Grand-mal as the major presenting symptom of infectious mononucleosis.

Mozes, Benjamin; Pines, A.; Werner, Dudley; Kaplinsky, N; Frankl, O

doi:10.1136/jnnp.47.5.569

Cited by 7 publications

(1 citation statement)

References 10 publications

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“…In a large Polish registry including 194 children diagnosed with EBV infection with positive serology, febrile seizures occurred in 3.1% of cases younger than 5 years ( 26 ). Seizures during the course of EBV neuroinfection have been described as generalized tonic-clonic ( 27 ), focal ( 28 ), convulsive ( 29 ), and nonconvulsive ( 30 ) status epilepticus, and myoclonic seizures ( 31 ). Expression of IL-6 and IL-1β was shown to be strongly enhanced in interfollicular areas of tonsils of children with infectious mononucleosis ( 32 ), suggesting that EBV infection results in the expression of specific cytokine genes in EBV-infected and neighboring cells, but little is known on the proinflammatory cytokine profiles in cases of neurological manifestation of EBV infection.…”

Section: Introductionmentioning

confidence: 99%

Detection of HHV-6 and EBV and Cytokine Levels in Saliva From Children With Seizures: Results of a Multi-Center Cross-Sectional Study

et al. 2018

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Background and Objective: One third of children with epilepsy are refractory to medications. Growing data support a role of common childhood infections with neurotropic viruses and inflammation in epileptogenesis. Our objective was to determine the frequency of Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) infection and cytokine levels in saliva from children with seizures compared to healthy controls and to controls with a febrile illness without seizures.Methods: In this cross-sectional multi-center study, we collected saliva from 115 consecutive children with acute seizures (cases), 51 children with a fever and no seizures or underlying neurological disease (fever controls) and 46 healthy children (healthy controls). Specimens were analyzed by a novel droplet digital PCR for HHV-6 and EBV viral DNA and a bead-based immunoassay for neuroinflammatory cytokines.Results: Cases included febrile seizures (n = 30), acute seizures without (n = 53) and with fever (n = 4) in chronic epilepsy, new onset epilepsy (n = 13), febrile status epilepticus (n = 3), and first lifetime seizure (n = 12). HHV-6 DNA was found in 40% of cases vs. 37% fever controls and 35% healthy controls, with no statistically significant differences. EBV DNA was also detected with no differences in 17% cases, 16% fever controls, and 28% healthy controls. IL-8 and IL-1β were increased in saliva of 32 random samples from cases compared with 30 fever controls: IL-8 cases mean (SD): 1158.07 pg/mL (1427.41); controls 604.92 (754.04); p = 0.02. IL-1β 185.76 (230.57); controls 86.99 (187.39); p = 0.0002. IL-1β level correlated with HHV6 viral load (p = 0.007).Conclusion: Increase in inflammatory cytokines may play a role in the onset of acute seizures and saliva could represent an inexpensive and non-invasive method for detection of viral DNA and cytokines.

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