Granular cell tumors of the gastrointestinal tract and perianal region A study of 74 cases

Abstract

Seventy-four patients with 75 examples of granular cell tumors occurring in the gastrointestinal tract and perianal region were studied. Twenty-four were located in the esophagus, eight in the stomach, three in the small bowel, four in the appendix, twenty in the large bowel, and sixteen in the perianal region. Nine cases had multiple tumors either occurring in the same area of the bowel or in other organs, mostly the skin. Approximately 50% of the tumors occurring in the esophagus and perianal region showed varying degrees of acanthosis or pseudoepitheliomatous hyperplasia. In the perianal tumors the pseudoepitheliomatous hyperplasia was much more extensive and could be mistaken for squamous cell carcinoma. The world literature was reviewed and a total of 66 cases of granular cell tumors were reported in the area of study. In neither our 74 nor the other reported cases was there evidence of recurrence or malignant behavior of the tumors, thus confirming their benign biologic behavior.

Tumor de células granulares

“…En la actualidad prácticamente nadie discute su origen neural (células de Schwann) [2][3][4][5][6][7] .…”

“…Las localizaciones más frecuentes son la mucosa bucal (lengua 30%), la dermis y el tejido celular subcutáneo, aunque puede localizarse en cualquier otra parte del cuerpo: mama (6%), laringe, bronquios, esófago, estómago, apéndice, ano, conductos biliares, páncreas, vejiga, útero, vulva [2][3][4][5][6][7][8][9][10] . En el 10-16% de los casos, su localización puede ser múltiple 8 .…”

“…Más frecuente en la 4º-6ª década de la vida y en mujeres 2,3,6 . Las localizaciones más frecuentes son la mucosa bucal, la dermis y el tejido celular subcutáneo, aunque puede localizarse en cualquier otra parte del cuerpo [2][3][4][5][6][7][8][9][10] . La mayor parte de los tumores tienen una naturaleza benigna, encontrándose un 2% de formas malignas.…”

Granular Cell Tumor of the Cervical Esophagus: Case Report and Literature Review of an Unusual Cause of Dysphagia

“…GCTs of the cervical portion of the esophagus are particularly rare. In reviews of gastrointestinal tract GCTs, the incidence of cervical esophageal lesions has been found to be 1.3 % of all gastrointestinal GCTs, and only 4.2-5 % of all esophageal GCTs [2,3]. Due to the rarity of this lesion and its benign pathology, prescribed treatment protocols have not been elucidated; however, some have recommended observation alone for lesions less than one centimeter [4].…”

Granular Cell Tumor in the Ascending Colon.

“…It frequently occurs in the tongue and skin (1), but can also arise in the respiratory system (2), heart (3), breast (4-6), biliary system (7), nervous system (8), urinary tract (9) and gastrointestinal tract (6,(10)(11)(12)(13).…”