recurrence in the other two patients. Conclusions GCT should be considered in the differential diagnosis of orbital tumours, which may affect EOMs and ON. The natural course of GCT can include tumour progression, stability, or spontaneous regression. To avoid recurrence, complete resection is recommended for orbital GCT. To the best of our knowledge, primary orbital MGCT is reported for the first time.

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Section: Treatment and Prognosissupporting

confidence: 45%

Orbital granular cell tumours: clinical and pathologic characteristics of six cases and literature review

Qian

et al. 2016

Eye

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“…19,23,24 The tumor's location is variable but it is commonly found in the lower half of the orbit (58.3%). 2 19,21 and lateral (2.8%). 25 The tumor was bilateral in just one case.…”

Section: Discussionmentioning

confidence: 99%

“…It is interesting that when diplopia was present before surgery, complete excision of the tumor did not improve eye motility in the majority of cases (73.3%). 6,12,[21][22][23]27,30,31 We found only one case of orbital malignant GCT that recurred and led to generalized metastasis. 8 Although there is some debate about whether CGT is a real entity, 34,35 most pathologists believe in a specific origin and a variety of cell types have been implicated in the histogenesis of the lesion, including myoblasts, 1,36 histiocytes, 37-39 perineurial fibroblasts, 40 and undifferentiated mesenchymal cells.…”

Section: Discussionmentioning

confidence: 99%

“…10 Nowadays, the preferred designation for this neoplasm is GCT. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] GCT may arise in many parts of the body, including skin, digestive tract, bronchi, trachea, female genitalia, breast, skeletal muscle, peripheral nerves, orbit, and pituitary stalk. 10 GCT rarely affects the orbit, and a literature survey disclosed only 39 reported cases.…”

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confidence: 99%

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Oculomotor Disturbances Due to Granular Cell Tumor

Ribeiro

Chahud

Cruz

2012

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Primary granular cell tumor of the orbit is a rare type of neoplasm. The tumor is frequently associated with extraocular muscles, and eye motility limitation is an unavoidable complication after its surgical removal. The objective of the present article is to review the literature on primary granular cell tumors of the orbit and to report a case of this uncommon neoplasia. Granular cell tumor is a benign lesion encountered in most cases (58.3%) in the inferior aspect of the orbit. Extraocular muscle involvement occurs in 72.2% of the patients, and diplopia is present in 77.1% of the cases. The inferior and medial recti are the most affected muscles (38.5% and 26.9%, respectively). Surgical excision is the only modality of treatment, but diplopia persists in 73.3% of the cases. In conclusion, granular cell tumor is a benign lesion but involves a high rate of extraocular muscle morbidity.

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“…These tumours have been reported in the meninges, choroid plexus, pituitary gland, trigeminal nerve, optic nerves, cerebellum, and spinal cord though they most are cerebral lesions [28,39,42,96,145,155]. However, limited understanding of this tumour exists due to its rarity and approximately 50 cases have been reported [155].…”

Section: Granular Cell Astrocytomamentioning

confidence: 99%

Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features

Karsy¹,

Gelbman²,

Shah³

et al. 2012

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A b s t r a c t Since the recent publication of the World Health Organization brain tumour classification guidelines in 2007, a significant expansion in the molecular understanding of glioblastoma multiforme (GBM) and its pathological as well as genomic variants has been evident. The purpose of this review article is to evaluate the histopathological, molecular and clinical features surrounding emerging and currently established GBM variants. The tumours discussed include classic glioblastoma multiforme and its four genomic variants, proneural, neural, mesenchymal, classical, as well as gliosarcoma (GS), and giant cell GBM (gcGBM). Furthermore, the emerging variants include fibrillary/epithelial GBM, small cell astrocytoma (SCA), GBM with oligodendroglial component (GBMO), GBM with primitive neuroectodermal features (GBM-PNET), gemistocytic astrocytoma (GA), granular cell astrocytoma (GCA), and paediatric high-grade glioma (HGG) as well as diffuse intrinsic pontine glioma (DIPG

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Granular cell tumours of the orbit

Cited by 12 publications

References 25 publications

Orbital granular cell tumours: clinical and pathologic characteristics of six cases and literature review

Orbital granular cell tumours: clinical and pathologic characteristics of six cases and literature review

Oculomotor Disturbances Due to Granular Cell Tumor

Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features

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