Grafting of ω-Functionalized PVP Oligomers onto Dextran: A Novel Route to Biodegradable and Biocompatible Polymers

Self-assembled polypeptide-block-poly(vinylpyrrolidone) as prospective drug-delivery systems

“…Considerable efforts have been devoted to the design of new functionalized PVP oligomers and as intermediates in the synthesis of complex macromolecular architectures, such as graft-copolymers [15], micelles [16], and liposomes [17]. End-functionalized PVP oligomers can be used as hydrophilic macroinitiators in the ring opening polymerization (ROP) of cyclic monomers such as lactones or lactides in order to prepare diblock copolymers, as they possess some unique properties [18,19].…”

Synthesis of Novel Monomers and Copolymers from 1‐Vinylpyrrolidin‐2‐one: Attractive Materials for Drug Delivery Systems?

“…PVP itself can also be grafted onto other polymer backbones. [3,4] Graft copolymers can be prepared either by growing polymer chains from a polymer backbone, or by attaching an existing polymer chain onto the backbone. An example of grafting side chains onto a PVPbackbone is the Ganex 1 series which is produced by reacting a formed radical on the pyrrolidone ring with a-olefins in various amounts and chain lengths.…”

Hydrogels from Chitosan and a Novel Copolymer Poly(<i>N</i>-Vinyl-2-Pyrrolidone-<i>Co</i>-Acrolein)

“…It must be emphasized here that there are already numerous natural and synthetic polymers being studied and/or applied as medicinal hydrogels, and PVP is among them [24,25]. But, beyond PVP as a unique polymer, other polymer systems involving VP-monomers are also used in this application area: chemically modified PVP [26][27][28], copolymers containing units of N-vinyl-2-pyrrolidone in their chains for example, poly(methacrylamide-co-N-vinyl-2-pyrro-lidone-co-itaconic acid) [29]; poly(N-vinyl-2-pyrrolidone-co-styrene) [30]; poly(N-vinyl-2-pyrrolidone-coacrylic acid), [31] and blends of PVP with other biocompatible polymers (for example, PVP-CMC [32]; PVP-PVA [33]; PVP-k-carrageenan [34]; PVP-chitosan [35].…”