Granisetron reduces vomiting after strabismus surgery and tonsillectomy in children

Abstract

Granisetron is effective in the prevention of retching and vomiting after strabismus repair and tonsillectomy in paediatric patients.

Effective dose of granisetron for preventing postoperative emesis in children

“…This was in agreement with our previous study. 3 Granisetron has already been reported to be effective in the treatment of nausea and vomiting for preventing emesis induced by cancer chemotherapy, t It has also been reported recently that it is effective in reducing the frequency of these symptoms after surgery in children as well as in adults. 2;3 Although the exact mechanism of granisetron in the prevention of postoperative emesis is not known, it has been suggested that it may act on sites containing 5-HT 3 receptors with demonstrated antiemetic effects.…”

“…This was in accordance with our previous study for children. 3 The exact reason for this difference is not known, but it may be attributed to the difference in age and relatively small number of subjects. Further studies are needed to verify the safety of granisetron before it can be routinely used to prevent postoperative emesis.…”

Antiemetic efficacy of granisetron and metoclopramide in children undergoing ophthalmic or ENT surgery

“…2 The results of this study, with administration of placebo or granisetron, showed that the frequencies of postoperative retching and vomiting during the first three and the next 21 hr after anaesthesia in subjects who had received granisetron were lower that those in subjects who had received placebo. This was in accordance with our previous results.…”

Obstructive sleep apnea and tonsillectomy: do we have a new indication for extended postoperative observation?

“…14 The next genera-EDITORIAL tion of cyclooxygenase-2 selective inhibitors (COX-2) may be very useful for providing analgesia in this population since they seem to have minimal effects on platelet function and adequately treat moderate levels of pain. 15 Postoperative nausea and vomiting are generally treated with 5 HT3 antagonists 16,17 while the postoperative swelling (plus the vomiting) is treated with varying doses of dexamethasone (0.2-0.5 mg·kg -1 up to 12 mg). 18,19 The most common at home analgesic is acetaminophen with codeine.…”

“…15 Les nausées et les vomissements postopératoires sont généralement traités avec des antagonistes de 5HT3 16,17 tandis que l'oedème postopératoire, et les vomissements, sont traités avec diverses doses de dexaméthasone (0,2-0,5 mg·kg -1 jusqu'à 12 mg). 18,19 L'analgésique le plus commun utilisé à la maison est l'acétaminophène avec de la codéine.…”