Graft-vs-Host Reaction

Grogan, Thomas M.

doi:10.1001/archderm.1977.01640060102014

Cited by 36 publications

(11 citation statements)

References 22 publications

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“…Histology of the macular erythema showed epidermal cell degeneration asso ciated with lymphocytic infiltration of the epidermis and 'satellitosis'. These findings were consistent with, but not specific for, grade 1 acute cutaneous GvHD [15,16].…”

Section: Histological Findingssupporting

confidence: 82%

“…The rash most often started on the head, neck, trunk or upper extremities, and frequently progressed to involve the entire body. The skin biopsy was often helpful in suggesting the diag nosis but was rarely pathognomonic [15,16]. Basal layer degeneration, eosinophilic cell necrosis and satellitosis are highly suggestive of GvHD in the proper clinical setting.…”

Section: Discussionmentioning

confidence: 99%

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Acute Graft-versus-Host Disease Resulting from Normal Donor Blood Transfusions

et al. 1984

Acta Haematol

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2 fatal cases of graft-versus-host disease (GvHD) occurred following blood product transfusions given to patients receiving standard chemotherapy for Hodgkin’s disease. GvHD was established by HLA typing, clinical course, and compatible skin biopsy. 23 cases of GvHD following transfusion of blood products from normal donors are also reviewed. It should be suspected when fever or rash appear 1–2 weeks after transfusion of unirradiated blood products into a compromised host or when pancytopenia following chemotherapy is prolonged or unexpectedly severe. Prevention of GvHD by irradiation of granulocytes, platelets and packed red blood cells given to immunosuppressed patients is recommended to prevent this often fatal disease

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Section: Histological Findingssupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Acute Graft-versus-Host Disease Resulting from Normal Donor Blood Transfusions

et al. 1984

Acta Haematol

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“…These cells, incompletely matched with the histocompatibility antigens of the recipient, could contribute unacceptably to graftversus-host disease (GVHD). GVHD which had occurred in children with severe combined immunodeficiency (SCID) who had not undergone transplantation was the first evidence of the presence of maternal cells in neonatal blood (Grogan et al, 1985). Subsequently, maternal cells were detected by HLA-typing in children suffering from SCID without any GVHD (Pollack et al, 1982).…”

Section: ¹4mentioning

confidence: 99%

Detection of maternal cells in human fetal blood during the third trimester of pregnancy using allele‐specific PCR amplification

et al. 1997

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Summary. Using a highly sensitive allele-specific PCR amplification method, we have previously shown that maternal cells could be detected in all 10 cord bloods tested. This raised the question of whether maternal cells are released into cord blood during the process of delivery or whether they are already present during pregnancy. We have now used the same PCR method to detect the presence of maternal cells in nine fetal blood samples collected at different gestational ages. Maternal cells were detected in eight samples obtained between 24 and 35 weeks of gestation. They were estimated to amount between 10 ¹4and 10 ¹5 of nucleated fetal blood cells. In two cases mononuclear and polymorphonuclear cell fractions were separated by Ficoll gradient centrifugation and maternal cells were detected as comparable levels in both fractions. Maternal cells could not be detected in the one fetal blood sample obtained at 20 weeks of gestation, suggesting that maternal cells could appear at detectable levels in fetal blood during the third trimester of pregnancy. These results are discussed in terms of materno-fetal immune tolerance and of transmission of viruses (and more specifically of the human immunodeficiency virus) from mother to child.

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“…Human GVHD is most commonly seen following allogeneic bone marrow transplantation (BMT), although it has also been reported following transfusion of nonirradiated blood products into immunodeficient subjects,1,2 and after maternofetal cell transfer in immunodeficient children. 3 The predominent target organs for GVHD are skin, liver, and the gastrointestinal tract. In acute GVHD, skin involvement is frequent and is often the initial site of involvement.…”

mentioning

confidence: 99%

Acute follicular graft-vs-host reaction. A distinct clinicopathologic presentation

Friedman¹

1988

Archives of Dermatology

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Graft-vs-Host Reaction

Cited by 36 publications

References 22 publications

Acute Graft-versus-Host Disease Resulting from Normal Donor Blood Transfusions

Acute Graft-versus-Host Disease Resulting from Normal Donor Blood Transfusions

Detection of maternal cells in human fetal blood during the third trimester of pregnancy using allele‐specific PCR amplification

Acute follicular graft-vs-host reaction. A distinct clinicopathologic presentation

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