Gram-Scale Synthesis of Substituted Triarylmethanes

Abstract

A high-yield, open-vessel route for the facile-operational, gram-scale synthesis of functionalized triarylmethanes (TRAMs) is described­ via silica-coated magnetic nanoparticles of modified polyphosphoric­ acid (NiFe2O4@SiO2-PPA)-mediated intermolecular Friedel­–Crafts reaction of substituted aryl aldehydes with 2 equivalents of oxygenated arenes under environmentally friendly reaction conditions. Among the overall reaction process, only water was generated as the by-product. Various reaction conditions are investigated for efficient transformation.