Grandmaternal smoke exposure reduces female fertility in a murine model, with great-grandmaternal smoke exposure unlikely to have an effect

Camlin, Nicole J.; Ag, Jarnicki; Vanders, Rebecca L.; Walters, Kirsty A; Hansbro, Philip M.; McLaughlin, Eileen A.; Holt, J.G.H.

doi:10.1093/humrep/dex073

Cited by 10 publications

(6 citation statements)

References 43 publications

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“…In animal models, experimental studies showed that exposure to maternal smoking, similar to study findings regarding maternal nutritional status, was related to negative reproductive health outcomes in the adult offspring, including indicators of sub-fertility, lower ovarian reserve, and increased oxidative stress [68][69][70]. Consistent with these findings, in a prior study of women, maternal smoking during pregnancy was associated with earlier menopausal timing in the offspring [41].…”

Section: Discussionsupporting

confidence: 54%

Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?

Bleil

English

Valle

et al. 2018

womens midlife health

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Background: Because the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian follicle loss and the eventual onset of menopause. Building on a robust literature linking socioeconomic status (SES) and menopausal timing, the current study examined adverse prenatal exposures related to maternal SES, hypothesizing that greater maternal socioeconomic disadvantage would be associated with lower ovarian reserve in the adult offspring. Methods: In a healthy, community-based sub-sample (n = 350) of reproductive age participants in the OVA Study (2006)(2007)(2008)(2009)(2010)(2011), prenatal maternal SES was examined in relation to two biomarkers of ovarian reserve, antimullerian hormone (AMH) and antral follicle count (AFC). Prenatal maternal SES was assessed indirectly using maternal addresses abstracted from participant birth certificates, geocoded, and linked to US Census-derived variables, including neighborhood-level characteristics: education (% of individuals with a HS diploma); poverty (% of families below the poverty line); unemployment (% of individuals > 16 years who are unemployed); and income (median family income). Results: In separate covariate-adjusted linear regression models (following the backward elimination of main effects with P > .10), greater maternal neighborhood education was related to higher ovarian reserve as marked by higher levels of offspring AMH (beta = .142, P < .001) and AFC (beta = .092, P < .10) with models accounting for 19.6% and 21. 5% of the variance in AMH and AFC, respectively. In addition, greater maternal neighborhood poverty was related to lower ovarian reserve as marked by lower offspring AMH (beta = −.144, P < .01), with the model accounting for 19.5% of the variance in AMH. Conclusions: Maternal socioeconomic disadvantage measured indirectly at the neighborhood level was associated with lower ovarian reserve among the adult offspring, independently of offspring SES and other potential confounding factors. This suggests SES-related adversity exposures may have a detrimental impact on the size or health of the initial follicle endowment, leading to accelerated follicle loss over time.

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Section: Discussionsupporting

confidence: 54%

Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?

Bleil

English

Valle

et al. 2018

womens midlife health

View full text Add to dashboard Cite

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“…Studies investigating the ovaries of female offspring (F1 generation) of smoking mothers showed significantly increased OS levels in oocytes, further leading to apoptosis and the abnormal proliferation of granulosa cells [ 105 ]. This effect continued into the F2 generation with impact on ovarian function not declining until the F3 generation [ 106 ].…”

Section: Factors Related To Os That Lead To Ovarian Agingmentioning

confidence: 99%

The role of oxidative stress in ovarian aging: a review

et al. 2022

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Ovarian aging refers to the process by which ovarian function declines until eventual failure. The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is considered to be a key factor. This review focuses on the fact that OS status accelerates the ovarian aging process by promoting apoptosis, inflammation, mitochondrial damage, telomere shortening and biomacromolecular damage. Current evidence suggests that aging, smoking, high-sugar diets, pressure, superovulation, chemotherapeutic agents and industrial pollutants can be factors that accelerate ovarian aging by exacerbating OS status. In addition, we review the role of nuclear factor E2-related factor 2 (Nrf2), Sirtuin (Sirt), mitogen-activated protein kinase (MAPK), protein kinase B (AKT), Forkhead box O (FoxO) and Klotho signaling pathways during the process of ovarian aging. We also explore the role of antioxidant therapies such as melatonin, vitamins, stem cell therapies, antioxidant monomers and Traditional Chinese Medicine (TCM), and investigate the roles of these supplements with respect to the reduction of OS and the improvement of ovarian function. This review provides a rationale for antioxidant therapy to improve ovarian aging.

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“…[17][18][19][20] In females, prenatal exposure to air pollution has been shown to induce a dramatic decrease in the size of the gonads due to alterations in germ cell development, gametogenesis and folliculogenesis that negatively affects the ovarian follicular reserve in offspring. [21][22][23][24][25][26][27] All these studies were done in rodents, mainly by exposure of the entire animals during gestation, and in some cases during lactation as well. 19,24,25 Questions remain which are difficult to answer: was the mother contaminated by ingestion (leaking) of pollutants or by inhalation?…”

Section: Introductionmentioning

confidence: 99%

“…[21][22][23][24][25][26][27] All these studies were done in rodents, mainly by exposure of the entire animals during gestation, and in some cases during lactation as well. 19,24,25 Questions remain which are difficult to answer: was the mother contaminated by ingestion (leaking) of pollutants or by inhalation? By which mechanism (acting on germ cell mitosis, or meiosis; or acting on somatic cells differentiation) does pollution affect the gonad?…”

Section: Introductionmentioning

confidence: 99%

Impact of a gestational exposure to diesel exhaust on offspring gonadal development: experimental study in the rabbit

Torres-Rovira

Monniaux

Faure

et al. 2018

J Dev Orig Health Dis

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The aim of the present work was to address experimentally the possible impact of exposure to air pollution during gestation on the differentiation and function of the gonads of the offspring using a rabbit model. Rabbits were exposed daily to diluted diesel exhaust gas or filtered air from the 3rd until the 27th day of gestation, during which time germ cells migrate in genital ridges and divide, and fetal sex is determined. Offspring gonads were collected shortly before birth (28th day of gestation) or after puberty (7.5 months after birth). The structure of the gonads was analyzed by histological and immunohistological methods. Serum concentrations of testosterone and anti-Müllerian hormone were determined using ELISA. The morphology and the endocrine function of the gonads collected just at the arrest of the exposure were similar in polluted and control animals in both sexes. No differences were observed as well in gonads collected after puberty. Sperm was collected at the head of the epididymis in adults. Sperm motility and DNA fragmentation were measured. Among all parameters analyzed, only the sperm DNA fragmentation rate was increased three-fold in exposed males. Mechanisms responsible for these modifications and their physiological consequences are to be further clarified.

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Grandmaternal smoke exposure reduces female fertility in a murine model, with great-grandmaternal smoke exposure unlikely to have an effect

Cited by 10 publications

References 43 publications

Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?

Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?

The role of oxidative stress in ovarian aging: a review

Impact of a gestational exposure to diesel exhaust on offspring gonadal development: experimental study in the rabbit

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