Gram‐Positive Antimicrobial Activity of Amino Acid‐Based Hydrogels

Irwansyah, I.; Li, Yongqiang; Shi, Wenxiong; Qi, Dianpeng; Leow, Wan Ru; Tang, Mark Boon Yang; Li, Shuzhou; Chen, Xiao

doi:10.1002/adma.201403339

Cited by 192 publications

(156 citation statements)

References 70 publications

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“…19,22,23 Furthermore, most of gel phase applications are based on twocomponent gels. 19 Under this light, two-component gels formed by mixtures of amino acid derivatives, 24 carboxylic acids and amines, 25,26 chiral perylenebisimide derivatives and 4,4'-bipyridyl units, 23 dendritic moieties, [27][28][29] surfactant molecules and bola-amphiphilic additives, 30 naphthalenediimide derivatives and dihydroxynaphthalenes, 31 and so on have been reported. Active molecules and additives have to be dissolved within the gel matrix and released when required.…”

Section: Introductionmentioning

confidence: 94%

Organic salts and aromatic substrates in two-component gel phase formation: the study of properties and release processes

et al. 2015

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To identify gel phases able to act as confined reaction media or materials for the removal of organic pollutants, we studied two-component gel phases formed by naphthalenedisulfonate diimidazolium salts in the presence of some organic guests, in 1-propanol solution. Guests differing in π-surface area, bulkiness and electronic properties were taken into account. Soft materials obtained were investigated for their thermal stability, self-repairing ability and morphology. Furthermore, two-component gel phase formation was studied using resonance light scattering (RLS) measurements. Guest release processes from the gel phase were also studied. These processes were monitored as a function of time using both UV-vis and RLS measurements and considering important parameters such as the gelator concentration, the nature of extraction solvent and the extension of contact surface area between solvent and gel phase. Data collected shed light on the properties of the two-component gels and could represent a useful tool to better plan the application of these soft materials.

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Section: Introductionmentioning

confidence: 94%

Organic salts and aromatic substrates in two-component gel phase formation: the study of properties and release processes

et al. 2015

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“…[50] The hydrogels exhibited selective activity against gram-positive bacteria by disrupting the cell wall and membrane. The hydrogels were also found to be biocompatible with mammalian cells.…”

Section: Amino Acid Based Nanostructuresmentioning

confidence: 99%

Amino Acid Based Self‐assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks

Chakraborty

Gazit

2018

ChemNanoMat

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Amino acids are the simplest biological building blocks capable of forming discreet nanostructures by supramolecular self-assembly. The understanding of the process of organization of amino acid nanostructures is of fundamental importance for the study of metabolic diseases as well as for materials science applications. Although peptide self-assembled structures have been the topic of many review articles, much less attention has been devoted to the ability of amino acid building blocks, both natural and synthetic, to form ordered assemblies with defined architectures and notable physical properties, by the process of self-association. Herein, we try to shed light on amino acid based nanostructures, their fabrication and implications. We discuss self-assembled nanostructures, including hydrogels with nanoscale order, obtained from both modified and unmodified single amino acids. We also envision some future prospects in this emerging field.

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“…[1][2][3][4][5][6] Current detection techniques have polymerase chain reaction (PCR), 7 biomedical staining 8,9 and standard plate count (SPC), 10 but these methods are complicated and expensive. Thus, the development of methods for detection and treatment of bacteria has become a popular research.…”

Section: Introductionmentioning

confidence: 99%

A purpurin-peptide derivative for selective killing of Gram-positive bacteria via insertion into cell membrane

Zhou

Wang

2016

J. Mater. Chem. B

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Pathogenic bacteria can cause significant morbidity and it becomes a critical public healthcare problem. To date, effective identification and killing of bacteria remains a major challenge in bacterial infection. Although numerous materials have been designed for bacteria identification, few materials can discriminate different bacteria effectively. In this work, we designed a new polyarginine chlorophyll derivative (PA7), which can identify different bacteria successfully. PA7 was composed of a cationic hydrophilic chain and a hydrophobic purpurin-18 core and had variable binding capability towards different bacteria based on their surface component and structure. We observed that PA7 molecule preferrentially bound to Gram-positive bacteria (i.e., S. aureus) than to Gram-negative one (i.e., E. coli) through CLSM image. Furthermore, ζ potential experimental results indicated that the binding ability of PA7 to Gram-negative (E. coli) was more susceptible to the ionic strengths. Given the fact that the two kinds of bacteria possess different cell envelope components, we speculated that the binding of PA7 to S. aureus was dominated by electrostatic and hydrophobic interactions, and only electrostatic interaction for E.coli. Moreover, the PA7 could be used as a good photoacoustic contrast agent. PA7 could discriminate Gram-positive bacteria and Gram-negative bacteria via photoacoustic imaging in the buffer solution with variable ionic strengths. Effective killing of bacteria was another motivation of the molecular design. PA7 as a potential photosensitizer exhibited much higher photodynamic antibacterial activity to S. aureus. BriefsA purpurin-peptide derivative was used for discriminating and killing bacteria based on the different surface component of bacteria.

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Gram‐Positive Antimicrobial Activity of Amino Acid‐Based Hydrogels

Cited by 192 publications

References 70 publications

Organic salts and aromatic substrates in two-component gel phase formation: the study of properties and release processes

Organic salts and aromatic substrates in two-component gel phase formation: the study of properties and release processes

Amino Acid Based Self‐assembled Nanostructures: Complex Structures from Remarkably Simple Building Blocks

A purpurin-peptide derivative for selective killing of Gram-positive bacteria via insertion into cell membrane

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