Granular cell tumor of the breast

Aouni, Nadra El; Laurent, Isabelle; Terrier, Philippe; Mansouri, Dhouha; Suciu, Voïchita; Delaloge, Suzette; Vielh, Philippe

doi:10.1002/dc.20736

Cited by 31 publications

(50 citation statements)

References 12 publications

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“…[17] The fragile granular cytoplasm of GCT can lead to a “dirty” background synonymous with necrosis that can be seen in breast carcinoma and other malignancies. [18] In the cases where GCT shows a degree of cellular and nuclear atypia, apocrine cancer and metastatic lesions such as renal cell carcinoma and melanoma must be ruled out. [16] This is accomplished with immunohistochemical stains such as S-100, vimentin, and CEA.…”

Section: Discussionmentioning

confidence: 99%

Is fine needle aspiration cytology a useful diagnostic tool for granular cell tumors? A cytohistological review with emphasis on pitfalls

2014

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Background:Granular cell tumors (GCT) formerly known as Abrikossoff tumor or granular cell myoblastoma, are rare neoplasms encountered in the fine needle aspiration (FNA) service. Named because of their highly granular cytoplasm which is invariably positive for the S-100 antibody, the classic GCT is thought to be of neural origin. The cytomorphological features range from highly cellular to scanty cellular smears with dispersed polygonal tumor cells. The cells have abundant eosinophilic granular cytoplasm, eccentric round to oval vesicular nuclei with small inconspicuous nucleoli. The fragility of the cells can result in many stripped nuclei in a granular background. The differential diagnosis occasionally can range from a benign or reactive process to features that are suspicious for malignancy. Some of the concerning cytologic features include necrosis, mitoses and nuclear pleomorphism.Methods:We identified 6 cases of suspected GCT on cytology within the last 10 years and compared them to their final histologic diagnoses.Results:Four had histologic correlation of GCT including one case that was suspicious for GCT on cytology and called atypical with features concerning for a malignant neoplasm. Of the other two cases where GCT was suspected, one showed breast tissue with fibrocystic changes, and the other was a Hurthle cell adenoma of the thyroid.Conclusions:These results imply that FNA has utility in the diagnosis of GCT, and should be included in the differential diagnoses when cells with abundant granular cytoplasm are seen on cytology. Careful attention to cytologic atypia, signs of reactive changes, use of immunohistochemistry, and clinical correlation are helpful in arriving at a definite diagnosis on FNA cytology.

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Section: Discussionmentioning

confidence: 99%

Is fine needle aspiration cytology a useful diagnostic tool for granular cell tumors? A cytohistological review with emphasis on pitfalls

2014

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“…2 The GCT of the breast accounts for between 5 and 15% of all GCT cases. It occurs in a wide range of ages from teenagers to elderly, most commonly in women between 30 and 50 years.…”

Section: Discussionmentioning

confidence: 99%

Atypical Granular Cell Tumor of Breast

Maheshwari¹

2017

MGM Journal of Medical Sciences

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Breast carcinomas are the leading cause of mortality and morbidity in the female population. Granular cell tumor (GCT) is a rare tumor, which commonly involves the tongue, lower extremity, skin, and digestive tract. It is derived from Schwann cells. Benign and malignant GCTs exist but the criteria that define them are poorly stated in the literature. Our case is an unusual case of atypical GCT in a 52-year-old female who presented with left breast lump. The diagnosis was confirmed by immunohistochemistry. Early diagnosis and intervention in such cases is critical to increase patient survival and reduce postoperative morbidity and mortality.

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“…5,13 Most reports published on the histological features of GCTs have been on lesions from the breast, respiratory tract or digestive tract. [1][2][3]5,6 Few reports have been on the diagnosis of GCTs by fine needle aspiration cytology. 4,5,7,[9][10][11] One report described a case of GCT in the inguinal region that was misdiagnosed by cytology, 4 while another reported that GCT of the breast could be misdiagnosed as breast cancer when using fine needle aspiration cytology.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] The majority of GCTs are benign, but they are often misdiagnosed, based on clinical and cytological tests and examination of frozen sections. [4][5][6] There have been few reports on the cytopathological examination of GCTs. [7][8][9][10][11] The present case report describes the cytological features of a GCT of the abdominal wall, which was diagnosed by fine needle aspiration cytology and confirmed by histology.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of a granular cell tumour at the abdominal wall using fine needle aspiration cytology and histology: Case report

et al. 2015

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This case report describes the use of fine needle aspiration cytology to diagnose a granular cell tumour (GCT) that presented as a painless, palpable mass at the abdominal wall in a 50-year-old woman who had had the mass for !1 year prior to presentation. Routine haematoxylin and eosin staining of the cytological smears demonstrated that the specimen was predominantly cellular; it contained both cell clusters and single cells with abundant granular cytoplasm and indistinct cell borders. Cells were fragile and had fairly uniform naked nuclei that were scattered with vacuolated and prominent nucleoli. Background material on the smears included eosinophilic, granular cytoplasmic material and some adipose tissue. Neither mitoses nor necrosis were observed. A cytological diagnosis of a GCT was confirmed by histological examination of a surgical specimen stained with haematoxylin and eosin. This case report found that the GCT had a characteristic cytological appearance and that cells with prominent nucleoli can be present in benign GCTs.

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Granular cell tumor of the breast

Cited by 31 publications

References 12 publications

Is fine needle aspiration cytology a useful diagnostic tool for granular cell tumors? A cytohistological review with emphasis on pitfalls

Is fine needle aspiration cytology a useful diagnostic tool for granular cell tumors? A cytohistological review with emphasis on pitfalls

Atypical Granular Cell Tumor of Breast

Diagnosis of a granular cell tumour at the abdominal wall using fine needle aspiration cytology and histology: Case report

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