Granular cell tumour. Case report.

Abstract

Introduction: Granular cell tumour (GCT), alsocalled an Abrikossoff tumour, is a relatively rareneoplasm that usually develops between the fourthand sixth decades of life, with a slightly higherprevalence among female patients. Most GCTs areasymptomatic and are usually reported as incidentalfindings from endoscopy . Histologically, GCTs arecomposed of large polygonal cells containingnumerous eosinophilic granules.Case presentation: A 65-year-old woman withoutany symptoms was admitted for a preventativecolonoscopy. The biopsy revealed sessile serratedadenomas (adenomatous polyps) with low-gradedysplasia. The lesion in the caecum showed anintestinal mucosa with a subepithelial tumour, whichwas found to be positive for S-100 protein and couldcorrespond to Abrikossoff’s tumour.Conclusions: Due to the rare occurrence ofcolorectal Abrikossoff tumours in the colon, thereare very few reported cases, especially in malepatients. A colorectal GCT is a sporadic submucosaltumour that usually follows a benign course.Malignant GCT is extremely rare. The finaldiagnosis of GCT can be based on endoscopic biopsyand histopathological examinations. The basis ofbenign GCT treatment is endoscopic resection,which often leads to a cure.