Granular Cell Tumour of the Larynx

Sproat, Rhona; Wong, Gentle; Rubin, John S.

doi:10.1007/s12105-016-0736-3

Cited by 16 publications

(12 citation statements)

References 8 publications

(11 reference statements)

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“…SIL with inverted growth pattern or tangentialing section can also be di cult to distinguish from invasive carcinoma. PEH, a not uncommon benign lesion occurring in the laryngeal mucosa, can be seen in chronic irritation, non-speci c in ammation, tumors such as granular cell tumor, laryngeal tuberculosis and fungal infections, or keratosis [16][17][18]. As the name PEH implies, the histomorphologic appearance assemble to invasive carcinoma and characterized with mucosal epithelial hyperplasia showing sub-epithelial extension in lamina propria.…”

Section: Discussionmentioning

confidence: 99%

The role of α-smooth muscle actin in confirming the microinvasion of laryngeal squamous cell carcinoma

Bai

Yue

et al. 2021

Annals of Diagnostic Pathology

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BackgroundThe diagnosis of microinvasive laryngeal squamous cell carcinoma (mLSCC) is not always straightforward and sometimes can be very challenge in daily clinical practice, particularly in the circumstances with differentials such as SIL with inverted growth pattern and PEH. The focus of the diagnosis is the con rmation of microinvasion. Cancer-associated broblasts (CAFs), as the major element of tumor microenvironment, are believed to participate actively in the invasion of tumor cells. In this study, we sought to evaluate the diagnostic role of α-SMA labelling CAFs in mLSCC, with comparison of laryngeal squamous intraepithelial lesion (SIL) and benign pseudoepitheliomatous hyperplasia (PEH). MethodsA total of 81 laryngeal biopsy specimens were retrieved, including 41 cases of mLSCC with depth of invasion no more than 3 mm, 20 laryngeal SIL, and 20 PEH. All tissues were stained for immunohistochemistry, using antibody against the α-SMA antigen. We observed the presence of α-SMA positive broblasts in mLSCC, compared the results with that of laryngeal SIL and benign PEH by Chisquare statistics test, and investigated the correlation between tumor histological characteristics and the presence of CAFs in mLSCC. ResultsImmunoreactivity of α-SMA was detected in twenty-nine mLSCC (29/41, 70.7%), while no reactivity was observed in laryngeal SIL (0/20, 0%), and few in PEH (2/20, 10%). The α-SMA expression pattern in stromal broblasts of mLSCC were signi cantly different from those of SIL (χ 2 = 26.966, p=0.000) and PEH (χ 2 = 19.838, p=0.000). This support that, α-SMA as an immunolabeling of CAFs plays a reliable role in con rming the microinvasion of LSCC. In addition , we nds that there is dense lymphoplasmacytic in ltration in the stroma of a few mLSCC (7/41, 17.1% ) cases rather than tumor-related desmoplastic hyperplasia. And it seems that there is a negative correlation between dense lymphoplasmacytic in ltration and the presence of CAFs in LSCC. ConclusionsOur study highlights practical role of utilizing α-SMA in the diagnosis of microinvasive laryngeal squamous cell carcinoma, with emphasis on variable histomorphologic features of mLSCCs.

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Section: Discussionmentioning

confidence: 99%

The role of α-smooth muscle actin in confirming the microinvasion of laryngeal squamous cell carcinoma

Bai

Yue

et al. 2021

Annals of Diagnostic Pathology

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“…Sproat et al detailed a case of GCT of the larynx excised with a CO 2 laser. Follow-up was characterized by complete recovery and absence of recurrence [12]. Crippa et al presented 11 cases of GCTs treated with 808 and 830 nm laser with no recurrence during 5 years follow up [13].…”

Section: Discussionmentioning

confidence: 99%

A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser

et al. 2020

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Oral granular cell tumor (GCT) is a relatively rare, benign lesion that can easily be misdiagnosed. Particularly, the presence of pseudoepitheliomatous hyperplasia might, in some cases, lead to the hypothesis of squamous cell carcinoma. Surgical excision is the treatment of choice. Recurrence has been reported in up to 15% of cases treated with conventional surgery. Here, we reported a case of GCT of the tongue in a young female patient, which was successfully treated through 445 nm diode laser excision. Laser surgery might reduce bleeding and postoperative pain and may be associated with more rapid healing. Particularly, the vaporization effect on remnant tissues could eliminate GCT cells on the surgical bed, thus hypothetically leading to a lower rate of recurrence. In the present case, complete healing occurred in 1 week, and no recurrence was observed after 6 months. Laser surgery also allows the possibility to obtain second intention healing. Possible laser-induced histopathological artifacts should be carefully considered.

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“…Granular cell tumour has been reported to occur in the soft tissues of the head, neck and other regions of the body including the larynx [4], suprasellar space [5], nasal septum [6], oral mucosa [7], mediastinum [8], buttock [9], vulva [10], back [11], rectum [12], etc. Granular cell tumour of the breast is rare and only a few case series have been studied so far [2].…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Presentation of a Case Report and Literature Review on Granular Cell Tumour of the Breast

Vhriterhire

Ngbea

Gyenger

et al. 2020

JAMMR

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A 21 years old woman presented with a breast swelling of 4 years duration and with an associated pain of a more recent onset. On clinical examination, the mass was found to be firm, mobile and without attachment to the skin or surrounding structures. An excisional biopsy was performed based on a provisional clinical diagnosis of fibroadenoma. However, histological evaluation showed the tumour to be a granular cell tumour. The clinical features of this rare tumour may mimic a variety of conditions and cause a diagnostic dilemma.

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Granular Cell Tumour of the Larynx

Cited by 16 publications

References 8 publications

The role of α-smooth muscle actin in confirming the microinvasion of laryngeal squamous cell carcinoma

The role of α-smooth muscle actin in confirming the microinvasion of laryngeal squamous cell carcinoma

A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser

Presentation of a Case Report and Literature Review on Granular Cell Tumour of the Breast

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