Granular cell tumor a study of 42 cases and systemic review of the literature

Mobarki, Mousa; Dumollard, Jean Marc; Col, Pierre Dal; Camy, Florian; Péoc’h, Michel; Karpathiou, Georgia

doi:10.1016/j.prp.2020.152865

Cited by 60 publications

(87 citation statements)

References 54 publications

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“…Besides, PC still has a dismal 5-year survival rate below 5% despite improvement of survival for the patients undergoing surgical resections. 4 This suggested that current criteria are not appropriate to select patients who might benefit from surgeries. Currently, carbohydrate antigen 19-9 (CA19-9) has been used widely in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic Ultrasound-Guided Acquisition of Portal Venous Circulating Tumor Cells as a Potential Diagnostic and Prognostic Tool for Pancreatic Cancer

Zhang¹,

Su²,

Wang³

et al. 2021

CMAR

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Background: Circulating tumor cells (CTCs) were a promising liquid biopsy for pancreatic cancer (PC) but circulate in low counts in peripheral blood. We evaluated the diagnostic and prognostic values of portal vein (PoV) CTCs in PC patients. Methods: PoV was aspirated under EUS guidance from 40 patients with suspected pancreaticobiliary cancers. Epithelial-mesenchymal-transition-related subtypes of CTCs were identified via immunofluorescence using EpCAM and Twist antibodies. The diagnostic and prognostic performance of PoV CTCs was investigated by receiver-operating characteristic (AUC) curve and Kaplan-Meier survival analysis. Results: In total, 40 patients including 31 with PC, 4 with non-pancreatic periampullary cancer and 5 with benign pancreatic diseases (BPD) were enrolled. CTCs were detected more in PoV compared with peripheral blood. PoV CTC numbers in BPD patients were lower than in PC patients. The number of PoV CTCs, especially mesenchymal-CTCs (M-CTCs), was positively correlated with the tumor burden, instead of epithelial-CTCs (E-CTCs). The combination of PoV CTC numbers and CA19-9 demonstrated better diagnostic efficiency (AUC value 0.987) than either alone in differentiating PC with BPD. Moreover, the diagnostic efficacy of PoV CTCs and M-CTCs were obviously better than that of E-CTCs and CA19-9 in distinguishing early and late stage PC. Lastly, high PoV CTC and M-CTC numbers were both associated with shorter overall survival. Conclusion: Acquisition of the PoV samples in PC patients via EUS-guided procedures has been proved safe and feasible. PoV CTCs, especially M-CTCs, have great potentials in diagnosing and predicting the prognosis of PC, especially in combination with CA19-9.

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Section: Introductionmentioning

confidence: 99%

Endoscopic Ultrasound-Guided Acquisition of Portal Venous Circulating Tumor Cells as a Potential Diagnostic and Prognostic Tool for Pancreatic Cancer

Zhang¹,

Su²,

Wang³

et al. 2021

CMAR

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“…Although typically benign, malignant GCTs represent approximately 2% of reported cases, and histopathologic evaluation of undifferentiated growths is warranted to determine appropriate etiology and treatment. 4,5 The histopathologic examination of the tissue did not reveal any malignant features such as necrosis, cellular atypia, high mitotic rate, or lymphovascular invasion, ruling out malignant GCT. 3 The preferred treatment for GCTs is wide local excision with close follow-up to monitor for recurrence.…”

Section: Discussionmentioning

confidence: 96%

Atypical granular cell tumor developing within a tattoo

et al. 2020

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“…Small intestine involvement is extremely rare (<1%), with only few cases of this tumour affecting the duodenum and ileum (Barakat et al., 2018; Nakachi et al., 2000; Radaelli & Minoli, 2009). Most gastrointestinal granular cell tumours in human medicine arise from the mucosal or submucosal layer (Mobarki et al., 2020; Nakachi et al., 2000). In the present case, the lesion was in close contact with the serosal layer and mesenteric adipose tissue, being the other intestinal layers normal in ultrasound and computed tomography.…”

Section: Discussionmentioning

confidence: 99%

“…Granular cell tumours, once called granular cell myoblastomas, are uncommon and usually benign lesions in both human and veterinary medicine. The oral cavity (notably the tongue) is the most common location in dogs, cats and people, but a wide range of other locations have been described (Higgins et al., 2017; Levitin et al., 2019; Mobarki et al., 2020; Patnaik, 1993). In dogs, documented locations for this type of tumour include the brain, meninges, spinal nerve root, heart, lung, eye, vocal cord and trachea (Levitin et al., 2019; Patnaik, 1993).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic imaging and pathological findings of an abdominal mesenteric granular cell tumour in a dog

Ororbia

Sanz

Novellas

et al. 2021

Veterinary Medicine & Sci

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A 12‐year‐old mixed‐breed dog was presented for a follow‐up examination after ablation of an auricular mast cell tumour. An abdominal ultrasound and computed tomography were performed and an irregular, ill‐defined and partially mineralised lesion was observed around the caudal duodenal flexure without evidence of metastasis. The cytologic examination was highly suggestive of a granular cell tumour. Partial surgical ablation with histological and immunohistochemical examination of the lesion confirmed the diagnosis. According to our review of the literature, this is the first report documenting an abdominal granular cell tumour in a dog.

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Granular cell tumor a study of 42 cases and systemic review of the literature

Cited by 60 publications

References 54 publications

Endoscopic Ultrasound-Guided Acquisition of Portal Venous Circulating Tumor Cells as a Potential Diagnostic and Prognostic Tool for Pancreatic Cancer

Endoscopic Ultrasound-Guided Acquisition of Portal Venous Circulating Tumor Cells as a Potential Diagnostic and Prognostic Tool for Pancreatic Cancer

Atypical granular cell tumor developing within a tattoo

Diagnostic imaging and pathological findings of an abdominal mesenteric granular cell tumour in a dog

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