Granular cell tumor of the urinary bladder

Bedir, Recep; Yılmaz, Rukiye; Özdemir, Oğuz; Uzun, Hakkı

doi:10.5152/tud.2017.44538

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…As only sporadic cases of bladder GCT have been reported, there are no explicit criteria for the treatment of this disease. Most bladder GCT cases are benign, and only two malignant cases have been reported, and distant metastasis of GCT from the primary organ to the bladder should not been neglected[ 1 , 2 ]. It is usually difficult to distinguish GCT from other neurogenic tumors by simply depending on radiologic and pathological findings without immunohistochemical (IHC) staining.…”

Section: Introductionmentioning

confidence: 99%

Atypical granular cell tumor of the urinary bladder: A case report

Wei

Yan

Jiang

et al. 2021

WJCC

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BACKGROUND Granular cell tumor (GCT) is a neurogenic tumor mainly occurring in the head and neck. GCT in the genitourinary system is extremely rare and only sporadic cases of urinary bladder GCT have been reported. Most urinary bladder GCT cases are benign and only two malignant cases have been reported. Due to its rarity, no consensus criteria for the treatment of urinary bladder GCT are available at present. CASE SUMMARY A 62-year-old Chinese woman was found to have a urinary bladder tumor without any clinical manifestations on physical examination. Cystoscopy revealed a semispherical shaped lesion measuring approximately 4.0 cm in diameter at the junction of the left wall and roof of the bladder, which was covered with normal bladder mucosa. Computed tomography scan demonstrated a high-density lesion on the left wall of the bladder, measuring approximately 2.9 cm × 2.4 cm with clear boundaries. Contrast-enhanced pelvic magnetic resonance imaging revealed a space-occupying lesion on the left wall of the bladder (non-mucosal origin/ external pressure), which was preliminarily suspected to be a desmoplastic fibroma or leiomyoma. In the context of the above findings, a pre-operative diagnosis of bladder leiomyoma was made. The patient consequently underwent a laparoscopic partial cystectomy. The resected bladder mass looked yellowish and well-demarcated, measuring 4.0 cm × 3.5 cm and infiltrated the muscular layer. The diagnosis of urinary bladder GCT was finally made by postoperative pathology, with positive immunohistochemical S-100 staining and negative pancytokeratin. The patient has been followed for 6 mo so far, with no tumor recurrence detected. CONCLUSION This case highlights the biological feature and differential diagnosis of urinary bladder GCT at the pathological and molecular levels. Transurethral resection of the bladder tumor and partial cystectomy are recommended in most urinary bladder GCT cases, while radical cystectomy is recommended in malignant cases.

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Section: Introductionmentioning

confidence: 99%