Granular cell tumour (Abrikossoff’s tumour): Case series

Malignant Granular Cell Tumor of the Tongue: A Clinico-Pathological Challenge

“…In GCTSs involving the tongue, the pseudoepitheliomatous hyperplasia may be so pronounced that it can be misinterpreted as a squamous cell carcinoma [7]. Such an erroneous diagnosis can occur if the tissue biopsy fragment is either too small or too superficial [8]. Further, it has been suggested that fine needle aspiration cytology is inherently unreliable in the diagnosis of a GCT [7].…”

“…The malignant variety of GCT was first reported by Ravich et al in 1945who found the tumor akin to a high grade sarcoma with high frequency of metastasis and short survival. Some authors have suggested that the distinction between benign and malignant types is fairly difficult because there is striking histological similarity between both varieties and a lack of reliable criteria to provide a prediction of development of a malignant behavior [8]. It was therefore suggested that only the presence of regional and distant metastasis would aid in the differentiating benign GCTs from its malignant counterpart [7].…”

“…The prognosis of benign GCTs are generally good, recurrences are uncommon and are frequently a result of incomplete excision of the original lesion [8]. The prognosis of patients with the malignant GCTs are poor with frequent metastasis (>50 % overall) and 30-50 % mortality over 3 years [5].…”

Histochemistry and Immunohistochemistry Evaluation of the Abrikossoff’s Tumour of the Tongue: a Case Report

“…Može se nazvati i gigantocelularni tumor (GCT) ili mioblastom (My), jer naziv te novotvorine ovisi o histogenezi koja nije točno određena, pa su zato različiti istraživači postavili mnoge hipoteze o njegovu nastanku, uključujući fibroblaste, mioblaste, nediferencirane mazenhimne stanice, Schwanove stanice, histiocite i neuralne stanice (3,4).…”

“…It could be also called Granular cell tumour (GCT) or Myoblastoma (My), in fact, the denomination of this tumour depends on its real histogenesis, which remains unsettled, since different derivations have been postulated by various authors, including fibroblasts, myoblasts, undifferentiated mesenchymal cells, Schwann cells, histiocytes and neural cells (3,4).…”