Granular cell tumor of the breast: a case report and review of literature

Filipovski, Vanja; Banev, Saso; Janevska, Vesna; Dukova, Blagica

doi:10.4076/1757-1626-2-8551

Cited by 18 publications

(32 citation statements)

References 12 publications

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“…Because of the positivity of the tumor for S-100 protein, and the similarities of the tumor cells to Schwann cells on electron microscopy, the most widely accepted pathogenetic theory is that the lesion originates from the Schwann cells of interlobular breast tissue [3]. This tumor is more frequent in women between their 40th to 60th decades and is more common in African Americans than in Caucasians [11][12]. All four patients with this type of tumor in our study were female patients with a median age of 55 years; three of them were Caucasians and one was African American.…”

Section: Discussionmentioning

confidence: 99%

Rare Mesenchymal Breast Entities that Mimic Malignancy: A Single-institution Experience of a Challenging Diagnosis

Simões

Qiu

Nguyen

et al. 2019

Cureus

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Background Benign mesenchymal tumors of the breast are rare and may mimic invasive carcinoma on imaging and morphology, thus becoming clinically challenging for clinicians, radiologists, and pathologists. To improve the understanding of these lesions and to avoid erroneous diagnosis and inappropriate treatment, we report our institution's experience with seven cases of granular cell tumor (GCT) and myofibroblastoma (MFB) in the past 10 years.

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Section: Discussionmentioning

confidence: 99%

Rare Mesenchymal Breast Entities that Mimic Malignancy: A Single-institution Experience of a Challenging Diagnosis

Simões

Qiu

Nguyen

et al. 2019

Cureus

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“…Supraklaviküler sinirin cilt duyu dalları memenin üst iç kadranında seyir gösterdiği için en sık bu alanda görülürler (6).…”

Section: Discussionunclassified

Mammography, Ultrasonography and Sonoelastography Findings of Granular Cell Tumor in Accessory Axillary Breast

Yılmaz¹,

Yılmaz²,

Pehlivan³

et al. 2017

JAREM

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ÖZMeme radyolojisinde temel amaç; lezyonu tespit etmek ve benign ya da malign ayrımına yüksek doğrulukla karar vermektir. Sonoelastografi (SE) incelemesinin son yıllarda ultrason (US) bulgularına ek olarak özgüllüğü artırdığı ifade edilmektedir. Granüler hücreli tümörler memede çok nadir görülür. Mamografide genellikle sınırları belirsiz asimetrik dansite şeklinde görünürken, ultrasonografide yoğun gölge veren, düzen-siz sınırlı kitle(ler) şeklinde izlenir ve malign kitleleri taklit ederler. Olgumuzda kitlenin mamografi ve US özelliklerine ek olarak SE bulgularını da değerlendirdik. Kitlenin elastisite değeri ve oranı malign kitlelerle benzerlik gösterdiğinden SE'nin bu lezyonlarda tanıya ilave katkı sağla-madığı sonucuna vardık.Anahtar kelimeler: Elastografi, sonoelastografi, granüler hücreli tümör ABSTRACTThe main objective of breast imaging is to detect and differentiate benign lesions from malignant ones with higher accuracy rates. Recent studies have reported that sonoelastography (SE) is helpful for distinguishing benign and malignant solid breast masses and shows higher specificity than B-mode ultrasound (US) alone. Granular cell tumors are rare stromal tumors. While mammographically, they appear to be indistinctly marginated asymmetric density, sonographically the lesion generally shows acoustic shadowing and an irregular shape. In our case, in addition to mammography and US findings, we evaluated SE findings as well. The elasticity value and elasticity ratio showed similarity with malignant masses; therefore, we conclude that SE has no additional contribution to diagnosis of these lesions.

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“…[15] Bu sitoplazmik granüllerin, büyük oranda asit fosfataz benzeri hidrolitik enzimler içerdiği gösterilmiştir. Bu granüller ultrastrüktürel olarak lizozom gö-rünümündedirler.…”

Section: Discussionunclassified

A rare granular cell tumor of the vulva: a case report

KAPLAN¹

2015

TJ Oncol

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Granular cell tumors are rare tumors, usually located subcutanesously or intramucosal. Most frequent presentation is in the head and neck region especially in the tongue, 5-15% of the cases are vulvar. Originating from Scwhan cells, these tumors are usually benign and only 1-3% of the cases have malign behaviour. As these tumors have an agressive course and do not respond to chemo-radiation, to mention the importance of early diagnosis we present this case. Granüler hücreli tümörler, sıklıkla subkutan dokuda veya mukozada yerleşim gösterir ve nadir görülür. En sık baş-boyun bölgesinde ve dilde yerleşimlidir, %5-15 oranında vulvada görülür. Schwan hücrelerinden köken aldığı bilinen bu tü-mörler, genellikle benign olup %1-3 oranda malign davranış gösterirler. Malign granüler hücreli tümörlerin agresif seyirli olması ve kemoterapi-radyoterapiye cevap vermemesi nedeni ile erken tanının önemini vurgulamak için bu olgu sunuldu.

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Granular cell tumor of the breast: a case report and review of literature

Cited by 18 publications

References 12 publications

Rare Mesenchymal Breast Entities that Mimic Malignancy: A Single-institution Experience of a Challenging Diagnosis

Rare Mesenchymal Breast Entities that Mimic Malignancy: A Single-institution Experience of a Challenging Diagnosis

Mammography, Ultrasonography and Sonoelastography Findings of Granular Cell Tumor in Accessory Axillary Breast

A rare granular cell tumor of the vulva: a case report

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