Granular cell tumors: a report of six cases

Abstract

Granular cell tumor is a soft tissue neoplasm that originates in the nervous system and arises at virtually any body site, but is mainly found in the skin, oral cavity or digestive tract. Most are benign and reportedly malignant cases are rare, occurring in only 1% or 2% of cases. We report on our findings in six patients who developed granular cell tumor in the mammary gland, esophagus, subcutaneous tissue and muscle. Of six patients, two had granular cell tumor located in the breast, two in the submucosa of the esophagus, and the other two under the skin of the left axillary cavity and in the right latissimus dorsi muscle, respectively. One of the two patients with tumor in the submucosa of the esophagus also had esophageal cancer. Patients’ age ranged from 41 to 70 years (average, 59.1 years). Two patients with tumor in the submucosa of the esophagus were men, and the others were women. All of them were given a diagnosis of granular cell tumor by tissue biopsy and examination of excised specimens, but no evidence of malignancy was found. No recurrence has been noted in the patients who underwent surgical tumor removal.

Tumor de células granulares de la vulva: caso clínico

“…Las células se distribuyen en láminas y nidos de tamaño variable, que parecen infiltrar los haces de colágeno y músculo 2,3,5,6,7 Los hallazgos microscópicos suelen ser suficientes pero la inmunohistoquímica es útil para confirmar el diagnóstico: presenta positividad para la proteína S-100 ( fig.3). También se ha descrito positividad para CD68, CD57 (Leu-7), enolasa neuronal específica, laminina, lecitina, HLA-DR, proteína básica de la mielina, y el antígeno carcinoembrionario (CEA), aunque hay casos CEA negativos 5,7 .…”

Atypical Granular Cell Tumor with Intranuclear Inclusions: A Case Report

“…Atypical and malignant granular cell tumors account for less than 2% of the granular cell tumors (4,5,6). These tumors primarily affect adults even though it may be found in children also (7).…”

Granular Cell Tumor of Breast: a Case Report and Review of Literature

“…Most of them are benign and reportedly malignant cases are rare (1 % or 2 %) [1]. It was first reported by Abrikossoff by the name of granular cell myoblastoma.and considered to be derived from muscle, due to its localization in tongue and pharynx in the first reported cases [2]. Studies using S100 staining and electron microscopy found that the tumor cells originate in Schwann cells of peripheral nerves [3,4].…”

“…Resection with adequate margins is necessary because the tumor has no capsule and is proliferation invasive [2]. However long-term risk for disease progression is low.…”