Gram-scale purification of dehydroevodiamine from Evodia rutaecarpa fruits, and a procedure for selective removal of quaternary indoloquinazoline alkaloids from Evodia extracts

Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study

“…Evodiae fructus , an eminent Chinese herbal medicine, demonstrated its therapeutic capabilities in regard to anti-analgesic antiemetic and anti-inflammatory effects in gastrointestinal and cardiovascular diseases [ 90 , 91 ]. Alkaloids, including evodiamine and rutaecarpine, are the major bioactive ingredient in Evodiae fructus , and were reported to alleviate colorectal carcinoma, atherosclerosis and cardiovascular relaxation [ 92 , 93 ].…”

Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder

“…Dehydroevodiamine, evodiamine and rutaecarpine are the dominant bioactive constituents in Fructus evodiae [50]. The extract of Fructus evodiae could be used as a potential remedy for hangover symptoms induced by alcohol on mice by stimulating the expression of hepatic alcohol metabolizing and antioxidant enzymes [51].…”

“…Mice Suppression of alcohol-induced liver steatosis by modulating the disturbance of the peroxisome proliferator-activated receptor α pathway and ameliorating mitochondrial function [42] Cells Suppression of alcohol-induced apoptosis in human neuroblastoma cells [43] Puerarin and daidzein Root Humans Reduced alcohol intake in a naturalistic setting [45] Humans Reduced alcohol consumption in a binge drinking paradigm [46] Rats Reduced anxiogenic effects of alcohol withdrawal via increased social interaction and locomotor activity [47] Rats Mitigation of liver damage (AST, ALT, GGT) and lipid deposition induced by chronic alcohol intake as well as TNF-α release, protein expression of endotoxin receptors [48] Fructus evodiae Dehydroevodiamine, evodiamine and rutaecarpine Dried and unripe fruit Mice Alleviation of hangover through stimulating the expression of hepatic alcohol metabolizing and antioxidant enzymes [50] Rats Prevention of alcohol-induced gastric mucosal lesions by strengthening the mucosal barrier integrity and increasing gastric mucosal nitric oxide (NO) synthesis [51] Trigonela foenum-graecum Polyphenols Seeds Cells Prevention of the toxic effects of alcohol through increased cell viability, reduced lactate dehydrogenase leakage and normalized GSH/GSSG ratios [53,55] Rats Suppressed alcohol-induced abnormalities in the liver through restoration of liver enzymes, ADH and ALDH activities [54] Rats Suppression of alcohol toxicity through prevention of enzymatic leakage, and improved lipid profiles [56][57][58] …”

Gram-Scale Purification of Dihydrorobinetin from Robinia pseudoacacia L. Wood by Centrifugal Partition Chromatography

“…Until now, most of the chromatographic methods used to perform gram-scale purifications of natural compounds were based on solid support (i.e., medium performance liquid chromatography [25], flash chromatography [26], preparative liquid chromatography on macroporous resin [27] or on reversed phase column [28], and supercritical fluid chromatography [29]). Interestingly, CPC separations rely on the use of a liquid stationary phase that presents numerous advantages such as (i) no irreversible adsorption of samples; (ii) no compound degradation; (iii) high column loading capacity; (iv) high sample recovery; (v) lower cost; and (vi) shorter separation time [30,31].…”