Gram‐positive bacteria on grass pollen exhibit adjuvant activity inducing inflammatory T cell responses

Heydenreich, Bärbel; Bellinghausen, Iris; König, Bettina; Becker, W.M.; Grabbe, Stephan; Petersen, Arnd; Saloga, Joachim

doi:10.1111/j.1365-2222.2011.03888.x

Cited by 53 publications

(52 citation statements)

References 32 publications

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“…11 This study provides evidence that certain microbes can be characteristically identified in allergic rhinitis. Presence of microbes in pollen was demonstrated in study by Heydenreich et al 12 These microbes in pollen can act as adjuvant and initiate an allergic immune response. The microbes in pollen could possibly explain the change in flora and recurrent infection in allergic rhinitis patients.…”

Section: Discussionmentioning

confidence: 99%

Nasal flora in allergic rhinitis

Rajasekaran

Kumar

Sriraman

2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Allergic rhinitis is a common cause for recurrent rhinosinusitis. The microbiology in allergic nasal mucosa has not been much documented. The aim of the study is to identify the microbes in the middle meatus in patients with allergic rhinitis and to compare with the normal nasal flora. Methods: A cross sectional study was conducted in our institute to study the nasal microbial pattern in 50 patients with allergic rhinitis and was compared with 50 normal healthy nasal flora. Nasal swabs were taken from middle meatus under endoscopic guidance in both the groups and sent for microbial analysis. Results: Organisms like Klebsiella, E.coli, and Staphylococcus aureus were predominant isolates in patients with allergic rhinitis, whereas Staph epidermidis were predominant in controls. Conclusions: This alteration in microbial flora could possibly explain recurrent sinonasal infections in patients with allergic rhinitis.

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Section: Discussionmentioning

confidence: 99%

Nasal flora in allergic rhinitis

Rajasekaran

Kumar

Sriraman

2017

Int J Otorhinolaryngol Head Neck Surg

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“…How can a more biodiverse environment with more flowering plant influence our skin microbiota? One possible mechanism previously described is that pollen grains and particles may serve as vehicles for microbes endowed with an adjuvant effect that may influence immune responses through Toll-like receptor (TLR) activation on dendritic cells (17,18). It is noteworthy that the findings from the Karelia studies have contributed to establishing a successful nationwide Finnish programme for the prevention of allergies (19,20).…”

Section: Environmental Biodiversity Microbiome and Allergy: Immunolomentioning

confidence: 99%

Update in clinical allergy and immunology

Gunten

Marsland

Garnier

et al. 2012

Allergy

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In the recent years, a tremendous body of studies has addressed a broad variety of distinct topics in clinical allergy and immunology. In this update, we discuss selected recent data that provide clinically and pathogenetically relevant insights or identify potential novel targets and strategies for therapy. The role of the microbiome in shaping allergic immune responses and molecular, as well as cellular mechanisms of disease, is discussed separately and in the context of atopic dermatitis, as an allergic model disease. Besides summarizing novel evidence, this update highlights current areas of uncertainties and debates that, as we hope, shall stimulate scientific discussions and research activities in the field.Research progress goes ahead fast, and each issue of Allergy distributes a dozen of new and interesting papers providing actual research results, opinions and reviews in different fields of allergy and clinical immunology. Over time, it becomes difficult to keep an overview on the novelties and trends given by these articles. Here, we give an update aiming to summarize interesting papers published in Allergy over the last years and putting them in context with recently published work in the field. As we were not able to cover all fields, we selected three research subjects: (i) Hygiene hypothesis: the role of the microbiome in allergy; (ii) Pathogenic mechanisms of allergic diseases and their potential therapeutic implications; (iii) Atopic dermatitis (AD): skin barrier and allergic inflammation. In our view, the selected papers provide new insights in clinically and pathogenetically important research as well as novel targets and strategies for therapy that might become starting points for future research.

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“…Pantoea agglomerans is from Enterobacteriaceae family. It possess adjuvant activity by greatly enhancing dendritic cells maturation and induction of Th1-, Th2-and Th17-mediated allergic infl ammation (Heydenreich et al, 2011). Penicillium and Alternaria are known anemophilous pollen concomitants Hani et al, 2012;Kačániová et al, 2014;Śpiewak et al, 1996;Dziadzio, 2001;Rodríguez-Carrasco et al, 2013).…”

Section: Ii: Microbial Enumeration Of Betula Trees Samples Collected mentioning

confidence: 99%

“…Gram-negative and Gram-positive bacteria, as well as endotoxin, mould were revealed on the surface of the pollen grains of anemophilous plants (Śpiewak et al, 1996a;Heydenreich et al, 2011;Mittag et al, 2013). Mould is the source of allergens in itself (Heydenreich et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microbial Diversity of Betula Trees: Pollen, Catkins, Leaves Relatively of Flowering

Shevtsova

Petrová

Brindza

et al. 2016

Acta Univ. Agric. Silvic. Mendelianae Brun.

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Quantitative microbiological analysis by dilution plating method of pollen and additional male and female catkins, leaves of Betula verrucosa Ehrh. and its two cultivars: 'Purpurea' and 'Youngii' relatively of fl owering period of Betula has been realized with the aim to provide new knowledge of the microbiological quality of anemophilous pollen for processing and its further application. Qualitative microbiological analysis with MALDI-TOF MS Biotyper was used in the identifi cation of aerobic, anaerobic mesophilic bacteria and coliforms. Mixed microbiota was determined, consisting of aerobic (4.68-4.89 log cfu/g) and anaerobic (3.30-3.48 log cfu/g) mesophilic bacteria, lactobacilli (0-3.48 log cfu/g), coliform bacteria (0-4.57 log cfu/g), fungi and yeast (3.78-3.95 log cfu/g) on the pollen grains, that indicates acceptable quality in comparison with the microbiological quality parameters for bee pollen. Pantoea agglomerans was found associated with pollen of Betula verrucosa Ehrh. Recommendations on the collection of anemophilous pollen were established.

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Gram‐positive bacteria on grass pollen exhibit adjuvant activity inducing inflammatory T cell responses

Cited by 53 publications

References 32 publications

Nasal flora in allergic rhinitis

Nasal flora in allergic rhinitis

Update in clinical allergy and immunology

Microbial Diversity of Betula Trees: Pollen, Catkins, Leaves Relatively of Flowering

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