The influence of fluctuations in the grain size along the gage length on ductility is analyzed in the superplastic regime. It is demonstrated that these fluctuations produce a similar effect to that produced by variations in the initial uniformity of the sample, leading to premature necking. In order to reach superplastic elongations of 400%, fluctuations in grain size of less than 0.5% between two zones of the gage length are required. As an example, the superplastic behavior of an AZ61 alloy, processed by severe plastic deformation, SPD, with a heterogeneous microstructure, is analyzed when the grain boundary sliding mechanism controls deformation. It is found that neck formation is related to bands of fine grains that are formed during SPD processing due to the mechanism of recrystallization by rotation. Under these circumstances grain refinement is rendered unsuccessful. The present investigation emphasizes the importance of the microstructure homogeneity in developing grain refinement processing routes.