Granular cell tumour: malignant or benign?

Singh, Vivek Ajit; Gunasagaran, Jayaletchumi; Pailoor, Jayalakshmi

doi:10.11622/smedj.2015136

Cited by 45 publications

(52 citation statements)

References 9 publications

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“…This study confirmed characteristics of GCT as well as its management previously described in published reports such as a predilection to affect females more often than males, occurrence in a wide variety of locations, and excision alone as the primary treatment . Benign GCT appears to occur most often in the head neck region, while, as found in this study, malignant GCT occurs most frequently in the soft tissues and skin …”

Section: Discussionsupporting

confidence: 92%

“…We performed an analysis of mGCT using a large database representa- This study confirmed characteristics of GCT as well as its management previously described in published reports such as a predilection to affect females more often than males, 4-9 occurrence in a wide variety of locations, [10][11][12][13][14] and excision alone as the primary treatment. 1,4,8,9,14,15 Benign GCT appears to occur most often in the head neck region, while, as found in this study, malignant GCT occurs most frequently in the soft tissues and skin. 1,5,7 As mentioned above, the primary treatment of GCT has traditionally been surgical excision, without regional lymphadenectomy.…”

Section: Discussionsupporting

confidence: 60%

“…As mentioned above, the primary treatment of GCT has traditionally been surgical excision, without regional lymphadenectomy . Although seldom reported in the literature, lymph node dissection does occur.…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis to distant sites occurred in 11.4% of patients in the current study. A few reports have described patients with metastasis to distant sites such as the lung and bone . In the 1998 Fanburg‐Smith report, metastasis occurred in 50% of patients with mGCT .…”

Section: Discussionmentioning

confidence: 99%

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Malignant granular cell tumor: Clinical features and long‐term survival

Moten

Zhao

et al. 2018

Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Malignant granular cell tumor: Clinical features and long‐term survival

Moten

Zhao

et al. 2018

Journal of Surgical Oncology

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“…Patients with multifocal tumours are more likely to develop recurrence, although the criteria to determine multifocal tumours versus metastatic tumours are not clear 2. Wide local excision is accepted as the treatment of choice and generally results in excellent long-term control of GCTs,3 benign and atypical. Interestingly, the impact of positive margins varies, with some authors finding no correlation between margin status and recurrence rates 2.…”

Section: Introductionmentioning

confidence: 99%

Isolated limb infusion as a treatment option for malignant granular cell tumour

Tian

Fox

Pameijer³

2018

BMJ Case Reports

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A 54-year-old man presented with a painful lesion on the right posterior calf with MRI identifying a 5 cm lesion in the medial head of the gastrocnemius. He underwent wide local excision of the tumour, and the final pathology was consistent with atypical granular cell tumour. Three years later, he developed a recurrent right popliteal mass. Complete staging workup also identified multiple lung nodules and a caecal polyp that were consistent with metastatic granular cell tumour. He was started on pazopanib and deemed a poor candidate for palliative resection due to encasement of the popliteal vessels. The patient refused above-the-knee amputation (AKA) at that point and was evaluated for isolated limb infusion as an alternative. He received three cycles of isolated limb infusion within a 2-year period and achieved good response from the first two cycles. He underwent AKA 4 years after his diagnosis of malignant granular cell tumours and is currently doing well.

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Periorbital Mass in a 44-Year-Old Woman

2022

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A 44-year-old woman presented to the oculoplastic surgery clinic with a mass on the lateral canthus of her right eye. The mass had gradually grown over 2 months and was tender to palpation. She denied any vision changes, facial trauma, redness, or discharge from the lesion. She had an unremarkable ocular and medical history.On examination, visual acuity was 20/20 OD and 20/20 OS. Ocular motility was full and pupils were equal, round, and reactive to light. Her examination was notable for a 3-mm subcutaneous, firm, mobile, noncompressible lesion near the lateral canthus of the right eye without overlying erythema, warmth, telangiectasia, or ulceration (Figure 1). The rest of the ophthalmic and orbital examination was normal.

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Granular cell tumour: malignant or benign?

Cited by 45 publications

References 9 publications

Malignant granular cell tumor: Clinical features and long‐term survival

Malignant granular cell tumor: Clinical features and long‐term survival

Isolated limb infusion as a treatment option for malignant granular cell tumour

Periorbital Mass in a 44-Year-Old Woman

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