Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases

An, Soyeon; Jang, Jaejung; Min, Kwangseon; Kim, Min-Sun; Park, Hosub; Park, Young Soo; Kim, Jihun; Lee, Jeong Hoon; Song, Ho June; Kim, Kyung‐Jo; Yu, Eunsil; Hong, Seung‐Mo

doi:10.1016/j.humpath.2015.02.005

Cited by 68 publications

(77 citation statements)

References 23 publications

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“…In previous immunohistochemical studies on GCTs of the gastrointestinal tract, high expression of CD56 as well as S‐100 protein was confirmed, with corresponding results obtained in the present case. Positivity for neuronal markers, including S‐100 protein and CD56, is regarded as the major evidence for the neuronal origin of GCT.…”

Section: Discussionsupporting

confidence: 90%

Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor

Kang

Yoon

et al. 2016

Head & Neck

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Section: Discussionsupporting

confidence: 90%

Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor

Kang

Yoon

et al. 2016

Head & Neck

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“…But due to the fact that GCTs are rare tumours and prospective studies are lacking, reliability of these criteria based on a small number of patients is limited. In a Korean study, a malignant colonic GCT was found that was considered as a benign variant according the criteria provided by Fanburg-Smith 5. This case challenges the established criteria and therefore the preferred treatment of detected colonic GCT is complete resection.…”

Section: Discussionmentioning

confidence: 92%

Simultaneous endoscopic full-thickness resection of two synchronous colonic granular cell tumours

et al. 2018

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Granular cell tumours (GCTs) are rare soft tissue tumours originating from Schwann cells. Due to potential malignant transformation, complete endoscopic resection should be aimed for. We report on a 49-year-old patient with two synchronous GCTs found in the caecum and the ascending colon, respectively. Synchronous endoscopic full-thickness resection (EFTR) using an all-in-one full-thickness resection device (FTRD) was performed under propofol sedation. Completeness of resection was proven histologically. No adverse events occurred. We report safe and complete simultaneous EFTR of two synchronous colonic GCTs.

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“…The ones that have similar growth pattern as GCT are more difficult to diagnose, but some characteristics are different and immunohistochemistry can be helpful (4,19). Congenital epulis of newborn, leiomyoma, rhabdomyoma and oncocytoma can show a major presence of granular cell proliferation ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect

Pl¹,

Fm²,

Mc³

et al. 2016

Med Oral

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BackgroundGranular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses.Material and MethodsWe retrieved all cases diagnosed with oral granular cell tumor, from the Oral Pathology Service at the School of Dentistry/ University of São Paulo, and excluded the ones sited in the tongue. Immunohistochemical staining anti-S100 was also performed.ResultsThe presented cases of Extra-tongue Oral Granular Cell Tumor (ETOGT) are composed by granular cells with intimately association with the adjacent tissue. Atypia and mitoses were not seen, and in most cases, the typical pseudoepitheliomatous hyperplasia was not observed.ConclusionsThe importance of an adequate attention is to avoid misdiagnoses, since ETOGT is rare and the tricking histopathological findings could induce to it. All the cases can be differentiated from the tumors that has a granular cell proliferation through a morphological analysis and when needed, immunohistochemistry stain. Key words:Abrikossoff`s tumor, granular cell tumor, oral cavity.

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Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases

Cited by 68 publications

References 23 publications

Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor

Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor

Simultaneous endoscopic full-thickness resection of two synchronous colonic granular cell tumours

Extra-tongue oral granular cell tumor: Histological and immunohistochemical aspect

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