Gram-scale synthesis of boron nitride nanosheets by salt-template method for anticancer drug delivery

Cheng, Yuanmeng; Han, Yuxin; Zhang, Wei; Zeng, Lula; Long, Yanyang; Wang, Shuying; Weng, Qunhong

doi:10.1016/j.cej.2022.135304

Cited by 24 publications

(12 citation statements)

References 48 publications

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“…34 However, CPT is only slightly soluble in water and aqueous solutions, has poor stability under physiological conditions, fast plasma clearance and high systemic toxicity, and thus are greatly limited in clinical applications. 18 Thus, development of a suitable carrier to overcome the water solubility and stability of CPT is very meaningful in clinic. Here, we propose to employ the designed TPEA-BQ COFNPs as the delivery system of CPT for anticancer treatment.…”

Section: Resultsmentioning

confidence: 99%

“…For this topic, numerous inorganic nanocarriers have been reported to show high efficiency in drug delivery, including porous silicon, 11,12 quantum dots, 13,14 gold, 15 BN nanosheets, 16–18 etc. However, these materials are difficult to degrade at physiological conditions and may cause long-term toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] Thus, development of drug delivery carriers to improve drug targeted transportations and circulation stabilities is vital to reduce the side effects of chemotherapy. 10 For this topic, numerous inorganic nanocarriers have been reported to show high efficiency in drug delivery, including porous silicon, 11,12 quantum dots, 13,14 gold, 15 BN nanosheets, [16][17][18] etc. However, these materials are difficult to degrade at physiological conditions and may cause long-term toxicity.…”

Section: Introductionmentioning

confidence: 99%

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Design of size uniform and controllable covalent organic framework nanoparticles for high-performance anticancer drug delivery

et al. 2022

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Covalent organic frameworks (COFs) receive much attention in biomedicine because of their unique adsorption, optical and biological properties, as well as highly variable structures. However, preparation of nanosized COFs with uniform and controllable size is still a challenge. Herein, we develop a facile interfacial method to prepare the COF nanoparticles (COFNPs) with the uniform size of 30–50 nm from p-benzoquinone (BQ) and 4-[1,2,2-tris(4-aminophenyl)ethenyl]aniline (TPEA) by Michael addition. The TPEA-BQ COFNPs show positive zeta potential and effectively load the hydrophobic anticancer drug camptothecin (CPT) with the capacity of up to 127wt%, and remarkably improved the CPT dispersibility in water due to the retention of quinone structure. In vitro assay reveals CPT@ TPEA-BQ significantly reduced cell viability to 29% after 24 h incubation, much lower than that of free CPT (51%) at the same concentration of 10 μg mL−1. Further in vivo experiment confirms the high anticancer drug delivery performance of the designed TPEA-BQ COFNPs. After 20 days of injection treatment, the CPT loaded in TPEA-BQ COFNPs inhibits the tumor growth by 60%, much higher than that of free CPT group (23%). This work demonstrates the feasibility to design advanced drug delivery systems based on highly structure-tunable COF system.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design of size uniform and controllable covalent organic framework nanoparticles for high-performance anticancer drug delivery

et al. 2022

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“…Chemotherapy, as a mainstream treatment option, is effective in killing cancer cells directly. However, it is associated with challenges including low bioavailability, significant side effects, and drug resistance. , In the case of breast cancer, camptothecin (CPT), a natural alkaloid derived from the camphor tree, demonstrates potent antibreast cancer activity by inhibiting topoisomerase I (TOPO-I). , Despite these promising characteristics, CPT has poor water solubility (∼1.2 μg/mL), limited therapeutic efficacy, and serious side effects, hindering its clinical applications. , Therefore, the development of a tailored nanocarrier is essential to address the challenges associated with CPT . In this regard, several nanocarriers have been designed to mitigate side effects and enhance the therapeutic potency of CPT in the body. − …”

Section: Introductionmentioning

confidence: 99%

Red-Fluorescent Covalent Organic Framework Nanospheres for Trackable Anticancer Drug Delivery

Zhang,

Xiang,

Long

et al. 2023

ACS Appl. Mater. Interfaces

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Covalent organic frameworks (COFs) have emerged as promising drug carriers due to their structural variability, inherent porosity, and customizable functions. However, most COFs used in drug delivery suffer from low cellular bioavailability and poor luminescence properties. In this study, we designed a series of size-tunable, crystalline, and redfluorescent COF nanospheres (COFNSs) for trackable anticancer drug delivery. The semiconducting COFNSs were prepared by condensations of 1,3,5-triformylbenzene (TFB) with various dihydrazide blocks through the Schiff-base reaction, resulting in red emission at 647 nm and excellent fluorescence stability (∼100% for 1 h). Such fluorescence property allowed for systematic investigation of the cellular endocytosis pathway of COFNSs, visualization of drug delivery, and observation of the cell apoptosis process. The COFNSs exhibited high cell viability (>90%), a loading capacity of 183 wt % for the anticancer drug camptothecin (CPT), and significant enhancement in inhibiting 4T1 cancers both in vitro and in vivo as the CPT nanocarrier. This progress presents a valuable approach to design COF nanocarriers with integrated fluorescent and drug delivery functions.

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“…Nevertheless, the related research in cancer therapy is still at an early stage. 31,32 Metal-organic framework materials (MOFs) are coordination polymers formed by metal ions and organic ligands, known for their three-dimensional intrinsically porous structure. 33,34 Zeolite imidazolium framework (ZIF), a type of MOF, exhibits excellent thermal and chemical stability, making it suitable for drug delivery and various biomedical applications.…”

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confidence: 99%

Flower-like porous BCN assembled by nanosheets for paclitaxel delivery

Wang,

Deng

et al. 2023

Chem. Commun.

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Gram-scale synthesis of boron nitride nanosheets by salt-template method for anticancer drug delivery

Cited by 24 publications

References 48 publications

Design of size uniform and controllable covalent organic framework nanoparticles for high-performance anticancer drug delivery

Design of size uniform and controllable covalent organic framework nanoparticles for high-performance anticancer drug delivery

Red-Fluorescent Covalent Organic Framework Nanospheres for Trackable Anticancer Drug Delivery

Flower-like porous BCN assembled by nanosheets for paclitaxel delivery

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