Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs

Paitan, Yossi; Ron, Eliora Z.

doi:10.1007/978-3-642-39968-8_3

Cited by 1 publication

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“…The study of the molecular mechanisms of antifouling activity from Pseudoalteromonas species is promising for multiple applications, such as biofouling control in aquaculture and novel drug discovery. In particular, the isolation of novel antibiotics is strategically important, considering the global threat for human's health posed by the emergence of multi-drug resistant (MDR) pathogens, mainly due to antibiotic over usage (Paitan & Ron, 2014). Finally, the most studied Pseudoalteromonas strain, namely Pseudoalteromonas haloplanktis TAC125 (Médigue et al, 2005), has been suggested as an alternative host for the soluble overproduction of heterologous proteins, given its ability to grow fast at low temperatures (Wilmes et al, 2010;Rippa et al, 2012;Corchero et al, 2013;Giuliani et al, 2014).…”

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confidence: 99%

Genome-scale phylogenetic and DNA composition analyses of Antarctic Pseudoalteromonas bacteria reveal inconsistencies in current taxonomic affiliation

et al. 2015

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Abstract:Bacteria belonging to the Pseudoalteromonas genus have important ecological implications in marine environments, playing a role in the control of microbial community as producers of bioactive molecules endowed with antifouling activity and able to antagonize larvae, fungi and bacteria, including important human pathogens. For these reasons, representatives of this genus are very promising from an applicative viewpoint. Despite representing a very important point with drawbacks in strains selection, classification and exploitation, the taxonomic history of this genus dates back to 1995 when Gautier defined the genus relying on a single gene (16S rRNA) analysis. In this work we used different genome-scale approaches to evaluate the taxonomy of 38 Pseudoalteromonas representatives (most of which isolated from Antarctica) and whose complete genome has been sequenced. We show that an accurate reevaluation of the real taxonomic relationships of Pseudoalteromonas representatives is needed since many inconsistencies with the current taxonomic annotation were observed. Moreover, data obtained with different genome-scale methods are consistent, confirming the reliability of the genomic approaches. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems CorporationOn the basis of these data we propose a re-annotation for some Pseudoalteromonas species. This proposal will be validated in the future by comparing the phenotypes of these strains. Response to Reviewers:Powered Abstract Bacteria belonging to the Pseudoalteromonas genus have important ecological implications 28 in marine environments, playing a role in the control of microbial community as producers of bioactive 29 molecules endowed with antifouling activity and able to antagonize larvae, fungi and bacteria, 30 including important human pathogens. For these reasons, representatives of this genus are very 31 promising for biotechnological and biomedical applications. 32In this work we used different genome-scale approaches to infer the taxonomy of 38 33Pseudoalteromonas representatives (most of which isolated from Antarctica) and whose complete 34 genome has been sequenced. We show that an accurate re-evaluation of the real taxonomic 35 relationships of Pseudoalteromonas representatives is needed since many inconsistencies with the 36 current taxonomic annotation were observed. Moreover, data obtained with different genome-scale 37 methods are consistent, confirming the reliability of the genomic approaches. 38On the basis of these data we propose a re-annotation for some Pseudoalteromonas species. 39 3 This proposal should be validated in the future by comparing the phenotypes of these strains. 40 41

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